Diabetes mellitus is a group of metabolic disorders characterized by distinct pathogenic mechanisms that result in hyperglycemia. 1 Type 2 diabetes mellitus (T2DM) is associated with several complications and comorbidities, including diabetic retinopathy, loss of vision, diabetic nephropathy, lower limb amputation, and cardiovascular disease mortality. 2 Type 2 diabetes accounts for nearly 85-95% of total reported cases of diabetes. Obesity and physical inactivity increase the risk of developing T2DM, which is exacerbated by age. 3 Type 2 diabetes mellitus is a complex disease with several pathophysiological abnormalities, including decreased islet function and insulin resistance, resulting in reduced glucose tolerance and abnormally high fasting hepatic glucose production. 4 Metformin is one of the oral hypoglycemic medications, which include biguanides, sulfonylurea, and thiazolidinedione, which are commonly used to treat T2DM. It improves insulin sensitivity and has the unique properties of aiding weight loss and decreasing appetite. 5 L-carnitine is a natural substance that transports long-chain fatty acids from the cytoplasm to the mitochondrial matrix for β-oxidation in diverse tissues. 6 The liver is one of the primary organs for the production of endogenous carnitine from lysine, methionine, and ascorbate. 7 The presence of adequate carnitine concentrations in the intracellular compartment is essential for normal fatty acid metabolism, which preferentially uses