Investigation of Toxicological Properties of P(3HB-co-4HB) Electrospun Membranes as an Experimental Wound Dressings

Shishatskaya, Ekaterina I.; Шишацкая, Е.И.

doi:10.17516/1997-1389-0026

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For effective regeneration of injured skin, novel material scaffolds are required to fulfil the antimicrobial potential, have no toxic effects, provide good mechanical support and sufficient elasticity to fit the wound shape. Shishatskaya et al [ 132 ] reported that P(3HB- co -4HB) intended for skin repair does not change the biological value of human blood cells. Also, P(3HB- co -4HB) has no toxic effect on the membrane and blood cells, therefore the development of P(3HB- co -4HB) scaffolds has the potential to meet the requirements for tissue regeneration and bioengineering.…”

Section: Biomedical Applications Of P(3hb -Co- mentioning

confidence: 99%

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

et al. 2020

View full text Add to dashboard Cite

Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [(P(3HB-co-4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB-co-4HB) increase its practicality to be developed as functional medical substitutes. However, its applicability is sometimes limited due to its hydrophobic nature due to fewer bio-recognition sites. In this review, we demonstrate how surface modifications of PHAs, mainly P(3HB-co-4HB), will overcome these limitations and facilitate their use in diverse medical applications. The integration of nanotechnology has drastically enhanced the functionality of P(3HB-co-4HB) biomaterials for application in complex biological environments of the human body. The design of versatile P(3HB-co-4HB) materials with surface modifications promise a non-cytotoxic and biocompatible material without inducing severe inflammatory responses for enhanced effective alternatives in healthcare biotechnology. The enticing work carried out with P(3HB-co-4HB) promises to be one of the next-generation materials in biomedicines which will facilitate translation into the clinic in the future.

show abstract

Section: Biomedical Applications Of P(3hb -Co- mentioning

confidence: 99%

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

et al. 2020

View full text Add to dashboard Cite

show abstract

Investigation of Toxicological Properties of P(3HB-co-4HB) Electrospun Membranes as an Experimental Wound Dressings

Abstract: Non-woven experimental samples of wound dressings, made from natural degradable polymers, were produced and investigated. High-porous membranes were obtained by electrostatic formation of solutions of copolymers of 3-hydroxybutyrate-co-4-hydroxybutyrate

Cited by 1 publication

References 3 publications

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

Contact Info

Product

Resources

About