Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Thomson, Maggie; Corbin, Renée; Leung, Lawrence C.

doi:10.3122/jabfm.2014.01.130167

Cited by 84 publications

(62 citation statements)

References 38 publications

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“…One meta-analysis of two studies [19,29] in this SR showed that ginger significantly decreased nausea symptoms when compared to placebo. When taking into account that other SRs [10,16,17,35,36] as well as the above-mentioned 7 concluded that ginger had beneficial effects on nausea during pregnancy (together with the findings of this SR), it is probably safe to assume that ginger has potential as a possible anti-emetic drug-alternative during pregnancy. The theoretical physiological mechanism by which ginger affects the digestive system also supports this theory.…”

Section: Discussionmentioning

confidence: 83%

A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting

Viljoen

Visser

Koen

et al. 2014

Nutr J

234

118

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Background and objectivesNausea and vomiting during pregnancy (NVP) occur commonly. Possible harmful side-effects of conventional medicine to the fetus create the need for alternative options to relieve NVP. This systematic review (SR) investigated current evidence regarding orally administered ginger for the treatment of NVP. The primary objective was to assess the effectiveness of ginger in treating NVP. The secondary objective was to assess the safety of ginger during pregnancy.MethodsA comprehensive electronic bibliographic database search was carried out. Randomized controlled trials (RCTs) of the efficacy of orally administered ginger, as treatment for NVP in pregnant women at any stage of pregnancy, published in English, were included. Two researchers independently extracted data and assessed trial quality. RevMan5 software (Cochrane Collaboration) was used for data analysis. p < 0.05 was considered statistically significant.ResultsTwelve RCTs involving 1278 pregnant women were included. Ginger significantly improved the symptoms of nausea when compared to placebo (MD 1.20, 95% CI 0.56-1.84, p = 0.0002, I2 = 0%). Ginger did not significantly reduce the number of vomiting episodes during NVP, when compared to placebo, although there was a trend towards improvement (MD 0.72, 95% CI -0.03-1.46, p = 0.06, I2 = 71%). Subgroup analyses seemed to favor the lower daily dosage of <1500 mg ginger for nausea relief. Ginger did not pose a significant risk for spontaneous abortion compared to placebo (RR 3.14, 95% CI 0.65-15.11, p = 0.15; I2 = 0%), or to vitamin B6 (RR 0.49, 95% CI 0.17-1.42, p = 0.19, I2 = 40%). Similarly, ginger did not pose a significant risk for the side-effects of heartburn or drowsiness.ConclusionsThis review suggests potential benefits of ginger in reducing nausea symptoms in pregnancy (bearing in mind the limited number of studies, variable outcome reporting and low quality of evidence). Ginger did not significantly affect vomiting episodes, nor pose a risk for side-effects or adverse events during pregnancy. Based on evidence from this SR, ginger could be considered a harmless and possibly effective alternative option for women suffering from NVP.International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42011001237.

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Section: Discussionmentioning

confidence: 83%

A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting

Viljoen

Visser

Koen

et al. 2014

Nutr J

234

118

View full text Add to dashboard Cite

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“…Research suggests that ginger is an effective antiemetic treatment for these conditions (Chaiyakunapruk et al 2006;Ryan et al 2012;Thomson et al 2014). However, most investigations use encapsulated sources of ginger, hence bypassing oral sensory stimulation.…”

Section: Nausea and Vomitingmentioning

confidence: 98%

Chemosensory Properties of Pungent Spices: Their Role in Altering Nutrient Intake

2015

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Background The general population is not compliant with national dietary recommendations for promoting health and reducing chronic disease risk. While rising obesity rates suggest that the majority of the population is overconsuming, many individuals affected with either acute or chronic diseases struggle to maintain adequate dietary intake and are at high nutritional risk. Flavor is the primary driver of food intake; however, disliked flavors are a major barrier to consumer adherence with dietary recommendations for both groups. Spices that contribute to chemical burn-such as black pepper, garlic, ginger, mustard, oregano, red pepper, and wasabi-alter food flavors. Purpose This paper explores the role of these pungent spices in altering nutrient intake across the lifespan. The role of chemical burn in manipulating dietary intake in both diseased and healthy populations is discussed. Application Implications for using pungent spices to enhance compliance with dietary manipulations are described. Proposed functions of pungent spices are maintaining, preserving, and enhancing flavor to offset the reductions in liking and palatability that are associated with dietary modifications and disease status.

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“…Recently, Thomson & coworkers [11] performed a meta-analysis of six studies with the aim to assess the clinical efficacy of ginger in nausea and vomiting in early pregnancy (NVEP) [11]. The use of ginger (1 g daily) for at least 4 days was found to be associated with a 5 fold likelihood of improvement in NVEP, thus suggesting that ginger is an effective non-pharmacological treatment for NVEP [11].…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Ginger Plus B6 Vitamin in Hyperemesis Gravidarum: Report of Two Cases

Sinagra¹,

Matrone²,

Gullo³

et al. 2017

GHOA

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Submit Manuscript | http://medcraveonline.com women. The condition progresses to hyperemesis gravidarum, which is characterized by prolonged and severe nausea, vomiting, dehydration and weight loss [2]. We report two cases of patients presenting with hyper emesis gravidarum successfully treated with a combined preparation of ginger and B 6 vitamin. Case Report Case report 1A 36-year-old nulliparous female experienced severe nausea and vomiting from early in her pregnancy. She did not have comorbidities. She was not an active smoker. Her family history for gastrointestinal diseases, motion sickness and neurological diseases was negative. She had taken oral contraceptive for 13 years before the pregnancy, without experiencing any adverse event.During this pregnancy, the patient experienced extreme nausea and vomiting (N/V) since Week 3 of pregnancy and was officially diagnosed with HG at Week 6 of pregnancy. Her Mother risk Pregnancy unique quantification of Emesis and Nausea (PUQE) scale was 10 on admission (PUQE scale ranges from 3 [no symptoms] to 15 [maximal symptoms]) [3]. Save decreased total protein and albumin, a complete metabolic panel was within normal limits. Both the neurologist and psychologist excluded neurologic and psychologic problems. Serial albumin, prealbumin and transferrin levels were measured as references for maternal nutritional status in combination with measurements of the triceps skin fold upper arm circumference and abdominal circumference. She was taking both proton pump inhibitors (PPI), ondansetron and promethezine since diagnosed with HG, with minimal effectiveness. Furthermore, the patient refused to perform an upper endoscopy and to start steroids as second-line treatment.At the time of referral (8 th week of gestation) we began our patient on a combined preparation of ginger and B 6 vitamin (1 cp containing ginger 1000 mg, gingerols 50 mg, B 6 vitamin 96 mg), 1 cp bi-daily, together with antacids. After seven days, her Mother risk PUQE score was 4. She was instructed to continue the medication, 1 cp bi-daily. The patient subsequently delivered, at gestational age of 39 weeks, a male neonate with a birth body weight of 2,900 kilos and Apgar scores of 7 and 9 at 1 minute and 5 minutes, respectively there were no neonatal complications. The placenta was intact and weighed 340 g with no evidence of fatty infiltration. The mother's nausea and vomiting subsided and her food tolerance improved after delivery. The mother was discharged from our hospital in good condition 3 days after delivery. Case ReportGastroenterol Hepatol Open Access 2017, 6(1): 00182 AbstractHyperemesis gravidarum is defined as severe nausea and vomiting persisting after the 14 th week of pregnancy it is often characterized by dehydration, electrolyte imbalance, ketonuria and weight loss of more than 5% of body weight. We report two cases of patients presenting with hyperemesis gravidarum successfully treated with a combined preparation of ginger and B 6 vitamin. Our report show that ginger is an effective non ph...

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Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Cited by 84 publications

References 38 publications

A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting

A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting

Chemosensory Properties of Pungent Spices: Their Role in Altering Nutrient Intake

Clinical Efficacy of Ginger Plus B6 Vitamin in Hyperemesis Gravidarum: Report of Two Cases

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