Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy

Shao, Wencheng; Tang, Xiaobin; Bai, Yang; Shu, Diyun; Geng, Changran; Gong, Chunhui; Guan, Fada

doi:10.4103/jcrt.jcrt_1349_16

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…Apoint of contention is the proven dose perturbation effects of an MF on carbon ion and proton beams. Dosimetric studies have shown that there is dose distribution disruption at the air-tissue interface when an MF of 1.5 T is applied in photon beams, although its significance in carbon ion and proton beams is yet to be shown 8. On the contrary, another dosimetric study observed minimal changes in photon energy deposition even for an extremely strong MF of up to 70 T 16.…”

Section: Discussionmentioning

confidence: 99%

“…Inaniwa et al reported significantly reduced cell survival upon adding a longitudinal MF but interestingly not within a perpendicular MF 6,7. Furthermore, two other reports have shown a Bragg peak shift and dose perturbation upon employing an MF in proton beam radiotherapy;8,9 yet the biological effects of an MF have not been thoroughly evaluated and further research on possible interactions is warranted.…”

Section: Introductionmentioning

confidence: 99%

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Carbon ion and proton beam irradiation of a normal human TK6 lymphoblastoid cell line within a magnetic field of 1.0 tesla

Yudhistiara

Weber

et al. 2019

CMAR

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BackgroundConsidering the increasing simultaneous application of magnetic resonance imaging (MRI) for more precise photon radiotherapy, it will be likely for particle radiotherapy to adopt MRI for future image guiding. It will then be imperative to evaluate the potential biological effects of a magnetic field (MF) on particle irradiation. This study explores such effects on the highly radiosensitive TK6 lymphoblastoid human cell line.MethodsThe following three parameters were measured after irradiation with either carbon ion or proton beams using spread out Bragg peaks and applying different doses within a perpendicular 1.0 T MF: (1) cell survival fraction (14 days postirradiation), (2) treatment-specific apoptosis, which was determined through the measurement of population in the sub-G1 phase, and (3) cell cycle progression by means of flow cytometry. These were compared to the same parameters measured without an MF.ResultsThe clonogenic assay in both treatment groups showed almost identical survival curves with overlapping error bars. The calculated α values with and without an MF were 2.18 (σ=0.245) and 2.17 (σ=0.234) for carbon ions and 1.08 (σ=0.138) and 1.13 (σ=0.0679) for protons, respectively. Similarly, the treatment-specific apoptosis and cell cycle progression showed almost identical curves with overlapping error bars. A two-sample, unpooled t-test analysis was implemented for comparison of all mean values and showed p-values >0.05.ConclusionNo statistically significant difference in biological response of the TK6 cells was observed when they were irradiated using spreadout Bragg peaks within a perpendicular 1.0 T MF as compared to those, which received the same dose without the MF. This should serve as another supporting piece of evidence toward the implementation of MRI in particle radiotherapy, though further research is necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carbon ion and proton beam irradiation of a normal human TK6 lymphoblastoid cell line within a magnetic field of 1.0 tesla

Yudhistiara

Weber

et al. 2019

CMAR

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“… 35 Another similar prospective follow-up study found that long-term smoking more than 8 years was associated with increased risk of cervical intraepithelial neoplasia grade 3 or more. 36 …”

Section: Discussionmentioning

confidence: 99%

Determinants of VIA Positivity Among Women Screened for Cervical Precancerous Lesion in Public Hospitals of Oromia Region, Ethiopia: Unmatched Case-Control Study

Tekalegn

Aman

Woldeyohannes

et al. 2020

IJWH

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Purpose Globally, cervical cancer is the fourth most frequent cancer among women. An estimated 570,000 cases of cervical cancer representing 6.6% of all female cancers were reported in the year 2018. Approximately, 90% of deaths from cervical cancer occurred in low- and middle-income countries. Screening cervical cancer at an early stage and providing access to effective treatment can significantly improve the likelihood of survival. Hence, this study aimed to assess the determinants of visual inspection of cervix with acetic acid (VIA) positivity among women screened in public hospitals of Oromia region, Ethiopia. Methods A hospital-based un-matched case-control study was conducted in Oromia region, Ethiopia. Cases were women who have a positive result for the VIA test, and controls were women with a negative result. An interviewer-administered questionnaire was used to collect the data. Multiple binary logistic regressions were conducted to assess the determinants of VIA positivity. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were reported to describe the strength of associations. Statistical significance was declared at a p-value <0.05. Results A total of 74 cases and 148 controls were included in this study. The mean age of cases and controls was 40.5 ± 13.3 years and 37.1 ± 11.9 years, respectively. Women with parity of four or more children had two times higher odds being positive for VIA test compared to their counterparts (AOR: 2.1, 95% CI: 1.3–4.0). Women with a history of post-coital bleeding had three times higher odds of VIA positivity compared to their counterparts (AOR: 3.3, 95% CI: 1.2–8.0). History of sexually transmitted infection (AOR: 1.9, 95% CI: 1.1–3.5), having multiple sexual partners (AOR: 3.2, 95% CI: 1.2–8.0), and history of smoking (AOR: 8.9, 95% CI: 1.6–48.0) were also found to be determinants of VIA positivity. Conclusion This study found that women with parity greater than four children, post-coital bleeding, history of sexually transmitted infections, having multiple sexual partners, and history of smoking were significantly associated with VIA positivity. Women with the mentioned characteristics should be encouraged to have a close follow-up for the screening. Additionally, awareness creation activities on the identified risk factors are strongly recommended for all women.

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“…The link between smoking and cervical cancer has been well elucidated, with smoking influencing the incidence of CIN 3 and invasive cervical cancer [ 6 , 54 , 61 ]. This positive correlation is due to the direct mutagenic effect of nicotine (decomposed product of cigarettes) on the DNA in squamous cells.…”

Section: Epidemiology Of Cervical Cancermentioning

confidence: 99%

“…Benzo[ α ]pyrene, a constitute of tobacco, upregulates the amplification of the HPV genome, thus enhancing the integration of the viral genomes into the host’s genome [ 62 ]. The long-term effects of nicotine in vivo include the stimulation of the vascular endothelial growth factor, persistent cell proliferation, apoptosis inhibition, suppression of T lymphocyte activity and immunoglobulin levels and increased microvessel density [ 61 ].…”

Section: Epidemiology Of Cervical Cancermentioning

confidence: 99%

Cervical cancer: a meta-analysis, therapy and future of nanomedicine

Venkatas

Singh

2020

ecancer

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Cervical cancer is one of the leading causes of female death, with an annual mortality rate exceeding 200,000 in developing communities. Despite the past decade bearing witness to a reduction in cervical cancer cases throughout developed countries, the prevalence in developing countries continues to rapidly rise. The increase in cervical cancer cases is attributed to the lack of financial resources and the unavoidable risk factors of the disease. Traditional means of anticancer therapy are compromised by reduced drug potency, non-specificity, negative side effects and the development of multiple drug resistance (MDR), which leads to a decrease in the long-term anticancer therapeutic efficacy. Recent advances in nanomedicine have elucidated the potential of nanoparticles to reduce the side effects and improve the survival rate of patients, by enhancing selective delivery and uptake of photosensitive, therapeutic and genetic material to cervical cancer cells, thereby enhancing antitumour efficiency. This review paper analyses the risk factors and epidemiology of cervical cancer globally, especially in developing communities, whilst demonstrating the enhanced anticancer treatment using selected nanoparticles.

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Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy

Abstract: In MRI-guided cancer radiotherapy, the dose perturbation effects for therapeutic beams are relatively obvious, and the beam energies of therapeutic beams have large impacts on the magnetic-induced dose perturbations with the presence of a 1.5 T transverse magnetic field.

Cited by 8 publications

References 28 publications

<p>Carbon ion and proton beam irradiation of a normal human TK6 lymphoblastoid cell line within a magnetic field of 1.0 tesla</p>

<p>Carbon ion and proton beam irradiation of a normal human TK6 lymphoblastoid cell line within a magnetic field of 1.0 tesla</p>

<p>Determinants of VIA Positivity Among Women Screened for Cervical Precancerous Lesion in Public Hospitals of Oromia Region, Ethiopia: Unmatched Case-Control Study</p>

Cervical cancer: a meta-analysis, therapy and future of nanomedicine

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