Heat and mass transfer in ternary nanofluid flows over diverse geometries is particularly significant for thermal management in electronic devices, precipitation, and filtration. Chemical reactions are vital processes that occur in a variety of natural and industrial systems. With this initiation, this research explores the impacts of chemical reaction and heat source/sink over MHD ternary nano fluid flow. In addition to this model, we assessed joule heating, viscous dissipation, and activation energy for the study. The ODEs are obtained by using appropriate similarities and the altered non-linear governing equations are solved numerically utilizing RKF-45 and shooting technique. The influence of vital variables on common profiles (flow velocity, thermal gradient, and mass transmission rate) is explored and deliberated graphically in three distinct scenarios. When compared to the other scenarios, the mass transfer for the case of fluid flow across a plate lowers as the activation energy parameter goes up.