Investigation on the interaction of Rutin with serum albumins: Insights from spectroscopic and molecular docking techniques

Sengupta, P.; Sardar, Pinki Saha; Roy, Pritam; Dasgupta, Swagata; Bose, Arup

doi:10.1016/j.jphotobiol.2018.04.019

Cited by 82 publications

(32 citation statements)

References 42 publications

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“…According to the literature, rutin binds to serum albumin but with a lower affinity than simpler polyphenols [ 43 , 44 , 45 , 46 ]. Since less protein binding of the drug means a freer fraction and more volume of distribution, the increase observed in Vdss and Vdz of rutin may be due to the saturation of blood plasma proteins or to displacement of rutin by other components of the extract with higher affinity.…”

Section: Resultsmentioning

confidence: 99%

Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling

et al. 2021

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Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of Physalis peruviana L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study the matrix effects of the extract from P. peruviana calyces on the pharmacokinetics of rutin and its metabolites in Wistar rats, using non-compartmental and population pharmacokinetic analyses. A pharmacokinetic study was performed after intravenous and oral administration of different doses of pure rutin and the extract. In the non-compartmental analysis, it was found that rutin from the extract exhibited higher distribution and clearance, as well as an 11-fold increase in the bioavailability of its active metabolites. A population pharmacokinetic model was also carried out with two compartments, double absorption and linear elimination, in which the extract and the doses were the covariates involved. This model correctly described the differences observed between rutin as a pure compound and rutin from the extract, including the dose dependency.

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Section: Resultsmentioning

confidence: 99%

Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling

et al. 2021

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“…Hence, any study on the binding of plasma protein to compounds can provide useful data on the chemical structure that is attributed to the biological effect of compounds. In addition, there are several studies that have described the interaction of HSA to some phenolic compounds [ [6] , [7] , [8] ]. Therefore, it is very importance to investigation the binding of HSA to phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

Protein binding of 4-hydroxybenzoic acid and 4-hydroxy-3-methoxybenzoic acid to human serum albumin and their anti-proliferation on doxorubicin-sensitive and doxorubicin-resistant leukemia cells

et al. 2021

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“…PCs can be divided into several classes such as phenolic acids, coumarin, stilbenes, tannins, lignans, lignins, flavonoids, etc., depending on their basic chemical structures [3–5] . Generally, PCs are known to possess a high spectrum of biological activities including anti‐cancer, anti‐allergic, anti‐tumor, anti‐inflammatory, anti‐viral, anti‐microbial, anti‐oxidant, cardioprotective effects, and sometimes protect against neurodegenerative diseases, osteoporosis, diabetes, etc [6–10] . Due to such a variety of functional properties, PCs are extensively used in pharmaceutical industries and also utilized as significant food additives and functional compounds in food industries [11,12] .…”

Section: Introductionmentioning

confidence: 99%

Liposomal Encapsulation of Phenolic Compounds for Augmentation of Bio‐Efficacy: A Review

2021

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Naturally occurring phenolic compounds (PCs) exhibit potential biological efficiencies and have potential applications in the food and pharmaceutical industries. Poor water solubility along with some other factors limits the usage of PCs in different industrial sectors. The bio‐efficacy of PCs is also affected due to their low water solubilities. Suitable encapsulating systems are thus required to maximize the water solubility and hence enhance the efficacies of bioactive PCs. Liposomal encapsulation is a good option as reflected in numerous research works. In this review, we have discussed different conventional methods and modified methods utilized to prepare PC‐loaded liposomes and the ensuing effect of encapsulation on the stability and bio‐efficacies of PCs. The encapsulation efficiencies of different methods have also been discussed. A comparative assessment of different methods applied for liposomal encapsulation of PCs and their effectiveness in enhancing bio‐efficacy is the key feature of this review.

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Investigation on the interaction of Rutin with serum albumins: Insights from spectroscopic and molecular docking techniques

Cited by 82 publications

References 42 publications

Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling

Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling

Protein binding of 4-hydroxybenzoic acid and 4-hydroxy-3-methoxybenzoic acid to human serum albumin and their anti-proliferation on doxorubicin-sensitive and doxorubicin-resistant leukemia cells

Liposomal Encapsulation of Phenolic Compounds for Augmentation of Bio‐Efficacy: A Review

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