Investigation of the frequency of the mutant CCR5-Δ32 allele related to HIV resistance in Turkey

Abstract

In this paper a variational study of a tunnelling exciton (Frenkel exciton) coupled to an arbitrary number of phonon modes is presented. The results of our model are presented both for weak nonadiabatic cases and for strong cases; and we come to the conclusion that the tunnelling reduction factor, the ground state energy of the tunnelling exciton-phonons system, and the mean number of ground state phonons, as the functions of the exciton-phonons coupling strength, are continuous, a condition that does not apply in cases of the tunnelling exciton-phonons models presented in the previous studies. In comparison with the previous studies, the presented model leads to a significant decrease of the ground state energy both of the small polaron and of the tunnelling exciton-phonons system, mainly for weak non-adiabatic cases.

Prevalence of CCR5delta32 in Northeastern Iran

“…Discovery of CCR5∆32 has opened a new field in the treatment of HIV-1 infection. In this case, the investigation of allele distribution in various populations is informative [13]. The CCR5 variations could explain why some people are more susceptible to AIDS than others [11, 14].…”