Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

Cengiz, Nureddin; Kavak, Servet; Güzel, Ali İrfan; Özbek, Hanefí; Bektaş, Hava; Him, Aydin; Erdoğan, Ender; Balahoroğlu, Ragıb

doi:10.1007/s00232-012-9494-7

Cited by 22 publications

(13 citation statements)

References 18 publications

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“…CCl 4 -induced liver injury is the most commonly used experimental model to evaluate the hepato-protective effect of natural products [28]. There are many side effects of Western medicines that have been reported for the treatment of liver injury [29]. Therefore, natural medicines have become a future potential therapeutic hope for controlling liver disease.…”

Section: Discussionmentioning

confidence: 99%

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

Munakarmi

Chand

Shin

et al. 2020

IJMS

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3,3′-Diindolylmethane (DIM), a metabolic product of indole-3-carbinol extracted from cruciferous vegetables exhibits anti-inflammatory and anti-cancer properties. Earlier, the product has been demonstrated to possess anti-fibrotic properties; however, its protective effects on liver injury have not been clearly elucidated. In this study, we postulated the effects and molecular mechanisms of action of DIM on carbon tetrachloride (CCl4)-induced liver injury in mice. Acute liver injury was induced by a single intraperitoneal administration of CCl4 (1 ml/kg) into mice. DIM was injected via subcutaneous route for three days at various doses (2.5, 5 and 10 mg/kg) before CCl4 injection. Mice were sacrificed and serum was collected for quantification of serum transaminases. The liver was collected and weighed. Treatment with DIM significantly reduced serum transaminases levels (AST and ALT), tumor necrosis factor-α (TNF-α) and reactive oxygen species (ROS). CCl4- induced apoptosis was inhibited by DIM treatment by the reduction in the levels of cleaved caspase-3 and Bcl2 associated X protein (Bax). DIM treated mice significantly restored Cytochrome P450 2E1, nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression in CCl4 treated mice. In addition, DIM downregulated overexpression of hepatic nuclear factor kappa B (NF-κB) and inhibited CCl4 mediated apoptosis. Our results suggest that the protective effects of DIM against CCl4- induced liver injury are due to the inhibition of ROS, reduction of pro-inflammatory mediators and apoptosis.

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Section: Discussionmentioning

confidence: 99%

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

Munakarmi

Chand

Shin

et al. 2020

IJMS

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“…They are not quotable, produce incoherent toxicity, fail to generate a clinically significant lesion and require supportive therapy. Carbontetrachloride have e ARES between RES groups difference were significant (p<0.008); f K between RES groups difference were significant (p<0.008) the inconsistent results between experiments and across species (Cengiz et al, 2013, Wang et al, 2013. Lee et al (2012) reported that resveratrol treatment partially prevented carbon tetrachloride-induced acute liver damage (Lee et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Gurocak

Karabulut²,

Karadağ³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest. We here aimed to evaluate whether resveratrol could protect the liver tissues from the effects of AOM. Materials and Methods: The study was conducted in 4 groups, each consisting of seven rats, the first receiving only AOM (2 times per week, 5 mg/kg), group 2 AOM and resveratrol (2 times a week, 20 mg/kg), group 3 assessed only as a control and group 4 administered only resveratrol. At the end of the seventh week, the rats were sacrificed. Rat liver MDA, NO, GSH levels were analyzed biochemically, as well as the tissues being evaluated histopathologically. Results: MDA and NO increased in AOM group as signs of increased oxidative stress. The group concomitantly administered resveratrol was been found to be significantly decreased in MDA and NO levels and increased in GSH activity. However, there were no significant findings on histopathological evaluation. Conclusions: In the light of these results, resveratrol appears to exert protective effect on oxidative stress in the liver tissue due to deleterious effects of chemical carcinogens.

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“…Currently, there is no way to compensate for the absence of liver function in the long term and massive hepatic destruction often necessitates the need for liver transplantation [2]. There is therefore an intensive search of safe, affordable and readily available agents that can protect the liver from fulm inant damage [3]. Liver damage can be prevented by reducing the effect of reactive metabolites using antioxidants [4].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Hepatoprotective Potential of Aqueous Fruit Pulp Extract of Adansonia digitata against CCL4 Induced Liver Damage in Rats

Said

Aliyu

Mashi

et al. 2020

AJBGMB

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Aim:The current study was carried out to evaluate the hepatoprotective effects of aqueous extract of Adansonia digitata fruit pulp on carbon tetrachloride (CCl 4 ) induced liver damage in rats. Place and Duration of Study: Methodology: A. digitata fruit pulp was extracted by maceration using water; and a concentration of 100 mg/ml was used. Two doses of the aqueous extract (200 mg/kg and 300 mg/kg) and Livoline Sa'id et al.; AJBGMB, 3(3): 12-21, 2020; Article no.AJBGMB.54697 13 (25 mg/kg) were used to investigate their hepatoprotective effects on CCl 4 -induced hepatotoxicity in rats. Results: The two doses of the plant extract showed dose-dependent hepatoprotective effect on CCl 4 -induced hepatotoxicity, as evident by the significant reduction (P<0.05) in serum levels of AST, ALT, ALP and bilirubin along with the improved histopathological liver sections compared to CCl 4treated animals. Conclusion: Due to its hepatoprotective potentials, A. digitata extract may be used to develop standard treatment drugs against some liver disorders when it is further evaluated through extensive researches. Original Research Article

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Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

Cited by 22 publications

References 18 publications

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Phytochemical Screening and Hepatoprotective Potential of Aqueous Fruit Pulp Extract of Adansonia digitata against CCL4 Induced Liver Damage in Rats

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