Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages

Kołota, Aleksandra; Głąbska, Dominika; Oczkowski, Michał; Gromadzka-Ostrowska, Joanna

doi:10.3390/nu12010158

Cited by 21 publications

(16 citation statements)

References 59 publications

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“…10% (vol./vol.) ethanol solution, as in the last stage of acclimatization, as in the previously published studies [38,39]. The wine was chosen on the basis of its characteristics, with the aim to find the wine which is broadly available and relatively cheap, but also characterized by a simple flavor, which results from the fact that for adolescents abusing alcohol, a price is among the most important determinants of its consumption.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Association between Intake of Red Wine Polyphenols and Oxidative Stress Parameters in the Liver of Growing Male Rats

et al. 2020

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Red wine is a complex alcoholic beverage containing various substances, including those of a potential health-promoting properties, such as polyphenols, responsible for the sensory features of wine. Their potential positive influence is associated with possibility of antioxidative, anti-inflammatory, anticancer, immunomodulating, and antiallergenic effects, but at the same time, there is a possibility of their pro-oxidative effect. In spite of the fact that in adolescence alcohol may be highly damaging, as it may disturb the development, it is abused frequently. The aim of the study was to verify the association between red wine consumption as well as dietary polyphenol intake with wine and the oxidative stress parameters in the liver of growing male rats. The growing male Wistar rats were studied, while divided into three groups of six animals, receiving red wine in a solution characterized by 10% of ethanol content since 30th day of life, for two, four, and six weeks. The alcohol intake was controlled and the content of total phenolic compounds, selected phenolic acids (hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, and sinapic acid), total anthocyanidins and selected anthocyanins (cyanidin, cyanidin 3-glucoside, cyanidin 3-rutinoside, delphinidin, and pelargonidin) were assessed. At the same time, for the liver homogenates, the levels of Thiobarbituric Acid Reactive Substances (TBARS) and protein carbonyl groups were verified. The analysis revealed statistically significant influence of red wine intake, as well as of supply of phenolic acids (hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, and sinapic acid), and anthocyanins (cyanidin, cyanidin 3-glucoside, cyanidin 3-rutinoside, delphinidin, and pelargonidin) on TBARS and protein carbonyl groups level (R > 0.80; p < 0.05), but the influence was stated only for the period of two weeks. The obtained results may suggest pro-oxidative effect of both ethanol and polyphenols for the liver of the growing male rats. At the same time, for the periods of four and six weeks, no influence on TBARS and protein carbonyl groups level was observed (p > 0.05), which may allow to suppose an adaptive mechanism of the growing organism while the ethanol and polyphenols exposition is prolonged. Further studies are required to confirm the mechanism of the pro-oxidative effect of polyphenols contained in red wine for the liver of growing organism.

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Section: Methodsmentioning

confidence: 99%

Analysis of Association between Intake of Red Wine Polyphenols and Oxidative Stress Parameters in the Liver of Growing Male Rats

et al. 2020

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“… 76 What is more, consuming a large amount of ethanol induces microsomal ethanol metabolism by cytochrome P4502E1 (known as CYP2E1) and leads to additional production of acetaldehyde, as well as an increase in free radicals that can result in cell death, DNA damage, and even production of other carcinogenic substances. 80 , 81 Other hypothesized pathways have included the transactivator protein X that is encoded by HBV and remolded to the extracellular matrix through hypoxia-inducible factor-1α (HIF-1α) target genes and the lysyl oxidase (HIF-1α/LOX) pathway to promote HCC metastasis. 82 The ALDH2-acetaldehyde-redox-AMP-activated protein kinase (AMPK) axis participates in the regulation of ACH levels, which is activated by ALDH2.…”

Section: Related Liver Diseasesmentioning

confidence: 99%

Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis

Wang¹,

Chang²,

Li³

et al. 2021

Journal of Clinical and Translational Hepatology

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Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease. ALDH2 gene mutations exist in about 8% of the world’s population, with the incidence reaching 45% in East Asia. The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde, facilitating the progression of other liver diseases, including non-alcoholic fatty liver diseases, viral hepatitis and hepatocellular carcinoma, through adduct formation and inflammatory responses. In this review, we seek to summarize recent research progress on the correlation between ALDH2 gene polymorphism and multiple liver diseases, with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.

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“…was maintained by healthy individuals. However, excessive alcohol intakes causes excessive hepatic toxic acetaldehyde accumulation, contributes excessive free radicals production, which breaks intracellular balances between oxidation and antioxidation, activates lipid peroxidation, changes the permeability and fluidity of cell membranes, and contributes to cell damages or even apoptosis (Kolota et al, 2020;Zavodnik et al, 2019).…”

Section: Ta B L E 2 Effect Of Ryr On Serum Lipid Parameters In Mice Smentioning

confidence: 99%

Red yeast rice prevents chronic alcohol‐induced liver disease by attenuating oxidative stress and inflammatory response in mice

et al. 2021

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Alcoholic liver disease (ALD) is characterized by dyslipidemia, hepatic steatosis, steatohepatitis, edema, necrosis, etc. Studies have reported that some dietary nutrition factors have beneficial effects in improving ALD. Red yeast rice (RYR), a traditional herbal supplement, has been confirmed to lower cholesterol mainly due to its component monacolin K. However, the effect of RYR on ALD has not been investigated.In this study, mice were supplemented with a daily oral gavage of 4 g/kg 50% ethanol for 8 weeks to induce a chronic ALD. RYR (150 mg kg −1 day −1 ) was supplied to ALD mice in treatment group. The results showed that RYR supplementation significantly attenuated hyperlipidemia, elevated circulating inflammatory cytokines, hepatic structural damage, and oxidative stress in mice supplemented with alcohol with no effects on body weight. Moreover, RYR significantly suppressed alcohol-induced hepatic NF-κB activation and apoptosis. Our results suggest that RYR is capable of preventing ALD mainly by attenuating hepatic oxidative stress and inflammatory response. Practical applicationsRYR was known for cholesterol-lowering effect through its main component monacolin K. The current study revealed that RYR was capable of ameliorating ALD, which is characterized by profound dyslipidemia, hepatic steatosis, steatohepatitis, edema, etc. Our results indicated that the protective effect of RYR on ALD is largely achieved by regulating lipid metabolism, and closely related to the anti-inflammatory and antioxidant effects of RYR. This study provides research foundation for the development of RYR-related food or pharmaceutical products, especially targeting for ALD.

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Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages

Cited by 21 publications

References 59 publications

Analysis of Association between Intake of Red Wine Polyphenols and Oxidative Stress Parameters in the Liver of Growing Male Rats

Analysis of Association between Intake of Red Wine Polyphenols and Oxidative Stress Parameters in the Liver of Growing Male Rats

Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis

Red yeast rice prevents chronic alcohol‐induced liver disease by attenuating oxidative stress and inflammatory response in mice

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