Investigation of the binding of roxatidine acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR spectroscopy

Maheshwari, Arti; Sharma, Manisha; Sharma, Deepak

doi:10.1016/j.carres.2011.07.003

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…Furthermore, there is a broad band in the 3200–3650 cm –1 area that can be attributed to the N–H or, to a lesser extent, O–H stretching vibrations (the latter might originate from the moisture or residually protonated carboxylate groups). , The presence of carboxylate groups coordinated to Co(II) centers is accounted for by the strong bands appearing at 1610 and 1654 cm –1 for antisymmetric stretching vibrations and a broad absorption occurring at 1378 cm –1 for the symmetric stretching vibration. Moreover, a C–O bending vibration contributes to the band at 1105 cm –1 . The FT-IR spectral features are in good agreement with the molecular structure of Co(II)-TMU-63 established by single-crystal X-ray diffraction.…”

Section: Resultsmentioning

confidence: 99%

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An Asymmetric Supercapacitor Based on a Non-Calcined 3D Pillared Cobalt(II) Metal–Organic Framework with Long Cyclic Stability

et al. 2019

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In this work, a new 3D metal–organic framework (MOF) {[Co3(μ4-tpa)3(μ-dapz)(DMF)2]·2DMF} n (Co(II)-TMU-63; H2tpa = terephthalic acid, dapz = pyrazine-2,5-diamine, DMF = dimethylformamide) containing low-cost and readily available ligands was generated, fully characterized, and used as an electrode material in supercapacitors without the need for a calcination process. Thus, the synthesis of this material represents an economical and cost-effective method in the energy field. The crystal structure of Co(II)-TMU-63 is assembled from two types of organic building blocks (μ4-tpa2– and μ-dapz ligands), which arrange the cobalt nodes into a complex layer-pillared net with an unreported 4,4,4,6T14 topology. The presence of open sites in this MOF is promising for studying electrochemical activity and other types of applications. In fact, Co(II)-TMU-63 as a novel electrode material when comparing with pristine MOFs shows great cycling stability, large capacity, and high energy density and so acts as an excellent supercapacitor (384 F g–1 at 6 A g–1). In addition, there was a stable cycling performance (90% capacitance) following 6000 cycles at 12 A g–1 current density. Also, the Co(II)-TMU-63//activated carbon (AC) asymmetric supercapacitor acted in a broad potential window of 1.7 V (0–1.7 V), exhibiting a high performance with 4.42 kW kg–1 power density (PD) and 24.13 Whkg–1 energy density (ED). These results show that the pristine MOFs have great potential toward improving different high-performance electrochemical energy storage devices, without requiring the pyrolysis or calcination stages. Hence, such materials are very promising for future advancement of the energy field.

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Section: Resultsmentioning

confidence: 99%

“…Moreover, a C−O bending vibration contributes to the band at 1105 cm −1 . 70 The FT-IR spectral features are in good agreement with the molecular structure of Co(II)-TMU-63 established by single-crystal X-ray diffraction.…”

Section: Resultsmentioning

confidence: 99%

An Asymmetric Supercapacitor Based on a Non-Calcined 3D Pillared Cobalt(II) Metal–Organic Framework with Long Cyclic Stability

et al. 2019

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“…By contrast, aromatic ring containing compounds ordinarily show binding constants an order of magnitude lower. 11,43 The lack of the cross-peaks of terminal methyl moiety of the gemini tail and βCD cavity provides indirect evidence that the drug may interact with βCDg, further indicating the biological benefit of the complexation. 15,16 The apparent lack of observable interactions between the drug and βCDg host indicates that a noninclusion ternary complex is formed.…”

Section: Molecular Pharmaceuticsmentioning

confidence: 99%

A ¹H NMR Study of Host/Guest Supramolecular Complexes of a Curcumin Analogue with β-Cyclodextrin and a β-Cyclodextrin-Conjugated Gemini Surfactant

et al. 2015

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Host systems based on β-cyclodextrin (βCD) were employed as pharmaceutical carriers to encapsulate a poorly soluble drug, curcumin analogue (NC 2067), in order to increase its water solubility. βCD was chemically conjugated with an amphiphilic gemini surfactant with the ability to self-assemble and to form nanoscale supramolecular structures. The conjugated molecule, βCDgemini surfactant (βCDg), was shown to be a promising drug delivery agent. In this report, its physicochemical properties were assessed in aqueous solution using 1D and 2D 1H NMR spectroscopy. The results showed that the apolar hydrocarbon domain of the gemini surfactant was self-included within the βCD internal cavity. The host/guest complexes composed of native βCD or βCDg with NC 2067 were examined using 1D/2D ROESY NMR methods. The stoichiometry of βCD/NC 2067 complex was estimated using Job's method via 1H NMR spectroscopy. The binding geometry of NC 2067 within βCD was proposed using molecular docking and further supported by 1D and 2D ROESY NMR results. Addition of NC 2067 to βCDg revealed minimal changes to the overall structure of the βCDg system, in agreement with the formation of a βCDg/NC 2067 ternary complex.

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“…The peak around 1655 cm −1 is attributed to the O–H bending vibration of adsorbed water and hydroxyl groups in β -CD molecule. The absorption peak around 1033 cm −1 is stretching vibration of C–O–C and C–O bonds in the hole 28 43 44 45 . Moreover, new weak distinct peaks appeared around 1255 cm −1 and 3700 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

Cyclodextrin-Based Metal-Organic Nanotube as Fluorescent Probe for Selective Turn-On Detection of Hydrogen Sulfide in Living Cells Based on H2S-Involved Coordination Mechanism

Xin

Wang

Gong

et al. 2016

Sci Rep

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Hydrogen sulfide (H2S) has been considered as the third biologically gaseous messenger (gasotransmitter) after nitric oxide (NO) and carbon monoxide (CO). Fluorescent detection of H2S in living cells is very important to human health because it has been found that the abnormal levels of H2S in human body can cause Alzheimer’s disease, cancers and diabetes. Herein, we develop a cyclodextrin-based metal-organic nanotube, CD-MONT-2, possessing a {Pb14} metallamacrocycle for efficient detection of H2S. CD-MONT-2′ (the guest-free form of CD-MONT-2) exhibits turn-on detection of H2S with high selectivity and moderate sensitivity when the material was dissolved in DMSO solution. Significantly, CD-MONT-2′ can act as a fluorescent turn-on probe for highly selective detection of H2S in living cells. The sensing mechanism in the present work is based on the coordination of H2S as the auxochromic group to the central Pb(II) ion to enhance the fluorescence intensity, which is studied for the first time.

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Investigation of the binding of roxatidine acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR spectroscopy

Cited by 12 publications

References 12 publications

An Asymmetric Supercapacitor Based on a Non-Calcined 3D Pillared Cobalt(II) Metal–Organic Framework with Long Cyclic Stability

An Asymmetric Supercapacitor Based on a Non-Calcined 3D Pillared Cobalt(II) Metal–Organic Framework with Long Cyclic Stability

A ¹H NMR Study of Host/Guest Supramolecular Complexes of a Curcumin Analogue with β-Cyclodextrin and a β-Cyclodextrin-Conjugated Gemini Surfactant

Cyclodextrin-Based Metal-Organic Nanotube as Fluorescent Probe for Selective Turn-On Detection of Hydrogen Sulfide in Living Cells Based on H2S-Involved Coordination Mechanism

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Investigation of the binding of roxatidine acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR spectroscopy

Cited by 12 publications

References 12 publications

An Asymmetric Supercapacitor Based on a Non-Calcined 3D Pillared Cobalt(II) Metal–Organic Framework with Long Cyclic Stability

An Asymmetric Supercapacitor Based on a Non-Calcined 3D Pillared Cobalt(II) Metal–Organic Framework with Long Cyclic Stability

A 1H NMR Study of Host/Guest Supramolecular Complexes of a Curcumin Analogue with β-Cyclodextrin and a β-Cyclodextrin-Conjugated Gemini Surfactant

Cyclodextrin-Based Metal-Organic Nanotube as Fluorescent Probe for Selective Turn-On Detection of Hydrogen Sulfide in Living Cells Based on H2S-Involved Coordination Mechanism

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A ¹H NMR Study of Host/Guest Supramolecular Complexes of a Curcumin Analogue with β-Cyclodextrin and a β-Cyclodextrin-Conjugated Gemini Surfactant