Investigation of the phytochemical composition and antioxidant properties of chinar (Platanus orientalis L.) leaf infusion against ethanol-induced oxidative stress in rats

Doğan, Abdulahad; Anuk, Özgür Ozan

doi:10.1007/s11033-019-04741-7

Cited by 18 publications

(26 citation statements)

References 51 publications

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“…The liver has important antioxidant enzymes, such as SOD, GSH-PX, GST etc. Excessive alcohol intake reduces the activity of antioxidant enzymes in the liver, destroys the oxidation–antioxidant balance of the body, thereby causing oxidative stress which further leads to a chain reaction of lipid peroxidation, mitochondrial function damage, endoplasmic reticulum stress and immune inflammation caused by liver damage [44]. MDA is generally considered to be an important marker of lipid peroxidation [35].…”

Section: Discussionmentioning

confidence: 99%

Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats

Qiao

Liu

et al. 2019

Molecules

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The present study was envisaged to investigate the chemical constituents and the intervention effects of Portulaca oleracea extract (POE) on acute alcoholic liver injury of rats. The chemical composition of POE was detected by high performance liquid chromatography (HPLC). Sixty male Wistar rats were divided into 6 groups: Normal control (NC) group, acute alcoholic liver injury model group (ALI), low, medium and high dose of POE (25, 50, 100 mg/kg) groups and bifendate (BF, 3.75 mg/kg) group. Each group was given by intragastrical administration for 7 days. Alcoholic liver injury was induced in the experimental model by administering 50% ethanol at 8 mL/kg and repeated administration after 6 h, for a period of 7 days. The results showed that pretreatment with POE significantly reduced the ethanol-elevated serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and triglyceride (TG). The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in liver were enhanced followed by administration of POE, while the content of nitric oxide (NO) and malondialdehyde (MDA) was found to decrease. Hepatic content of tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) was also reduced by POE treatment. These results indicated that POE could increase the antioxidant capacity and relieve the inflammatory injury of the liver cells induced by ethanol. Meanwhile, in our study, POE reduced the expression of miR-122, acetyl coenzyme A carboxylase (ACC) 1 mRNA and protein and increased the expression of lipoprotein lipase (LPL) mRNA and protein in liver, which indicated that POE could improve the lipid metabolism disorder induced by ethanol. Our findings suggested that POE had protective effects on acute alcoholic liver injury of rats.

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Section: Discussionmentioning

confidence: 99%

Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats

Qiao

Liu

et al. 2019

Molecules

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“…The flower extract of P. oleracea possessed significant antioxidant and protective effects against DNA damage induced by necrotic effects (Dogan and Anuk, 2019). V. vinifera fruits exhibit anti-asthmatic activity by inhibiting cellular response and subsequent production of inflammatory cytokines (Arora et al, 2016).…”

Section: Sharbat Rooh Afzamentioning

confidence: 99%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory distress syndrome (ARDS) caused by systemic inflammatory reactions due to the excessive release of pro-inflammatory cytokines and chemokines by the immune effector cells. In India too, it is spreading very rapidly, although the case fatality rate is below 1.50% (https://www.statista.com), which is markedly less than in other countries, despite the dense population and minimal health infrastructure in rural areas. This may be due to the routine use of many immunomodulator medicinal plants and traditional AYUSH formulations by the Indian people. This communication reviews the AYUSH recommended formulations and their ingredients, routinely used medicinal plants and formulations by Indian population as well as other promising Indian medicinal plants, which can be tested against COVID-19. Special emphasis is placed on Indian medicinal plants reported for antiviral, immunomodulatory and anti-allergic/anti-inflammatory activities and they are categorized for prioritization in research on the basis of earlier reports. The traditional AYUSH medicines currently under clinical trials against COVID-19 are also discussed as well as furtherance of pre-clinical and clinical testing of the potential traditional medicines against COVID-19 and SARS-CoV-2. The results of the clinical studies on AYUSH drugs will guide the policymakers from the AYUSH systems of medicines to maneuver their policies for public health, provide information to the global scientific community and could form a platform for collaborative studies at national and global levels. It is thereby suggested that promising AYUSH formulations and Indian medicinal plants must be investigated on a priority basis to solve the current crisis.

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“…In the research conducted in the models of chronic alcohol abuse in adults, the significant influence of alcohol consumption on the markers of oxidative stress and liver inflammation was proven [17,18], but such an effect was not studied so far in developing organisms, as well as for the alcoholic beverages other than ethanol. As such studies analyzing these factors should be conducted in the animal models of alcohol abuse in adolescents, and not in human subjects, due to ethical issues, the aim of the present study was to assess the influence of alcohol consumption on the markers of oxidative stress and liver inflammation in the animal model of prolonged alcohol consumption in adolescents using various alcoholic beverages.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages

et al. 2020

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Typical alcohol consumption begins in the adolescence period, increasing the risk of alcoholic liver disease (ALD) in adolescents and young adults, and while the pathophysiology of ALD is still not completely understood, it is believed that oxidative stress may be the major contributor that initiates and promotes the progression of liver damage. The aim of the present study was to assess the influence of alcohol consumption on the markers of oxidative stress and liver inflammation in the animal model of prolonged alcohol consumption in adolescents using various alcoholic beverages. In a homogenic group of 24 male Wistar rats (4 groups—6 animals per group), since 30th day of life, in order to mimic the alcohol consumption since adolescence, animals received (1) no alcoholic beverage (control group), (2) ethanol solution, (3) red wine, or (4) beer (experimental groups) for 6 weeks. Afterwards, the activities of alcohol dehydrogenase (ADH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as well as levels of cytochrome P450-2E1 (CYP2E1), thiobarbituric acid-reactive substances (TBARS), protein carbonyl groups, tumor necrosis factor-α (TNF-α), and interleukine-10 (IL-10) were measured in liver homogenates. The difference between studied groups was observed for CYP2E1 and protein carbonyl groups levels (increased levels for animals receiving beer compared with control group), as well as for ALT activity (decreased activity for animals receiving beer compared with other experimental groups) (p < 0.05). The results suggested that some components of beer, other than ethanol, are responsible for its influence on the markers of oxidative stress and liver inflammation observed in the animal model of prolonged alcohol consumption in adolescents. Taking this into account, beer consumption in adolescents, which is a serious public health issue, should be assessed in further studies to broaden the knowledge of the progression of liver damage caused by alcohol consumption in this group.

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Investigation of the phytochemical composition and antioxidant properties of chinar (Platanus orientalis L.) leaf infusion against ethanol-induced oxidative stress in rats

Cited by 18 publications

References 51 publications

Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats

Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages

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