Investigation of wound healing potential of photo-active curcumin-ZnO-nanoconjugates in excisional wound model

Aslam, Zara; Roome, Talat; Razzak, Anam; Aslam, Shazmeen; Zaidi, Midhat Batool; Kanwal, Tasmina; Sikandar, Bushra; Bertino, Massimo F.; Rehman, Khadija; Shah, Muhammad Raza

doi:10.1016/j.pdpdt.2022.102956

Cited by 11 publications

(3 citation statements)

References 83 publications

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“…Thus, the wound healing potential of visible radiated CUR-sensitized ZnO was examined using a rat excisional wound model. 165 it was observed that the wounds treated with LED-radiated groups (CUR and CURsensitized ZnO groups) showed early and increased wound closure compared to the control. Furthermore, immunohistochemical analysis showed the increased expression of CD31 on days 8 and 16 in irradiated-CUR and -CUR-sensitized ZnO groups compared to the control.…”

Section: Gel and Hydrogelmentioning

confidence: 95%

“…While ultraviolet light is essential for the photocatalytic activity of ZnO, CUR‐sensitized ZnO can be activated by radiance with visible light. Thus, the wound healing potential of visible radiated CUR‐sensitized ZnO was examined using a rat excisional wound model 165 . it was observed that the wounds treated with LED‐radiated groups (CUR and CUR‐sensitized ZnO groups) showed early and increased wound closure compared to the control.…”

Section: Gel and Hydrogelmentioning

confidence: 99%

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Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

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Section: Gel and Hydrogelmentioning

confidence: 95%

Section: Gel and Hydrogelmentioning

confidence: 99%

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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“…Conversely, ZnO-NP is categorized as a safe substance to consume by the American Food and Drug Administration (FDA). 11 This study aims to reveal more about the antibacterial effect of ZnO-NP suspension, particularly Staphylococcus aureus and its biofilm, in preventing surgical infection.…”

Section: Introductionmentioning

confidence: 99%

Suspension of zinc oxide nanoparticles (ZnO-NP) as an intraoperative wound irrigation to prevent infection after fracture fixation

et al. 2023

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Background: Infection after fracture fixation (IAFF) associated with an implant in orthopaedic surgery is a feared complication, leading to non-union, loss of function, amputation, and even mortality and morbidity to the patient. A biofilm formation on the implant surface increases the difficulty of treatment. Therefore, surgical infection prevention with an effective antiseptic solution is required. This study aims to reveal more about the antibacterial effect of ZnO-NP suspension, particularly Staphylococcus aureus and its biofilm, in preventing surgical infection. Method: An in vitro experimental study with a posttest-only control group design was used to see the antimicrobial activity and inhibitory effect of Staphylococcus aureus biofilm formation between a 20% zinc oxide nanoparticle (ZnO-NP) suspension (20 mg/mL) compared to 0.3% povidone-iodine solution. The statistical result was tested using an independent t-test antibacterial activity. Meanwhile biofilm identification was evaluated using Mann-Whitney & Kruskal Wallis test for each group. Result: 20% ZnO-NP suspension has a minimum inhibitory concentration at 4 g/mL and a minimum bactericidal concentration at 16 g/mL, same as 0.3% povidone-iodine administration and its statistically significant (p-value 0.001). Minimum biofilm inhibitory concentration was seen at a concentration of 20% ZnO-NP suspension of 2 μg, while at higher doses, it showed lysis of bacterial cells. Conclusion: 20% ZnO-NP suspension is a promising solution for preventing surgical infection due to its antibacterial and antibiofilm effects.

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Synthesis and Characterization of Novel Amphiphilic Peptide and its Application in the Development of Niosomal Formulation as a Drug Delivery Carrier for Curcumin

Karim,

Rehman,

Khan

et al. 2024

J Clust Sci

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Investigation of wound healing potential of photo-active curcumin-ZnO-nanoconjugates in excisional wound model

Cited by 11 publications

References 83 publications

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Suspension of zinc oxide nanoparticles (ZnO-NP) as an intraoperative wound irrigation to prevent infection after fracture fixation

Synthesis and Characterization of Novel Amphiphilic Peptide and its Application in the Development of Niosomal Formulation as a Drug Delivery Carrier for Curcumin

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