Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Nam, Sohee; Ji, Xu; Park, Jong-Sang

doi:10.5012/bkcs.2011.32.3.956

Cited by 41 publications

(11 citation statements)

References 21 publications

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“…However, in the case of non-particle form of the formulations as a control, such a long-term storage effect or such a deep penetration into the hair follicles behavior cannot be observed. In the present study, penetration of NLCs through guinea pig skin was twice or threefold higher than NE and oil solution, which was consistent with previous observation (25,28). This is partly associated with peculiar property of the nanoparticles, which can penetrate excellently into the hair follicles, reaching deeper functional structures and can be stored there for a long time (26).…”

Section: Ex Vivo Skin Penetration Studiessupporting

confidence: 79%

Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone

2012

AAPS PharmSciTech

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Abstract. Idebenone (IDB) is a synthetic antioxidant and analog of coenzyme Q10. The percutaneous permeation of IDB was investigated in guinea pig skin after application of different formulations. The enhancing effects of various formulations [nanostructured lipid carriers (NLCs), nanoemulsion (NE), or oil solution] on the permeation of IDB were evaluated using ex vivo guinea pig skins. Furthermore, stability of different formulations and in which chemical stability of IDB was determined during storage. Permeation experiments revealed that formulations varied in their ability to enhance the skin permeation of IDB. For NLC formulation, the cumulative amount of IDB in the epidermis, dermis, and acceptor medium of diffusion cells was approximately threefold more than NE or oil solution at the end of 24-h experiment. No significant difference between NE and oil solution was observed in the enhancement of penetration efficacy of IDB. Different formulations resulted in stability with different properties. NLC formulation revealed preferentially more stable than NE. The residual percentage of IDB loaded in NLCs, NE, and oil solution was 90.1%, 65.4%, and 51.3%, respectively, when stored at 40°C under 75% RH and 3,000 lx light conditions for 180 days. The results obtained here demonstrated that the abilities of NLCs to improve the chemical stability of IDB and enhance the skin permeation are much better than NE and oil solution. These suggest that NLCs containing IDB have significant potential use for skin care as an alternative topical formulation.

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Section: Ex Vivo Skin Penetration Studiessupporting

confidence: 79%

Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone

2012

AAPS PharmSciTech

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“…The amount of drug entrapped in the nanoparticle was calculated by dissolving the freeze-dried NP in methanol and sonicated for 20 min [ 19 ]. The solution was filtered, and the filtrate was used to analyze the amount of drug entrapped.…”

Section: Methodsmentioning

confidence: 99%

Highly Stable PEGylated Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for the Effective Delivery of Docetaxel in Prostate Cancers

2016

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In the present study, a highly stable luteinizing-hormone-releasing hormone (LHRH)-conjugated PEGylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles were developed for the successful treatment of prostate cancers. We have demonstrated that a unique combination of targeted drug delivery and controlled drug release is effective against prostate cancer therapy. The docetaxel (DTX)/PLGA-LHRH micelles possessed a uniform spherical shape with an average diameter of ~170 nm. The micelles exhibited a controlled drug release for up to 96 h which can minimize the non-specific systemic spread of toxic drugs during circulation while maximizing the efficiency of tumor-targeted drug delivery. The LHRH-conjugated micelles showed enhanced cellular uptake and exhibited significantly higher cytotoxicity against LNCaP cancer cells. We have showed that PLGA-LHRH induced greater caspase-3 activity indicating its superior apoptosis potential. Consistently, LHRH-conjugated micelles induced threefold and twofold higher G2/M phase arrest than compared to free DTX or PLGA NP-treated groups. Overall, results indicate that use of LHRH-conjugated nanocarriers may potentially be an effective nanocarrier to effectively treat prostate cancer.

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“…The differential scanning calorimetry (DSC) is used to determine the physical and energetic properties of a substance as a function of temperature. The X-ray diffractometer was developed to measure the geometric scattering radiation from crystal planes within nanoparticle dispersion for assessing the degree of crystallinity using wide-angle X-ray diffraction (WXRD) [33,34].…”

Section: Characterization Of Nanostructured Lipid Carriersmentioning

confidence: 99%

The Role of Natural Dietary Products in Nanomedicine

Rahman¹,

Othman²,

RasedeeAbdullah³

et al. 2019

Nanomedicines

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It has long been established that a diet rich in fresh fruits, vegetables, seeds, grains and legumes and antioxidants, and other beneficial compounds may help prevent various human diseases. However, diet is not a cure for treatment of severe diseases, but it may help prevent some ailments, and it can help the body overcome the effects of conventional treatments. Natural compounds not only serve as a drug or template for drugs but also, in many instances, had been a source of discovery of novel biology that provided better understanding of target and pathway involved in the disease processes. In addition, drugs derived from natural compounds work better for patients than do drugs manufactured synthetically. Approximately, 40% of drugs in the pipeline and 70% of synthetic therapeutic molecules are plagued with poor solubility, oral bioavailability, and delivery. Drugs with poor solubility encounter limited transport during oral administration because of low concentration gradient between the gut and the blood vessels. To increase body fluid saturation solubility of poorly soluble drug, new delivery methods need to be developed using natural dietary plant metabolites.

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Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Cited by 41 publications

References 21 publications

Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone

Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone

Highly Stable PEGylated Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for the Effective Delivery of Docetaxel in Prostate Cancers

The Role of Natural Dietary Products in Nanomedicine

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