Investigation of the role of complement and complement receptors in the modulation of B cell activation by a Paracoccidioides brasiliensis cell wall fraction

Biella, Carla de Agostino; Uecker, Marilei; Silva, Marcelo Fernandes da; Barbosa, José Elpídio; Silva, Célio Lopes; Crott, Luciana Simon Pereira

doi:10.1016/j.clim.2005.09.015

Cited by 3 publications

(4 citation statements)

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“…In addition, F1 with bound complement fragments triggers B‐cell activation and differentiation via complement receptors CR1 and, more importantly, CR2. Blocking of these receptors with monoclonal antibodies leads to a reduction in immunoglobulin secretion 141 …”

Section: Complement and Paracoccidioidesmentioning

confidence: 99%

“…Blocking of these receptors with monoclonal antibodies leads to a reduction in immunoglobulin secretion. 141 A further important function of the complement system during infections, namely the elimination of IC, is often disturbed in patients with PCM. The complement receptor CR1 on erythrocytes is normally responsible for binding to opsonised antigens and for a safe clearance of IC in the liver.…”

Section: Complement and Paracoccidioidesmentioning

confidence: 99%

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Complement and fungal pathogens: an update

Speth

Rambach

Würzner

et al. 2008

Mycoses

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Fungal infections are a serious complication in immunocompromised patients such as human immunodeficiency virus-infected individuals, patients with organ transplantations or with haematological neoplasia. The lethality of opportunistic fungal infection is high despite a growing arsenal of antimycotic drugs, implying the urgent need for supportive immunological therapies to strengthen the current inefficient antimicrobial defences of the immunocompromised host. Therefore, increasing effort has been directed to investigating the interplay between fungi and the host immunity and thus to find starting points for additional therapeutic approaches. In this article, we review the actual state of the art concerning the role of complement in the pathogenesis of fungal infections. Important aspects include the activation of the complement system by the fungal pathogen, the efficiency of the complement-associated antimicrobial functions and the arsenal of immune evasion strategies applied by the fungi. The twin functions of complement as an interactive player of the innate immunity and at the same time as a modulator of the adaptive immunity make this defence weapon a particularly interesting therapeutic candidate to mobilise a more effective immune response and to strengthen in one fell swoop a broad spectrum of different immune reactions. However, we also mention the 'Yin-Yang' nature of the complement system in fungal infections, as growing evidence assigns to complement a contributory part in the pathogenesis of fungus-induced allergic manifestations.

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Section: Complement and Paracoccidioidesmentioning

confidence: 99%

Section: Complement and Paracoccidioidesmentioning

confidence: 99%

Complement and fungal pathogens: an update

Speth

Rambach

Würzner

et al. 2008

Mycoses

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show abstract

“…It has been demonstrated by immunofluorescence that C3, C3a, C3d, C3g, C4, C5b-9, and factors H and B are present on the cell surface of P. brasiliensis yeasts (Munk and Silva, 1992) and that complement 3 and mannose receptors are important for phagocytosis by macrophages (Jiménez et al, 2006). Also, an opsonized cell wall preparation was able to regulate B lymphocyte by complement receptors 1 and 2, which recognize activated C3 and C4 (de Agostino Biella et al, 2006). The results concerning stimulation with whole and fractionated cell wall preparations should be viewed critically, though, taking into consideration the purity of the preparations and the fact that F1 contains chitin, proteins, and β-glucans.…”

mentioning

confidence: 99%

The Paracoccidioides Cell Wall: Past and Present Layers Toward Understanding Interaction with the Host

Puccia¹,

Vallejo²,

Matsuo³

et al. 2011

Front. Microbio.

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The cell wall of pathogenic fungi plays import roles in the interaction with the host, so that its composition and structure may determine the course of infection. Here we present an overview of the current and past knowledge on the cell wall constituents of Paracoccidioides brasiliensis and P. lutzii. These are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis, a systemic granulomatous, and debilitating disease. Focus is given on cell wall carbohydrate and protein contents, their immune-stimulatory features, adhesion properties, drug target characteristics, and morphological phase specificity. We offer a journey toward the future understanding of the dynamic nature of the cell wall and of the changes that may occur when the fungus infects the human host.

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“…Paracoccidioides brasiliensis is a dimorphic fungus pathogenic to humans, growing as yeast during infection and as mycelium in the environment. The cell wall of P. brasiliensis consists of chitin and glucan and is involved in pathogenesis (de Agostino Biella et al 2006). The percentage of chitin in P. brasiliensis ranges from 37-48% in the yeast phase and from 7-18% in the mycelial phase, indicating the importance of this carbohydrate and the enzymes involved in cell wall metabolism in dimorphism and the fungal infection process (Kanetsuna et al 1969).…”

mentioning

confidence: 99%