Investigation of the hair of patients with scalp psoriasis using atomic force microscopy

Shin, Min Kyung; Kim, K. S.; Ahn, Jae-Jun; Kim, N. I.; Park, H.-K.; Haw, Choong Rim

doi:10.1111/j.1365-2230.2011.04212.x

Cited by 11 publications

(10 citation statements)

References 16 publications

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“…Kim et al used more sensitive atomic force microscopy (AFM) to study the surface morphology of psoriasisderived hair samples compared to normal hair. These studies [12,13] demonstrated that psoriatic hair had thicker cuticle edges, an overall rougher surface and more surface pitting.…”

Section: Psoriasismentioning

confidence: 99%

Role of scalp health in achieving optimal hair growth and retention

Tosti

Schwartz

2021

Intern J of Cosmetic Sci

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We have conducted a thorough review of the literature to assess the evidence for supporting a cause-and-effect linkage between scalp condition and resultant hair condition.Over 20 epidemiological studies have been published covering a wide range of abnormal scalp conditions in which consequent impacts to the hair have been documented. A treatment study was conducted to demonstrate not only that impaired scalp condition led to impaired hair quality but that the impacts to hair are reversible upon normalization of the scalp condition. A proposed explanation involves the impact of scalp oxidative stress, which is part of the etiology of these scalp conditions as well as normal aging, in interfering with the normal keratinization of the pre-emergent hair cuticle. This perturbed cuticle impedes normal fiber anchorage and emerges more brittle and fragile than normal cuticle leading to accelerated physical degradation, mirroring the effects of chronological aging of the hair fiber. The consequences of the rapid cuticle degradation result in hair that is more vulnerable to mechanical insults and compromised overall quality. RésuméNous avons mené un examen approfondi de la littérature médicale pour évaluer les preuves étayant un lien de cause à effet entre l'état du cuir chevelu et celui des cheveux. Plus de 20 études épidémiologiques ont été publiées, couvrant un large éventail d'affections du cuir chevelu pour lesquelles des impacts conséquents sur les cheveux ont été documentés. Une étude de traitement a été menée pour démontrer non seulement qu'une altération du cuir chevelu entraînait une altération de la qualité des cheveux, mais aussi que les impacts sur les cheveux étaient réversibles après normalisation de l'état du cuir chevelu. Une explication proposée inclut l'impact du stress oxydatif sur le cuir chevelu, qui fait partie de l'étiologie de ces affections du cuir chevelu ainsi que du vieillissement normal, en interférant avec la kératinisation normale de la cuticule du cheveu à son point d'émergence. Cette cuticule perturbée gêne l'ancrage normal des fibres et fait émerger des cuticules plus fragiles et friables que la normale, entraînant une dégradation physique accélérée, reflet des effets du vieillissement chronologique des fibres capillaires. La dégradation rapide de la cuticule rend les cheveux plus vulnérables aux agressions mécaniques et compromet leur qualité globale.

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Section: Psoriasismentioning

confidence: 99%

Role of scalp health in achieving optimal hair growth and retention

Tosti

Schwartz

2021

Intern J of Cosmetic Sci

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“…Scalp psoriasis is associated with significant abnormalities in the HF epithelium and with sebaceous gland atrophy (Figure 1B), 3,[26][27][28][29] and the hair shafts of patients with scalp psoriasis can exhibit the same pits as in their nails (Table 1). 30 There may even be a distinct follicular variant of psoriasis. 1,31,32 Yet, overall, only in a small minority of patients scalp psoriasis leads to marked effluvium or psoriatic alopecia.…”

Section: The Hair Folli Cle-psoria S Is a Xis: Clinic Al And His Topa...mentioning

confidence: 99%

The hair follicle‐psoriasis axis: Shared regulatory mechanisms and therapeutic targets

Suzuki

Ito

Gilhar

et al. 2021

Experimental Dermatology

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Physicians and investigators interested in either psoriasis or hair growth rarely interact to discuss pathways and mechanisms of potential common interest. And yet, it has long been recognized that both fields intersect closely and show more overlap than is widely appreciated. [1][2][3][4][5][6][7][8][9] Here, we review the relevant literature that points to a special relationship between the hair follicle (HF) and psoriasis and explain why a systematic re-examination of this axis is clinically relevant and promises to enrich both psoriasis and hair research.After we had first postulated that the induction of a psoriatic epidermal lesion and of anagen hair growth share selected "switch-on" mechanisms, 2 this concept was re-voiced in part two decades later 7 yet remains largely ignored and has not been rigorously probed until

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“…Conversely, the length of the anagen phase is extended at the site of some psoriatic lesions. In addition, the hair structure is possibly affected by psoriasis [64, 65]. All these features are conveniently explored using the trichogram method which is minimally invasive, cheap, and rapid.…”

Section: Scalp Psoriasismentioning

confidence: 99%

Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease

Hermanns‐Lê

Berardesca

Pierard

et al. 2012

Journal of Biomedicine and Biotechnology

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In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.

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Investigation of the hair of patients with scalp psoriasis using atomic force microscopy

Cited by 11 publications

References 16 publications

Role of scalp health in achieving optimal hair growth and retention

Role of scalp health in achieving optimal hair growth and retention

The hair follicle‐psoriasis axis: Shared regulatory mechanisms and therapeutic targets

Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease

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