Investigation of the biomechanical and histopathological effects of autologous conditioned serum on healing of Achilles tendon

Genç, Erdinç; Beytemür, Ozan; Yüksel, Serdar; Yılmaz, Eren; Çağlar, Aysel; Kucukyildirim, Bedri Onur; Güleç, Mehmet Akif

doi:10.1016/j.aott.2018.01.005

Cited by 17 publications

(12 citation statements)

References 23 publications

(28 reference statements)

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“…In three cases, there were two investigators [16,37,48] (Table 2). However, in eight studies, there were no data concerning the number of microscopic examiners [34,[38][39][40][50][51][52][53].…”

Section: Methodology Of Microscopic Investigationmentioning

confidence: 99%

“…Most of the collected studies included an assessment of the tendons' histopathology based on the classical Bonar score with four variables [1,16,34,36,[38][39][40][41][42][43][44][46][47][48][49][50][51][52][53]. However, a few authors aimed to modify the classical assumptions of the scoring system in order to improve the diagnostics and microscopic evaluation.…”

Section: The Bonar Score and Its Modificationsmentioning

confidence: 99%

“…Pingel et al, de Cesar et al, and Scott et al applied an additional variable based on the assessment of tenocyte proliferation [35,37,45]. Moreover, in six studies, the authors supported the histopathological evaluation with the Movin scoring system, which additionally includes the assessment of collagen fiber structure, decreased collagen stainability, hyalinization, and regional variations in cellularity [34,[38][39][40]43,47].…”

Section: The Bonar Score and Its Modificationsmentioning

confidence: 99%

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Therapeutic Advances in Tendinopathy Quantified Microscopically Using Bonar Score, with a Special Reference to PRP Therapy—A Systematic Review of Experimental Studies

et al. 2021

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(1) Background: The Bonar scoring system serves in the microscopic evaluation of tendon pathology. However, it can be easily adapted to investigate decreasing degeneration after treatment and quantify the healing progress. We believe that there is an actual need for a connection between clinical observations and tissue alterations arising during the treatment process, to gain superior functional outcomes. Herein, we perform a systematic review of the Bonar score’s application in the histopathological assessment of therapeutic advances in tendinopathy, with special reference to PRP therapy. (2) Methods: A systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The searching strategy was conducted across major databases: PubMed, Cochrane Central, ScienceDirect, SciELO, and Web of Science. The risk-of-bias assessment was made using the Cochrane Collaboration’s Risk of Bias Tool and SYRCLE. (3) Results: The searching strategy produced 807 articles, and after selection, 22 studies were included. We collected 21 animal studies (n = 472) and 1 human study (n = 45). Three types of tendons were taken into account: 14 Achilles tendons, 7 supraspinatus tendons (SST), and in 1 case, Achilles and patellar tendons simultaneously. A variety of therapeutic methods were used—from intra-tendinous substance injections to surgical procedures or mechanical stimuli—but platelet-rich plasma (PRP) therapy dominated among them and was present in six studies. Most of the collected studies included an assessment of the tendons’ histopathology based on the classical Bonar score (with four variables and one observer). The staining protocol was based on the hematoxylin and eosin technique. An evaluation of therapeutic effects showed 15 positive results, 6 negative results, and 1 neutral result of treatments. (4) Conclusions: To understand the tendinopathy phenomenon, a link between histopathology and clinical observations in chronic tendon disorders is required due to the possibility of functional outcome improvements. The Bonar scoring system is well established in tendon pathology assessment and could also be adopted to assess therapeutic results in tendon disorders. Studies that included the PRP application showed Bonar-scoring-system-based evidence of superior tendinous tissue healing related to improved clinical results.

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Section: Methodology Of Microscopic Investigationmentioning

confidence: 99%

Section: The Bonar Score and Its Modificationsmentioning

confidence: 99%

Section: The Bonar Score and Its Modificationsmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic Advances in Tendinopathy Quantified Microscopically Using Bonar Score, with a Special Reference to PRP Therapy—A Systematic Review of Experimental Studies

et al. 2021

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“…Evidence for histologic and mechanical collagen repair in Achilles injury model (183) and tendon healing in equine model (184).…”

Section: Laboratory Evidence For Tissue Regenerationmentioning

confidence: 99%

Neuroimmune modulation of pain and regenerative pain medicine

Buchheit¹,

Huh²,

Maixner³

et al. 2020

Journal of Clinical Investigation

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“…[1] Rupture of this tendon generally occurs in males aged between 30 and 50 years during workouts, and its incidence is approximately 18/10,000 individuals. [2,3] Rupture of the Achilles tendon can be treated through conservative methods. [4] One of the most controversial topics on tendon healing is undoubtedly related to Achilles tendon rupture.…”

mentioning

confidence: 99%