Investigation of the antimycobacterial activity of 36 plant extracts from the brazilian Atlantic Forest

Ramos, Daniela Fernandes; Leitão, Gilda Guimarães; Costa, Fernanda das Neves; Abreu, Lisandra Ferreira de; Villarreal, Javier Vargas; Leitão, Suzana Guimarães; Fernández, Salvador Luis Said y; Silva, Pedro Eduardo Almeida da

doi:10.1590/s1516-93322008000400013

Cited by 23 publications

(19 citation statements)

References 23 publications

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“…Considering that the cumarú positive sample was a crude Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity Danilo R. Oliveira et al ethanolic extract, this result becomes very promising for the identification of bioactive substances. Aspidosperma rigidum and Aspidosperma excelsum, known as carapanaúba, are rich in indole alkaloids (Vieira et al 2010) and antimycobacterial activity has already been recently demonstrated for several substances of this class (Copp, 2003;Okunade et al, 2004), as well as for other species of the Apocynaceae family (Case et al, 2006;Gautam et al, 2007;Ramos et al, 2008;Mohamad et al, 2011). Some species such as Allium cepa, Anacardium occidentale, Cynnamomum zeylanicum, Jatropha curcas, Psidium guajava and Zingiber officinale in Malaysian (Mohamad et al, 2011), besides Chenopodium ambrosioides, Ruta graveolens, Ocimum americanum, Allium sativum and Mangifera indica in Índia (Gautam et al, 2007) are also indicated as a possible source of new antimycobacterial agents, and in South Africa, Ruta graveolens has also highlighted its potential (McGaw et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…Medicinal plants have attracted great interest as a source for finding new efficient drugs or prototypes to TB treatment, and the literature is covered with many examples of plant selection methods based on random or ethnopharmacological approaches (Cantrell et al, 1998;Newton et al, 2002;Leitão et al, 2006;Gautam et al, 2007;McGaw et al, 2008;Ramos et al, 2008;Mohamad et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity

Oliveira¹,

Leitão²,

Coelho³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The municipality of Oriximiná, Brazil, has 33 quilombola communities in remote areas, endowed with wide experience in the use of medicinal plants. An ethnobotanical survey was carried out in five of these communities. A free-listing method directed for the survey of species locally indicated against Tuberculosis and lung problems was also applied. Data were analyzed by quantitative techniques: saliency index and major use agreement. Thirty four informants related 254 ethnospecies. Among these, 43 were surveyed for possible antimycobacterial activity. As a result of those informations, ten species obtained from the ethnodirected approach (ETHNO) and eighteen species obtained from the random approach (RANDOM) were assayed against Mycobacterium tuberculosis by the microdilution method, using resazurin as an indicator of cell viability. The best results for antimycobacterial activity were obtained of some plants selected by the ethnopharmacological approach (50% ETHNO x 16,7% RANDOM). These results can be even more significant if we consider that the therapeutic success obtained among the quilombola practice is complex, being the use of some plants acting as fortifying agents, depurative, vomitory, purgative and bitter remedy, especially to infectious diseases, of great importance to the communities in the curing or recovering of health as a whole.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity

Oliveira¹,

Leitão²,

Coelho³

et al. 2011

Rev. bras. farmacogn.

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“…Esses resultados já foram identificados em outros estudos com extratos de D. macrophylla e D. hirsuta, inclusive frente a cepas resistentes. 10,27,35,36 Além disso, outros autores tem proposto um amplo espectro de atividade antimicrobiana (antifúngica e antibacteriana) de extratos de partes aéreas de plantas da família Rubiaceae. 6,37 Os extratos de D. saccifera apresentaram valores de CMI semelhantes tanto nas atividades antimicobacterianas quanto antifúngicas, porém, apenas os extratos diclorometânico e metanólico das folhas e diclorometânico dos galhos apresentaram atividade frente às cepas de M. tuberculosis testadas.…”

Section: -32unclassified

“…6,37,38 A presença de alcalóides e terpenóides, comumente relatada em plantas da família Rubiaceae poderia explicar a atividade e o amplo espectro de ação dos extratos de D. macrophylla e D. saccifera encontrados neste estudo. 1,19,36 Os resultados da presente pesquisa permitem identificar um amplo espectro de ação destes extratos tanto para as espécies de Candida sp. quanto para as espécies micobacteriana avaliadas.…”

Section: -32unclassified

Avaliação das atividades antifúngica, antimicobacteriana e larvicida de Duroia macrophylla e D. saccifera

Reis

Carrion

Rodrigues

et al. 2016

Rev Epidemiol Control Infect

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RESUMO Justificativa e objetivos:A vasta biodiversidade amazônica tem sido apontada como uma fonte de produtos naturais candidatos a diversas atividades farmacológicas, principalmente no combate a doenças infecciosas. Algumas espécies, tais como as pertencentes ao gênero Duroia, da família Rubiaceae, têm sido caracterizadas pela produção de metabólitos secundários com propriedades biológicas importantes, porém são escassos os estudos com espécies deste gênero. Desta forma, o objetivo deste estudo foi avaliar a atividade antimicobacteriana, antifúngica e antiparasitária de extratos de D. macrophylla e D. saccifera. Métodos: Foram coletados materiais vegetais de D. macrophylla e D. saccifera na Reserva Florestal A. Ducke em Manaus-AM, a partir dos quais foram preparados extratos diclorometânico, metanólico e aquoso e determinada a concentração inibitória e concentração larvicida mínima. Resultados: No que diz respeito aos extratos de D. saccifera¸ o extrato diclorometânico dos galhos foi o mais ativo frente às espécies fúngicas e as cepas micobacterianas avaliadas. Por outro lado, o extrato metanólico e o diclorometânico das folhas de D. macrophylla, foram os mais ativos frente a Candida sp. e Mycobacterium tuberculosis, respectivamente, porém, nenhum dos seis extratos avaliados apresentaram atividade antiparasitária frente a Toxocara canis. Conclusão: Esses resultados demonstram as propriedades antimicrobianas dessas plantas amazônicas para o desenvolvimento de novas alternativas terapêuticas no tratamento de doenças infecciosas, tais como a tuberculose e candidíase. DESCRITORES: Candida. Rubiaceae. Mycobacterium tuberculosis. Toxocara canis. ABSTRACT Bachground and objective:The wide Amazonian biodiversity has been identified as a source of natural product candidates to various pharmacological activities, particularly in combating infectious diseases. Some species, such as the genus Duroia, belonging to the Rubiaceae family, has been characterized by the production of secondary metabolites with important biological properties, but there are few studies with species of this genus. Thus, the objective of this study was to evaluate the antimycobacterial, antifungal and antiparasitic activity of D. macrophylla and D. saccifera extracts by determining the minimum inhibitory concentration and minimum larvicide concentration. Methods: Were collected plant materials of the D. macrophylla and D. saccifera in Forest Reserve A. Ducke in Manaus AM, from which were prepared dichloromethane, methanol and aqueous extracts and determined the minimum inhibitory concentration and larvicidal concentration. Results: With regard to D. saccifera¸ extracts the dichloromethane extract of the branches was the most active against the fungal species and mycobacterial strains evaluated. On the other hand, the methanol and dichloromethane extract of the D. macrophylla leaves, were most active against Candida sp. and Mycobacterium tuberculosis, respectively, but none of the six evaluated extracts showed antiparasitic activity against Toxocar...

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“…The species Cariniana brasiliensis was described as skin-lightening cosmetic by the inhibition of hyaluronidase and it also showed anti-tyrosinase activity (Baurin, Arnoult, Scior, & Bernard, 2002), whilst the extract of Cariniana estrellensis was described as active against Mycobacterium kansasii (Ramos et al, 2008). Three triterpenoidal saponins were isolated from the stem bark of C. rubra Gardner & Miers, whereas some constituents have been isolated from other species of this family, including pentacyclic triterpenes, saponins, ellagic acid and indol-quinazoline alkaloids (Carvalho, Velandia, Oliveira, & Bezerra, 1998;Lima, Filho, & Batisda, 2002).…”

Section: Introductionmentioning

confidence: 99%

Isolation and chromatographic analysis of bioactive triterpenoids from the bark extract ofCariniana domestica(Mart) Miers

Janovik

Boligon

Frohlich

et al. 2012

Natural Product Research

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The Lecythidaceae family is composed of 25 genera and 400 species that occur in the form of trees with a pantropical distribution. The genera Cariniana belongs to the family Lecythidaceae, and there are few reports considering these species. In this work, fractionation of the dichloromethane fraction obtained from the aqueous extract of the stem bark of Cariniana domestica (Mart) Miers, popularly known as Jequitibá-roxo, led to the isolation of two mixtures of triterpenoids: lupeol and β-amyrin and β-sitosterol and stigmasterol. The structures of the isolated compounds were elucidated by spectroscopic (NMR) and chromatographic (GC-MS) techniques as well as literature data comparisons. β-Sitosterol, stigmasterol, lupeol and β-amyrin were quantified in dichloromethane fraction by high-performance liquid chromatography (HPLC/DAD). The dichloromethane fraction was also investigated for antioxidant and antifungal activities. The isolated compounds and their biological activities are reported for the first time for the species C. domestica.

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Investigation of the antimycobacterial activity of 36 plant extracts from the brazilian Atlantic Forest

Cited by 23 publications

References 23 publications

Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity

Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity

Avaliação das atividades antifúngica, antimicobacteriana e larvicida de Duroia macrophylla e D. saccifera

Isolation and chromatographic analysis of bioactive triterpenoids from the bark extract ofCariniana domestica(Mart) Miers

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