Investigation of the transient receptor potential channel gene expressions in metabolic syndrome

Tabur, Suzan; Öztuzcu, Serdar; Düzen, İrfan Veysel; Eraydın, Ayten; Özkaya, Mesut; Demiryürek, Abdullah Tuncay

doi:10.1530/endoabs.37.ep609

Cited by 4 publications

(2 citation statements)

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“…Moreover, the rs12472151 , rs11562975 , and rs28901637 polymorphisms of the TRPM8 gene were associated with metabolic syndrome, obesity, and cholesterol levels [ 138 , 139 , 140 ]. Variants at TRPM8, rs10166942 , and rs2362290 have been related to slower colonic transit rates, increased risk of irritable bowel syndrome, and chronic migraine [ 141 , 142 ].…”

Section: Pharmacogenomics Of Receptorsmentioning

confidence: 99%

Cannabis Pharmacogenomics: A Path to Personalized Medicine

Babayeva

Loewy

2023

CIMB

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Cannabis and related compounds have created significant research interest as a promising therapy in many disorders. However, the individual therapeutic effects of cannabinoids and the incidence of side effects are still difficult to determine. Pharmacogenomics may provide the answers to many questions and concerns regarding the cannabis/cannabinoid treatment and help us to understand the variability in individual responses and associated risks. Pharmacogenomics research has made meaningful progress in identifying genetic variations that play a critical role in interpatient variability in response to cannabis. This review classifies the current knowledge of pharmacogenomics associated with medical marijuana and related compounds and can assist in improving the outcomes of cannabinoid therapy and to minimize the adverse effects of cannabis use. Specific examples of pharmacogenomics informing pharmacotherapy as a path to personalized medicine are discussed.

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Section: Pharmacogenomics Of Receptorsmentioning

confidence: 99%

Cannabis Pharmacogenomics: A Path to Personalized Medicine

Babayeva

Loewy

2023

CIMB

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“…Studies suggest that the TRPM8 channel gene could be involved in a network of pathways, including lipid metabolism, signaling transduction, membrane transport, and regulatory pathways of genes in complex diseases, such as hypertension [185,186]. The TRPM8 gene has already been shown to have broad genomic significance due to its association with blood pressure, and the polymorphism of the TRPM8 gene may lead to an increased risk of developing hypertension [187].…”

Section: Transient Receptor Potential Melastatin Typementioning

confidence: 99%

Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

Jesus

Araujo

Alves

et al. 2023

Journal of Hypertension

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Transient receptor potential (TRP) channels are nonselective cation channels and participate in various physiological roles. Thus, changes in TRP channel function or expression have been linked to several disorders. Among the many TRP channel subtypes, the TRP ankyrin type 1 (TRPA1), TRP melastatin type 8 (TRPM8), and TRP vanilloid type 1 (TRPV1) channels are temperature-sensitive and recognized as thermo-TRPs, which are expressed in the primary afferent nerve. Thermal stimuli are converted into neuronal activity. Several studies have described the expression of TRPA1, TRPM8, and TRPV1 in the cardiovascular system, where these channels can modulate physiological and pathological conditions, including hypertension. This review provides a complete understanding of the functional role of the opposing thermo-receptors TRPA1/TRPM8/TRPV1 in hypertension and a more comprehensive appreciation of TRPA1/TRPM8/TRPV1-dependent mechanisms involved in hypertension. These channels varied activation and inactivation have revealed a signaling pathway that may lead to innovative future treatment options for hypertension and correlated vascular diseases.

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Cellular Cold Perception

Cancello

2024

Whole-Body Cryostimulation

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Investigation of the transient receptor potential channel gene expressions in metabolic syndrome

Cited by 4 publications

References 0 publications

Cannabis Pharmacogenomics: A Path to Personalized Medicine

Cannabis Pharmacogenomics: A Path to Personalized Medicine

Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

Cellular Cold Perception

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