Investigation of the dye concentration influence on the lasing wavelength and threshold for a micro-fluidic dye laser

Helbo, Bjarne; Kragh, Søren; Kjeldsen, Bastian Gaardsvig; Reimers, Jakob Leffland

doi:10.1016/j.sna.2003.10.007

Cited by 17 publications

(9 citation statements)

References 4 publications

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“…4(a). Such red-shift of the blue-end of the edge-emitted fluorescence results in a convenient gain-tuning mechanism since the gain peak red-shifts accordingly for increasing chromophore densities [14]. The tuning of the centre wavelength of the laser emission spectrum is illustrated in Fig.…”

Section: Characterisationmentioning

confidence: 99%

Fluidic fibre dye lasers

Vasdekis¹,

Town²,

Turnbull³

et al. 2007

Opt. Express

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We report the demonstration of compact fluidic fibre lasers based on capillary tubes and photonic crystal fibres, featuring single channel and multiple laterally integrated fluidic lasers respectively. Their preparation was based on capillary action and lasing occurred without the need for external mirrors or lithographically defined microstructures. The fibre lasers were found to be tunable by varying the chromophore density in the liquid core and a functional wavelength selectivity mechanism inherent in both types of lasers provided a long free spectral range that does not correspond to the length of the fibres. The enhanced mode spacing is attributed to a Vernier resonant effect.

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Section: Characterisationmentioning

confidence: 99%

Fluidic fibre dye lasers

Vasdekis¹,

Town²,

Turnbull³

et al. 2007

Opt. Express

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“…A better detector with a larger dynamic range and a narrow band-pass filter can be used to further improve the SNR in the image. Finally, since the laser performance (such as lasing threshold and peak wavelength) depends on the dye concentration 16,43 , the labeling process needs to be standardized. The cavity length may also affect the lasing performance.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Laser Recording of Subcellular Neuron Activities

Chen

Zhu

et al. 2019

Preprint

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Advances in imaging and recording of neural activities with a single neuron resolution have played a significant role in understanding neurological diseases in the past decade. Conventional methods relying on patch-clamp and electrodes are regarded as invasive, whereas fluorescence-based imaging tools are useful but still suffer from a low signal-to-noise ratio and low sensitivity. Here we developed a novel optical imaging and recording system by employing laser emissions to record the action potentials in single neurons and neuronal networks caused by subtle transients (Ca2+concentration) in primary neuronsin vitrowith a subcellular and single-spike resolution. By recording the laser emissions from neurons, we discovered that lasing emissions could be biologically modulated by intracellular activities and extracellular stimulation with >100-fold improvement in detection sensitivity over traditional fluorescence-based measurement. Finally, we showed that ultrasound can wirelessly activate neurons adsorbed with piezoelectric BaTiO3nanoparticles, in which the neuron laser emissions were modulated by ultrasound. Our findings show that ultrasound stimulation can significantly increase the lasing intensity and neuron network response. This work not only opens the door to laser emission recording of intracellular dynamics in neuronal networks but may provide an ultra-sensitive detection method for brain-on-chip applications, optogenetics, and neuro-analysis.

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“…Such a structure has been used to show a distributed feedback dye laser 35 ( Fig. 4) -one of several optofluidic dye lasers that have been demonstrated recently [36][37][38] . As a class of optofluidic devices, these lasers are useful on their own and constitute an important set of enabling optofluidic platform tools.…”

Section: Fluids In Solidsmentioning

confidence: 99%

Developing optofluidic technology through the fusion of microfluidics and optics

Psaltis

Quake

Yang

2006

Nature

1,569

929

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We describe devices in which optics and fluidics are used synergistically to synthesize novel functionalities. Fluidic replacement or modification leads to reconfigurable optical systems, whereas the implementation of optics through the microfluidic toolkit gives highly compact and integrated devices. We categorize optofluidics according to three broad categories of interactions: fluid-solid interfaces, purely fluidic interfaces and colloidal suspensions. We describe examples of optofluidic devices in each category.Optofluidics refers to a class of optical systems that are synthesized with fluids. Fluids have unique properties that cannot be found in solid equivalents, and these properties can be used to design novel devices. Examples of such properties include: the ability to change the optical property of the fluid medium within a device by simply replacing one fluid with another; the optically smooth interface between two immiscible fluids; and the ability of flowing streams of miscible fluids to create gradients in optical properties by diffusion. Most optical systems are currently made with solid materials such as glasses, metals and semiconductors, but there are cases in which it has been advantageous to use fluids. The oil-immersion microscope 1 , liquid mirrors for telescopes 2 , liquid-crystal displays 3 and electrowetting lenses 4 are good examples. Here we describe the various methods used to implement optofluidic devices with recently developed microfluidic technologies that allow accurate control of liquids on small spatial scales. Integration and reconfigurability are two major advantages associated with optofluidics. Whereas microfluidics has made it possible to integrate multiple fluidic tasks on a chip, most optical components, such as the light source, sensors, lenses and waveguides, remained off the chip. Optofluidic integration combines optics and microfluidics on the same chip by building the optics out of the same fluidic toolkit. The second advantage of optofluidics lies in the ease with which one can change the optical properties of the devices by manipulating fluids.Microfluidics is a burgeoning field with important applications in areas such as biotechnology, chemical synthesis and analytical chemistry. Many of these applications of microfluidics are discussed elsewhere in this issue, and for the purposes of this Review we emphasize only a few salient points. First, there is now an extensive body of literature on how the physical properties of fluids that are available only on small spatial scales can be exploited for device functionality [5][6][7] . Many of these effects can also be used to control optical properties. Second, technological advances in device fabrication have made it possible to build miniaturized devices with complex networks of channels, valves, pumps and other methods of fluidic encapsulation and manipulation 8 . This creates a powerful set of tools for fluidic control, and because the feature sizes in these systems are shrinking over time, they will inevitably appro...

show abstract

Investigation of the dye concentration influence on the lasing wavelength and threshold for a micro-fluidic dye laser

Cited by 17 publications

References 4 publications

Fluidic fibre dye lasers

Fluidic fibre dye lasers

Laser Recording of Subcellular Neuron Activities

Developing optofluidic technology through the fusion of microfluidics and optics

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