Investigation of the quality of the drug Enalapril commercialized by pharmacies of manipulation in Belo Horizonte, Brazil

The proposal of this work was to investigate the effect of the radioactive complex of platinum(II) with tetracycline, [PtCl 2 (C 22 H 24 N 2 O 8 )]*, or [Tc-Pt(II)]*, on K562 cells-blood human cells of leukemia-and verify if the internal radio-chemotherapy would be able to produce additional effects compared with the non-labelled complex, [PtCl 2 (C 22 H 24 N 2 O 8 )], or [Tc-Pt(II)]. The concentration required to inhibit 50 % of cellular growth, (IC 50 ), was 2.5 ± 0.2 lM for [Tc-Pt(II)]* and 14.5 ± 0.9 lM for the non-labelled molecule [Tc-Pt(II)]. This result suggest that the [Tc-Pt(II)]* could be a potent radiosensitizer evoking a supra additive effect. Treatment using the internal radiochemotherapy may be a useful alternative to reduce the drug concentration required for effective inhibition of the tumor growth.

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“…The dead time was lower than 3 %. More details about the reactor and gamma spectra analysis can be found at [24].…”

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Leal¹,

Marzano

Pereira-Maia

et al. 2016

J Radioanal Nucl Chem

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k0-Neutron Activation Analysis at CDTN, Brazil: 27 years of history, development and main achievements

Menezes

Sabino

Jačimović

2023

J Radioanal Nucl Chem

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The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

Maharjan,

Ponganam,

Lambert

et al. 2024

PLOS Glob Public Health

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The quality of medicines for the prevention and management of hypertensive disorders of pregnancy globally is a critical challenge in the reduction of maternal mortality rate. We aimed to conduct a systematic review of available studies on the quality of the eight medicines recommended globally for the prevention and management of hypertensive disorders of pregnancy. We searched five electronic databases- Ovid MEDLINE, EMBASE, CINAHL, ProQuest and Cochrane Library, and also grey literature, without year or language limitations. Any study assessing the quality parameters (Active Pharmaceutical Ingredients, pH, sterility, solubility, impurities) of medicines by using any valid laboratory methods was eligible. Two reviewers independently screened the studies, extracted data and applied Medicine Quality Assessment Reporting Guidelines tool for quality assessment. Results were narratively reported and stratified by the drug types. Of 5669 citations screened, 33 studies from 27 countries were included. Five studies reported on the quality of magnesium sulphate—two (Nigeria and USA) found substandard medicine due to failing API specification and contaminants, respectively. Another study from Nigeria and a multi-country study (10 lower-middle- and low-income countries) found poor-quality due to failing the pH criteria. Seven of eight studies evaluating aspirin found quality issues, including degraded medicines in five studies (Brazil, USA, Yugoslavia and Pakistan). Five studies of calcium supplements found quality issues, particularly heavy metal contamination. Of 15 antihypertensives quality studies, 12 found substandard medicines and one study identified counterfeit medicines. This systematic review identified pervasive issues of poor-quality medicines across all recommended medicines used to prevent or treat hypertensive disorders of pregnancy, raising concerns regarding their safety and effectiveness.

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Investigation of the quality of the drug Enalapril commercialized by pharmacies of manipulation in Belo Horizonte, Brazil

Cited by 4 publications

References 12 publications

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

k0-Neutron Activation Analysis at CDTN, Brazil: 27 years of history, development and main achievements

The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

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