“…Since its first report in 1971 [35], the on-line EC/MS coupling was predominantly exploited for the identification of the emerging stable and/or transient (radical-cation or radical-anion) reaction products [36][37][38][39]. Nowadays, EC/MS grew into a powerful technology of wide applicability, such as: signal enhancement in MS, proteomics, study of DNA damage, testing of cosmetics on skin sensitizing effects, predicting the degradation and persistence of pollutants, and last, but not least, mimicking drug and xenobiotic metabolism [40,41].…”