Investigation of the Association of Serum Trace Elements Concentrations and Serum Biochemical Parameters with the Risk of Polycystic Ovary Syndrome: a Case–Control Study

Sharma, Priya; Kapoor, Harmanpreet Singh; Kaur, Balpreet; Kamra, Pooja; Khetarpal, Preeti

doi:10.1007/s12011-023-03664-6

Cited by 7 publications

(6 citation statements)

References 54 publications

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“…De ciency of selenium have been found to be signi cantly associated with PCOS risk in previous observational studies and meta-analysis [14][15][16]. Recently, we have also reported Se de ciency and its association with PCOS in north India population [17]. We further report the signi cant frequency of genetic variants involved in Se availability and Se-response in the study population and evaluate their functional impact through in-silico analysis.…”

Section: Introductionmentioning

confidence: 75%

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Sharma,

Khetarpal

2024

Biol Trace Elem Res

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Selenium is a trace element and its de ciency has been associated with the risk of PCOS, a multifactorial syndrome that affects a large number of women worldwide. Several databases and literature were searched to nd out genetic variants of the genes involved in selenium uptake, metabolism and regulation which may be signi cantly associated with risk of PCOS through Se related pathways. Genes whish require selenium for their biological actions to perform were also shortlisted. A total of eighteen signi cantly associated genes were identi ed which were shortlisted among forty-four variants that could play potential role in the PCOS risk among the study population. The genetic variant distribution data was available in-house and was obtained through GWAS study of the North India population. In silico tools were applied to understand the functional impact of these variants. Three variants namely LDLR(rs2228671), TNF (rs1041981), and SAA2 (rs2468844) are strongly associated with PCOS risk and have a functional impact on encoded protein. Certain variants of Se uptake genes such as DIO1, GPX2, TXNRD1, DIO2 GPX3 genes signi cantly increase or decrease risk of PCOS development. Se transporter gene SELENOP polymorphism rs9686343 with C allele signi cantly increased PCOS risk. Other potential genes that require selenium for their biological actions are involved in the in ammatory, antioxidant response, and energy homeostasis signaling pathways. Thus genetic variants of the population may affect the Se availability or Se de ciency may modulate the effect of Se-associated genes due to genetic polymorphism. This information may be helpful in dosage adjustment of Se supplementation for a population in order to have maximum bene ts.

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Section: Introductionmentioning

confidence: 75%

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Sharma,

Khetarpal

2024

Biol Trace Elem Res

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“…Furthermore, Kinnamon reported competition between Cu and Zn in the fetus and placenta, indicating the importance of optimizing the ratio of these elements during pregnancy to enhance reproductive outcomes ( 48 ). Interestingly, another case–control study conducted by Priya et al demonstrated potential interactions between Fe and Cu in the case of polycystic ovary syndrome ( 49 ). Andersen et al proposed that Cu deficiency not only affected the concentration of Fe but also indirectly impacted Fe transporters, which affected the delivery of Fe to the fetus ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Individual and combined association between nutritional trace metals and the risk of preterm birth in a recurrent pregnancy loss cohort

Liu,

Wang,

et al. 2023

Front. Nutr.

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BackgroundRecurrent pregnancy loss (RPL) was associated with an elevated risk of pregnancy complications, particularly preterm birth (PTB). However, the risk factors associated with PTB in RPL remained unclear. Emerging evidence indicated that maternal exposure to metals played a crucial role in the development of PTB. The objective of our study was to investigate the individual and combined associations of nutritional trace metals (NTMs) during pregnancy with PTB in RPL.MethodsUsing data from a recurrent pregnancy loss cohort (n = 459), propensity score matching (1:3) was performed to control for covariates. Multiple logistic regression and multiple linear regression were employed to identify the individual effects, while elastic-net regularization (ENET) and Bayesian kernel machine regression (BKMR) were used to examine the combined effects on PTB in RPL.ResultsThe logistic regression model found that maternal exposure to copper (Cu) (quantile 4 [Q4] vs. quantile 1 [Q1], odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.05, 0.74) and zinc (Zn) (Q4 vs. Q1, OR: 0.19, 95%CI: 0.04, 0.77) was inversely associated with total PTB risk. We further constructed environmental risk scores (ERSs) using principal components and interaction terms derived from the ENET model to predict PTB accurately (p < 0.001). In the BKMR model, we confirmed that Cu was the most significant component (PIP = 0.85). When other metals were fixed at the 25th and 50th percentiles, Cu was inversely associated with PTB. In addition, we demonstrated the non-linear relationships of Zn with PTB and the potential interaction between Cu and other metals, including Zn, Ca, and Fe.ConclusionIn conclusion, our study highlighted the significance of maternal exposure to NTMs in RPL and its association with PTB risk. Cu and Zn were inversely associated with PTB risk, with Cu identified as a crucial factor. Potential interactions between Cu and other metals (Zn, Ca, and Fe) further contributed to the understanding of PTB etiology in RPL. These findings suggest opportunities for personalized care and preventive interventions to optimize maternal and infant health outcomes.

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“…Disruptions in these hormonal harmonies, as seen in conditions like PCOS, can spell challenges for fertility [165][166][167][168][169][170][171][172][173][174][175]. Through these mechanisms, adequate magnesium levels contribute to optimizing insulin sensitivity and stabilizing glucose metabolism.…”

Section: Magnesiummentioning

confidence: 99%

“…Through these mechanisms, adequate magnesium levels contribute to optimizing insulin sensitivity and stabilizing glucose metabolism. Research indicates that women with PCOS often exhibit lower serum magnesium levels compared to those without the condition [165][166][167][168][169][170][171]173,174]. Consequently, magnesium supplementation may represent a promising therapeutic avenue for PCOS patients to ameliorate insulin metabolism and reduce the risk of associated comorbidities [161,[176][177][178][179][180].…”

Section: Magnesiummentioning

confidence: 99%

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

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The role of minerals in female fertility, particularly in relation to the menstrual cycle, presents a complex area of study that underscores the interplay between nutrition and reproductive health. This narrative review aims to elucidate the impacts of minerals on key aspects of the reproductive system: hormonal regulation, ovarian function and ovulation, endometrial health, and oxidative stress. Despite the attention given to specific micronutrients in relation to reproductive disorders, there is a noticeable absence of a comprehensive review focusing on the impact of minerals throughout the menstrual cycle on female fertility. This narrative review aims to address this gap by examining the influence of minerals on reproductive health. Each mineral’s contribution is explored in detail to provide a clearer picture of its importance in supporting female fertility. This comprehensive analysis not only enhances our knowledge of reproductive health but also offers clinicians valuable insights into potential therapeutic strategies and the recommended intake of minerals to promote female reproductive well-being, considering the menstrual cycle. This review stands as the first to offer such a detailed examination of minerals in the context of the menstrual cycle, aiming to elevate the understanding of their critical role in female fertility and reproductive health.

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Investigation of the Association of Serum Trace Elements Concentrations and Serum Biochemical Parameters with the Risk of Polycystic Ovary Syndrome: a Case–Control Study

Cited by 7 publications

References 54 publications

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Individual and combined association between nutritional trace metals and the risk of preterm birth in a recurrent pregnancy loss cohort

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

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