Investigation of the effect of polymers on dermal foam properties using the QbD approach

Falusi, Fanni; Budai-Szűcs, Mária; Csányi, Erzsébet; Berkó, Szilvia; Spaits, Tamás; Csóka, Ildikó; Kovács, Anita

doi:10.1016/j.ejps.2022.106160

Cited by 9 publications

(1 citation statement)

References 34 publications

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“…The exact composition of different foam formulations is shown in Table 3. The type and the concentration of the surfactants and preservative were chosen based on our earlier study [23]. + the component is in the formulation, -the component is not in the formulation.…”

Section: Composition and Preparation Of Foam Samplesmentioning

confidence: 99%

Application of Xanthan Gum and Hyaluronic Acid as Dermal Foam Stabilizers

Falusi

Berkó

Kovács

et al. 2022

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Foams are increasingly popular in the field of dermatology due to their many advantages such as easy spreading, good skin sensation, and applicability in special skin conditions. One of the critical points of foam formulation is the choice of the appropriate stabilizing ingredients. One of the stability-increasing strategies is retarding the liquid drainage of liquid films from the foam structure. Therefore, our aim was the application of different hydrogel-forming polymers in order to retain the stabilizing liquid film. Dexpanthenol and niacinamide-containing foams were formulated, where xanthan gum and hyaluronic acid were used as foam-stabilizing polymers. Amplitude (LVE range) and frequency sweep (G’, G”, tanδ, and frequency dependency) were applied as structure- and stability-indicating rheological parameters. The rheological data were compared with the results of the cylinder method, microscopical images, and the spreadability measurements.

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Section: Composition and Preparation Of Foam Samplesmentioning

confidence: 99%