Investigation of the stability of tablets prepared from sucrose and citric acid anhydride utilizing response surface methodology

Behzadi, Sharareh Salar; Ölzant, Silvester; Länger, Reinhard; Koban, Christian; Unger, Frank M.; Viernstein, Helmut

doi:10.1007/s00217-005-0183-y

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Model inspection concluded that high lubricant concentrations and compression forces were detrimental for the dissolution of effervescent tablets. Behzadi et al [166] used RSM to minimize the hydrolysis of sucrose in tablets containing citric acid. Stability testing was performed using tablets with varying ratios of sucrose to citric acid and formulation process parameters, such as compression force.…”

Section: Product Formulationmentioning

confidence: 99%

Optimization Methodologies for the Production of Pharmaceutical Products

Escotet‐Espinoza

Rogers

Ierapetritou

2016

Methods in Pharmacology and Toxicology

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Finding the most beneficial conditions during the development of a given product or process is among one of the top goals for both scientist and engineers across all industries. In the pharmaceutical industry, as global competition increases and there is a higher demand for accessible quality products, it is important to focus on the improvement of product development and manufacturing. Optimization methodologies can greatly aid the production of pharmaceutical products by providing a systematic framework to process improvement. In this review, general concepts regarding the implementation of optimization methods are introduced along with examples of their application in pharmaceutical manufacturing process design and formulation development. An overview of optimization methodologies used for the improvement of batch and continuous pharmaceutical manufacturing is presented. Challenges in the application of optimization methods in pharmaceutical manufacturing are discussed along with a future outlook of the field and its place in pharmaceutical process and product design. Overall the review points to optimization as a critical component in the design of improved and effective pharmaceutical products, in alignment with the common goals of both regulatory agencies and industry.

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Section: Product Formulationmentioning

confidence: 99%

Optimization Methodologies for the Production of Pharmaceutical Products

Escotet‐Espinoza

Rogers

Ierapetritou

2016

Methods in Pharmacology and Toxicology

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“… It is used for wet granulation and has good flow (Behzadi et al, 2006).  It serves as an excellent taste masking agent (Mullarney et al, 2003).…”

Section: Sucrosementioning

confidence: 99%

Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality

Rojas¹

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This thesis project studied microcrystalline cellulose II (CII), a polymorphic form of cellulose, which has lower mechanical properties, less plastic deformation, higher elastic recovery and faster disintegration properties than microcrystalline cellulose I (CI). Also, the effects of processing and silicification on CII materials were investigated. Particle modification through spray drying, wet granulation and spheronization was employed to improve CII performance. Spray-drying (SDCII) and wet granulation (WGCII) produced materials with no difference in mechanical or disintegration properties from unprocessed CII, but did show an increase in density and particle flow. Conversely, spheronization (SPCII) showed the poorest mechanical properties compared to CII. Further, SDCII showed better dilution potential than CII. Thus the advantages of SDCII were apparent when it was mixed with a poorly compressible drug (acetaminophen) because fibrous CII was converted to spheroidal particles through spray drying. The rapid disintegration of SDCII and CII compacts was due to water wicking through capillaries followed by compact bursting. Compacts of ibuprofen mixed with SDCII and Avicel ® PH-102 had comparable disintegration rates and release profiles compared to ibuprofen formulated with commercial disintegrants and Avicel ® PH-102, especially at levels 10% w/w. Adding fumed silica into CII particles through spray drying, wet granulation (WGCII) and spheronization (SPCII) at 2-20% w/w was also studied. Silicification increased physical properties such as true density, Hausner ratio, porosity, ejection force and specific surface area of SDCII and WGCII. Other properties such as bulk and tap densities were reduced due to the amorphous and light character of fumed silica. Spheronized CII showed no change in these properties with silicification. Silicification diminished lubricant sensitivity with magnesium stearate due to the competition of SiO 2 with magnesium stearate to coat CII particles. Silicification also decreased the affinity of CII for water only at the 20% w/w level due to the few silanol groups available for water interaction compared to surface hydroxyl groups on CII alone. Particle size modification of CII was process-dependent v transformed my vision of the role of pharmaceutics and physical pharmacy for drug development. I also appreciate their financial support and the initial support provided by University of Antioquia, especially to Professors Tobon and Bedoya. I also express my gratitude to Dr. Reist for his trust, support and teaching me the value of professionalism and personalized pedagogy in the Pharmacy Practice Laboratory.

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Citric Acid Chemistry

Apelblat

2014

Citric Acid

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Investigation of the stability of tablets prepared from sucrose and citric acid anhydride utilizing response surface methodology

Cited by 5 publications

References 28 publications

Optimization Methodologies for the Production of Pharmaceutical Products

Optimization Methodologies for the Production of Pharmaceutical Products

Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality

Citric Acid Chemistry

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