Investigation of the teratogenic potential of a Zingiber officinale extract in the rat

Weidner, Morten Sloth; Sigwart, Katrin

doi:10.1016/s0890-6238(00)00116-7

Cited by 82 publications

(48 citation statements)

References 16 publications

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“…Subsequent study of rats using human-compatible doses of ginger showed no similar adverse effects. 39 A commonly observed side effect of ginger is reflux. In a study by Willets et al, 24 4 of the 120 subjects withdrew because of symptoms consistent with reflux.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Thomson

Corbin

Leung

2014

The Journal of the American Board of Family Medicine

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Background: Nausea and vomiting in early pregnancy (NVEP) is commonly encountered in family medicine. Ginger (Zingiber officinale) is a popular nonpharmacological treatment but consensus of its use is lacking.Methods: We conducted a meta-analysis of clinical trials using ginger for NVEP as published in PubMed and EMBASE, CINAHL, Cochrane Library, and all EBM reviews. Studies satisfying 3 criteria were selected: (1) randomized placebo-controlled design; (2) use of ginger or Z. officinale; and (3) extractable data on improvement in NVEP. Data were synthesized into pooled odd ratios based on the random effects model, and results were tabulated with the aid of Forest plots.Results: We identified 135 potentially relevant records; only 6 studies met the final criteria. Of the total 508 subjects, 256 and 252 subjects were randomly assigned to receive ginger and placebo, respectively. The use of ginger (ϳ1 g daily) for at least 4 days is associated with a 5-fold likelihood of improvement in NVEP. Heterogeneity among the clinical studies were acknowledged in the final interpretation of results.Conclusions: Despite the widespread use of ginger in the diet, its clinic value and safety profile in treating NVEP is still unknown. Our meta-analysis suggests that ginger is an effective nonpharmacological treatment for NVEP. (J Am Board Fam Med 2014;27:115-122.)

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Section: Discussionmentioning

confidence: 99%

Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Thomson

Corbin

Leung

2014

The Journal of the American Board of Family Medicine

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“…However, the result of this study showed that 5.1% students were experienced heartburn in ginger group and there were no significant differences between the two groups concerning to gastrointestinal adverse effects. Ginger is generally considered a safe herbal medicine [30]. …”

Section: Discussionmentioning

confidence: 99%

Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial

Rahnama

Montazeri

Huseini

et al. 2012

BMC Complement Altern Med

101

113

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BackgroundZingiber officinale R. rhizome (ginger) is a popular spice that has traditionally been used to combat the effects of various inflammatory diseases. The aim of this study was to evaluate the effects of ginger on pain relief in primary dysmenorrhea.MethodThis was a randomized, controlled trial. The study was based on a sample of one hundred and twenty students with moderate or severe primary dysmenorrhea. The students were all residents of the dormitories of Shahed University. They were randomly assigned into two equal groups, one for ginger and the other for placebo in two different treatment protocols with monthly intervals. The ginger and placebo groups in both protocols received 500 mg capsules of ginger root powder or placebo three times a day. In the first protocol ginger and placebo were given two days before the onset of the menstrual period and continued through the first three days of the menstrual period. In the second protocol ginger and placebo were given only for the first three days of the menstrual period. Severity of pain was determined by a verbal multidimensional scoring system and a visual analogue scale.ResultsThere was no difference in the baseline characteristics of the two groups (placebo n = 46, ginger n = 56). The results of this study showed that there were significant differences in the severity of pain between ginger and placebo groups for protocol one (P = 0.015) and protocol two (P = 0.029). There was also significant difference in duration of pain between the two groups for protocol one (P = 0.017) but not for protocol two (P = 0.210).ConclusionTreatment of primary dysmenorrhea in students with ginger for 5 days had a statistically significant effect on relieving intensity and duration of pain.Trial registrationIRCT201105266206N3

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“…After 21 days of pregnancy, there was no difference in the number of fetuses, fetal body weight, and sex ratio between ginger treatment group and vehicle control. Furthermore, the number of foetuses with parietal and occipital bone defect decreased in EV.EXT 33 treated rats [81]. …”

Section: Safety Of Zingiber Officinalementioning

confidence: 99%

Preventive and Protective Properties ofZingiber officinale(Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review

Tran

Duke

et al. 2012

Evidence-Based Complementary and Alternative Medicine

128

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Zingiber officinale (ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data from in vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, and improved carbohydrate and lipid metabolism. The most active ingredients in ginger are the pungent principles, gingerols, and shogaol. Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications. The pharmacokinetics, bioavailability, and the safety issues of ginger are also discussed in this update.

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Investigation of the teratogenic potential of a Zingiber officinale extract in the rat

Cited by 82 publications

References 16 publications

Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial

Preventive and Protective Properties ofZingiber officinale(Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review

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