The effect of pentoxifylline on Achilles tendon healing in tenotomized rabbits

Şahin, Abdullah Alper; Özturan, Kutay Engin; Çıraklı, Alper; Yılmaz, Fahri; Boz, Mehmet; Kizilay, Hasan

doi:10.5606/ehc.2019.66859

Cited by 9 publications

(11 citation statements)

References 22 publications

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“…In some patients who are treated conservatively or surgically, there can be rerupture of tendons between 4 and 12 weeks after surgery, when the tissue quality is poor in the late stages of healing [ 10 ]. This is the reason that tendons in other studies and in the present study were evaluated at 4 and 6 weeks after surgery [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 94%

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

et al. 2021

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Background In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. Material/Methods In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Nine rabbits from each group were euthanized at week 4 and week 6 after surgery for histopathological and biomechanical testing. Results Granulation tissue formation was significantly greater in the experimental group in week 4 and week 6 than in the control group. Foreign body giant cell formation was significantly higher in the experimental group in week 4 and week 6. The maximum rupture force was significantly higher in the experimental group in week 4 and week 6 than in the control group. Elasticity and stiffness were comparable between groups in week 4; however, stiffness, but not elasticity, was significantly higher in the experimental group in week 6. Conclusions In the short term, cyanoacrylate enhanced tendon endurance in both a histopathological and biomechanical manner. We conclude that the early initiation of rehabilitation in patients may be safe in cases of cyanoacrylate use for surgical repair of tendon injury.

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Section: Methodsmentioning

confidence: 94%

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

et al. 2021

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“…In a study Şahin et al[ 26 ] investigated the effects of pentoxifylline on Achilles tendon healing in tenotomized rabbits. Pentoxifylline increased healing and strength in rabbit Achilles tendon by stimulating collagen synthesis, increasing vascularity and reducing inflammation, particularly in the early period both histopathologically and biomechanically.…”

Section: Discussionmentioning

confidence: 99%

Effects of L-carnitine on healing of Achilles tendon in rats

et al. 2022

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Objectives In this experimental study, we aimed to analyze the effects of levocarnitine (L-carnitine) on tendon healing after surgical repair of Achilles tendon rupture in a rat model. Materials and methods The study included 40 Wistar Albino rats divided into four groups: Group 1, neither surgical intervention nor substance applications were performed for the Achilles tendons. In the other groups, the right Achilles tendons were cut using a scalpel and repaired with a modified Kessler-type technique with 3/0 monofilament polydioxanone suture. In Group 2, the rats did not receive any additional treatment, except for surgical repair. In Group 3, the same volume similar to Group 4 of saline solution was administered intraperitoneally for seven days. In Group 4, each rat received 300 mg/kg of L-carnitine intraperitoneally for seven days. At Week 6, all rats were sacrificed. All right Achilles tendons were used for biomechanical tests and histopathological evaluations. Biochemical analysis of the matrix metalloproteinase was also performed using the blood specimens. Results There were no significant differences among the groups in terms of the histopathological parameters. Although the mean matrix metalloproteinase level was low in the L-carnitine group, it did not reach statistical significance. A significant increase in maximum force, tensile strength, and strength to 2-mm gap was observed in the L-carnitine group. Conclusion The significant effects of L-carnitine on biomechanical parameters may indicate favorable effects on Achilles tendon healing in rats by reducing matrix metalloproteinase 2 and 9. To improve Achilles tendon healing, further investigation for these markers is needed. Since the effects of L-carnitine on the Achilles tendon cannot be clearly distinguished histopathologically, further studies involving L-carnitine-induced effects are warranted.

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“…For this reason, there are many previous and ongoing experimental and clinical studies to minimize the complications that can be seen after tendon repair. [15,16] Many drugs and medical materials are used to prevent postoperative adhesion in tendon damage.…”

Section: Discussionmentioning

confidence: 99%

“…Many biomaterials and drugs have been tested in various studies to avoid complications such as adhesion and functional loss in tendon healing and to make the tendon stronger after the healing process is completed. [ 16 , 17 ] Growth factors and cytokines were used for this purpose and skeletal structures were created from cells containing fibroblasts and these factors and cytokines were exogenously applied. [ 18 ] In an experimental study published in 2011, intraperitoneal MB solution treatments were more effective according to vitamin E in preventing the formation of intra- abdominal adhesion in a rat uterine horn model.…”

Section: Discussionmentioning

confidence: 99%

Does methylene blue reduce adhesion during the healing process after tendon repair?

et al. 2020

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This study aims to biomechanically and histopathologically investigate the effects of methylene blue (MB) on preventing postoperative adhesion in chickens undergoing fullthickness flexor tendon incision. Materials and methods: This study was performed between June 2017 and June 2018 on Hubbard JA 57 type chickens (age, 6 months; weight, 2.2±0.3 kg). Sixty-four tendons were studied in 32 chickens, including 16 in the control group and 16 in the experimental group. The second and third finger flexor digitorum profundus tendons of the left foot of each chicken were repaired primarily after a full-thickness incision approximately 1 cm proximal to the distal adhesion area. In the control (n=32) and experimental groups (n=32), 0.25 mL of normal saline and 0.25 mL of 1% MB solutions were applied locally to the surgical site, respectively. The operated limb was immobilized using a circular cast. 16 chickens were randomly selected in each group and examined at the fourth week, and the remaining 16 chickens were examined at the sixth week. Thirty-two of these tendons were evaluated using the Tang histopathological adhesion classification system, and the other 32 were evaluated with a biomechanical pull system. Results: Adhesion was found to be less in the experimental group compared to the control group at the end of the fourth and sixth weeks both histopathologically and biomechanically. Furthermore, adhesion was significantly less in the experimental group at the end of the sixth week compared to the fourth week both histopathologically and biomechanically. Conclusion: Histopathological and biomechanical results show that MB, which has anti-inflammatory, antiseptic, antimicrobial and antioxidant effects, reduces adhesion during the healing process after tendon repair. We think that local MB application, particularly in surgeries performed after this type of injury, will be beneficial on early rehabilitation and functional results.

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The effect of pentoxifylline on Achilles tendon healing in tenotomized rabbits

Cited by 9 publications

References 22 publications

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

Effects of L-carnitine on healing of Achilles tendon in rats

Does methylene blue reduce adhesion during the healing process after tendon repair?

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