Investigation on nano microbial cellulose/honey composite for medical application

Abstract

The overall purpose of this study is to investigate the plausibility of employing honey impregnated nano microbial cellulose (NMC) produced in Hestrin-Schramm media as a novel wound dressing. In the initial stage, three predominant characteristics of thyme, Astragalus, and Ziziphus honey including pH, total soluble solids as well as hydrogen peroxide content were assessed. In the second stage, the zone of inhibition diameters for Escherichia coli (E. coli) and Staphylococcus aureus (S. S.areous) were examined respectively. Meanwhile, ATR-FTIR, XRD, and SEM were applied to study the chemical, physical structures, and surface morphology of NMC pellicle. In addition, Air permeability and wettability of samples were studied. The obtained results revealed that in spite of possessing the lowest amount of hydrogen peroxide, thyme honey had the uppermost antibacterial property. Furthermore, wettability and sinking time of treated NMC with thyme honey were 43% and 49% higher than the untreated NMC respectively and purified dry raw cellulose had 11% higher air permeability than dry raw cellulose in 400 Pa. According to the results, the treated NMC with thyme honey has a high potential to be applied in the medical field as a novel wound dressing.

Recent Advances in Honey-Based Nanoparticles for Wound Dressing: A Review

“… [ 61 ] Cellulose/honey composite Composite sheet The treated layer with three types of honey ( Thyme , Astragalus , and Ziziphus ) can absorb water 120 times faster than purified microbial cellulose. [ 62 ] Honey-loaded egg white/poly (vinyl alcohol)/clay Hydrogel The treated layer can collect exudate from te surface 1.37 times faster, which can accelerate wound healing by maintaining the moisture environment of the wound as well as preventing the penetration of bacteria into the wound. Decreased the swelling and dehydration capabilities by increasing the content of incorporated clay nanoparticles.…”

“…In a recent study, Meftahi et al explored a nano microbial cellulose/honey composite for medical application, i.e., wound healing. At the outset of their research, three key features of Thyme, Astragalus, and Ziziphus honey were evaluated: pH, total soluble solids, and hydrogen peroxide content [ 62 ]. In the second stage, the zone of inhibition diameters of E. coli and S. aureus were measured.…”

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

“…In recent years, different authors have evidenced the efficiency related to the use of BC incorporated with natural components in accelerating the healing process when compared to treatment with traditional dressings, especially when analyzing the increase of antimicrobial activity, modulation of the immune system, and promotion of cell proliferation for tissue regeneration [25][26][27][28][29][30]. Among the natural components, propolis presents a great potential application for the treatment of injuries, since its 420 compounds-with a vast majority belonging to the group of phenolic compounds, flavonoids, and phenolic acids-are responsible for performing different biological activities [31] such as antimicrobial [32], antioxidant [33], and anti-inflammatory [34] action.…”

Improving some structural and biological characteristics of bacterial cellulose by cross‐linking

“…18 BC possesses a similar chemical structure to plant cellulose; nevertheless, the cellulose of bacteria has high purity, finer fiber composition, unique strength, and more biocompatibility. 16 Due to the distinctive properties of BC, that is, high water absorption (WA), biodegradation, 19 fine biocompatibility, high porosity, 20 high water holding capacity, 21 hydrophilicity, high crystallization, 1 and strength against traction, 22 BC can be regarded as a befitting polymer for biomedical applications especially for scaffold and wound dressing fabrication. 23 BC pellicle is a fibrous three-dimensional structure, which can be easily modified by the incorporation of different types of materials that makes it an appropriate nanocomposite for biomedical applications.…”