Investigation of the relationship between inflammatory blood parameters and rosacea and demodex infestation

Abstract

Background Rosacea is a chronic inflammatory disease. Although the etiopathogenesis of the disease has not been established, it is known that inflammation plays a prominent role in the disease. Demodex mites have been thought to have a role in the pathogenesis of rosacea by causing the occurrence of inflammatory lesions. In the literature, many studies have reported that complete blood count (CBC) parameters have been used as diagnostic biomarkers in diseases associated with inflammatory process. Aims The aim of this study was to evaluate CBC parameters in rosaceous patients with and without demodex mite and to compare with healthy controls (HCs). Patients/Methods Ninety patients followed in our clinic between January and October 2019 and 62 healthy controls matching in terms of age and sex were included in the study. CBC parameters of the patients and the HCs were compared, retrospectively. Results There was no statistically significant difference in mean platelet volume (MPV), red cell distribution width (RDW), neutrophil lymphocyte ratio, monocyte lymphocyte ratio, and platelet lymphocyte ratio levels between all patients and HCs. RDW values were significantly lower in demodex (+) rosace group, when compared to demodex (−) rosace group and HCs. Conclusions The lower RDW levels in the demodex (+) group suggested that demodex mite did not have an increasing effect on inflammation and was effective in the disease through alternative pathways.

Rosacea Treatment: Review and Update

“…The pathogenesis of rosacea is not well understood. Immune dysfunction [ 87 ], Demodex [ 88 ], ultraviolet radiation exposure [ 89 ], and vascular hyperreactivity [ 90 ] may all play a role in the pathogenesis of rosacea. The pathogenesis and related mechanisms need further exploration to develop more etiological treatment modalities.…”

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

“…[5][6][7] Other parameters such as monocyte lymphocyte ratio (MLR) and thrombocyte lymphocyte ratio (PLR) have also been reported to be used as markers. 8 Macrophages and monocytes are the most important cell types for the secretion of pro-inflammatory and pro-oxidant cytokines in the inflammation region. 9 High-density lipoprotein cholesterol (HDL) has been shown to protect endothelium cells from the negative effects of low-density lipoprotein cholesterol (LDL) and inhibit the oxidation of LDL molecules.…”

“…It has been stated that MHR ratio can be used as an indicator marker of metabolic disorders in rosacea patients. Altunisik et al 8 compared NLR, MLR and PLR ratios between rosacea patients and the HCs and reported that they did not find a significant difference between rosacea and HCs.…”

“…Neutrophil lymphocyte ratio (NLR) is calculated by using hemogram parameters and it has been reported in recent studies that it can be used as an inflammatory marker in many diseases 5‐7 . Other parameters such as monocyte lymphocyte ratio (MLR) and thrombocyte lymphocyte ratio (PLR) have also been reported to be used as markers 8 …”

Effect of classical surgical treatment under spinal anesthesia on venous thromboembolism in varicose veins patients

“…Platelets, nucleated cells synthesized from megakaryocytes, play a role in vasoconstriction, hemostasis, vascular endothelial repair, and host defense. Recent studies have shown that atherogenesis formation is also effective in the development of many hematological diseases, tumor growth factor release and metastasis [16,17].…”