Investigation of the Production of Growth-Promoting and Growth-Inhibiting Factors by Ultra-Violet Irradiated Microörganisms

Loofbourow, John R.; Morgan, Sister Mary Norbert

doi:10.1128/jb.39.4.437-453.1940

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…Later investigations showed comparable stimulation from heat and mechanical stress. Furthermore, similar findings were also noted in mammalian liver and kidney cells as well as rodent embryos …”

Section: Early Product Testing and Applicationssupporting

confidence: 82%

“…For example, a nonirradiated mixture filtrate collected from damaged yeast cells enhanced the growth of Aerobacter aerogenes and Escherichia coli at low concentrations but was inhibitory at higher concentrations . A similar biphasic dose response was reported concerning the effect of S. aureus filtrate from damaged cells on healthy cells for the same species . Figure reveals a biphasic dose response of the concentrate “A” from the irradiated S. aureus filtrate on the growth of undamaged S. aureus .…”

Section: Biphasic Dose Responses (Hormesis) and Wound Healingsupporting

confidence: 65%

“…This biphasic dose‐response phenomenon occurred in a range of experimental situations. For example, a nonirradiated mixture filtrate collected from damaged yeast cells enhanced the growth of Aerobacter aerogenes and Escherichia coli at low concentrations but was inhibitory at higher concentrations . A similar biphasic dose response was reported concerning the effect of S. aureus filtrate from damaged cells on healthy cells for the same species .…”

Section: Biphasic Dose Responses (Hormesis) and Wound Healingsupporting

confidence: 63%

“…Hormetic dose responses were reported by Loofbourow and Dwyer and Loofbourow and Morgan in research concerning wound hormones . Growth media that were collected from microorganisms that had been slightly damaged by various types of chemical, physical, and mechanical stressors enhanced the growth of undamaged cells and did so with a biphasic dose response.…”

Section: Biphasic Dose Responses (Hormesis) and Wound Healingmentioning

confidence: 88%

“…Of particular interest to the present assessment were reports that different concentrations of the same cellular extract can produce opposite effects on yeast and bacterial growth . The biphasic dose response was not the focus of their research, but the results were so striking as to gain considerable emphasis in their evaluations.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 97%

See 4 more Smart Citations

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound healing and in attempts to validate experimental findings via clinical research. Of particular interest were the observations that wound healing could be accelerated in the 30-50% range with the dose response displaying biphasic characteristics consistent with the hormesis dose-response model. Such findings set the stage for the hormetic dose-response revolution that is occurring within the biological and biomedical sciences, including wound healing, whereby considerable research now supports the capacity for endogenous and exogenous agents to accelerate the process of wound healing and its functional performance.

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Section: Early Product Testing and Applicationssupporting

confidence: 82%

Section: Biphasic Dose Responses (Hormesis) and Wound Healingsupporting

confidence: 65%

Section: Biphasic Dose Responses (Hormesis) and Wound Healingsupporting

confidence: 63%

Section: Biphasic Dose Responses (Hormesis) and Wound Healingmentioning

confidence: 88%

Section: Early Product Testing and Applicationsmentioning

confidence: 97%

See 3 more Smart Citations

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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Getting the dose–response wrong: why hormesis became marginalized and the threshold model accepted

Calabrese

2009

Arch Toxicol

115

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The dose-response relationship is central to the biological and biomedical sciences. During the early decades of the twentieth century consensus emerged that the most fundamental dose-response relationship was the threshold model, upon which scientific, health and medical research/clinical practices have been based. This paper documents that the scientific community made a fundamental error on the nature of the dose response in accepting the threshold model and in rejecting the hormetic-biphasic model, principally due to conflicts with homeopathy. Not only does this paper detail the underlying factors leading to this dose response decision, but it reveals that the scientific community never validated the threshold model throughout the twentieth century. Recent findings indicate that the threshold model poorly predicts responses in the low dose zone whereas its dose response "rival", the hormesis model, has performed very well. This analysis challenges a key foundation upon which biological, biomedical and clinical science rest.

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Borderland Problems in Biology and Physics

Loofbourow

1940

Rev. Mod. Phys.

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Investigation of the Production of Growth-Promoting and Growth-Inhibiting Factors by Ultra-Violet Irradiated Microörganisms

Cited by 7 publications

References 8 publications

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Getting the dose–response wrong: why hormesis became marginalized and the threshold model accepted

Borderland Problems in Biology and Physics

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