Investigation of Three Drugs With Neuroregenerative Effects on Inferior Alveolar Nerve Injury in Rats

Abstract

PurposeNerve injuries formed during oral and maxillofacial surgical operations occur usually by crush or tension-type damages rather than incisions or ruptures. Such nerve injuries can be treated by providing regeneration with pharmacological agents without surgical intervention. The aim of this study was to determine and compare the effects of dexamethasone, B vitamin complex, and nerve growth factor on peripheral nerve regeneration with a local application on the inferior alveolar nerve. Methods Twenty-four Wistar Albino rats weighing 220-250 grams were used in the study. Experimental animals were divided into 4 groups. According to the groups, animals were treated with saline, dexamethasone, vitamin B complex and nerve growth factor. All animals were sacrificed on the 21st day and inferior alveolar nerves were resected for microscopic examination. Results The integrity and irregularities of myelin sheaths and vacuole formation were evaluated under a light microscope. Statistical analysis was performed with SPSS version 17.0. When histopathological findings were evaluated, it was observed that dexamethasone and vitamin B application triggered regeneration. However, regeneration in the group treated with nerve growth factor was much more obvious. Conclusions Local drug applications are beneficial for regeneration in inferior alveolar nerve injury. Considering their success, studies are needed to place growth factors in clinical practice.

Chemical neurotoxicity to the inferior alveolar nerve—A rare sequela of endodontic treatment

“…Furthermore, it is recommended that steroid therapy is prescribed (step down 5‐day course of Prednisone Oral 50–40–30–20–10 mg) at the earliest identification of a traumatic IAN injury 26 . This is supported by various experimental studies which have shown steroids play an important role in reducing neuroinflammation, which can lead to accelerated functional recovery of nerves after trauma 27,28 . In severe cases, such as the one described, further treatment may involve a nerve graft 29 …”

“…26 This is supported by various experimental studies which have shown steroids play an important role in reducing neuroinflammation, which can lead to accelerated functional recovery of nerves after trauma. 27,28 In severe cases, such as the one described, further treatment may involve a nerve graft. 29…”