Investigation of sustained release mucoadhesive in-situ gel system of Secnidazole for the persistent treatment of vaginal infections

Karthick, R.; Devi, D. Ramya; Hari, B.N. Vedha

doi:10.1016/j.jddst.2017.11.001

Cited by 14 publications

(4 citation statements)

References 18 publications

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“…For the DHRL0 formula, the value of n was obtained at 0.702, showing a non-Fickian diffusion mechanism. The release mechanism from this rosin-based in situ forming gel formulation was influenced by diffusion and erosion [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Khaing

Mahadlek

Okonogi

et al. 2022

Gels

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Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is an effective periodontitis treatment. The aqueous insoluble property of rosin is suitable for preparing a solvent exchange-induced in situ forming gel. This study aims to investigate the role of incorporating lime peel oil (LO) on the physicochemical properties of injectable in situ forming gels based on rosin loaded with 5% w/w doxycycline hyclate (DH) in dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone (NMP). Their gel formation, viscosity, injectability, mechanical properties, wettability, drug release, and antimicrobial activities were evaluated. The presence of LO slowed gel formation due to the loose precipitate formation of gel with a high LO content. The viscosity and injectability were slightly increased with higher LO content for the DH-loaded rosin-based in situ forming gel. The addition of 10% LO lowered gel hardness with higher adhesion. LO incorporation promoted a higher drug release pattern than the no oil-added formulation over 10 days and the gel formation rate related to burst drug release. The drug release kinetics followed the non-Fickian diffusion mechanism for oil-added formulations. LO exhibited high antimicrobial activity against Porphyromonas gingivalis and Staphylococcus aureus. The DH-loaded rosin in situ forming gel with an addition of LO (0, 2.5, 5, and 10% w/w) inhibited all tested microorganisms. Adding 10% LO to rosin-based in situ forming gel improved the antimicrobial activities, especially for the P. gingivalis and S. aureus. As a result, the study demonstrates the possibility of using an LO amount of less than 10% loading into a rosin-based in situ forming gel for efficient periodontitis treatment.

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Section: Resultsmentioning

confidence: 99%

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Khaing

Mahadlek

Okonogi

et al. 2022

Gels

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“…Differences in parameters from formulations were statistically analyzed by one-way analysis of variance (ANOVA) at a 95 % confidence interval. Statistically significant differences were defined as p<0.05 [28] .…”

Section: Discussionmentioning

confidence: 99%

An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

Salman¹,

Alhamdany²,

Yousif³

2020

pharmaceutical-sciences

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“…In terms of physical properties, this polymer is highly mucoadhesive, which makes it a very good choice for being used in topical applications to mucous membranes as it increases the contact time of the drug with the mucosal membrane [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Attenuation Coefficients of Epoxy Resin with Carbopol Polymer as a Breast Phantom Material at Low Photon Energy Range

Marashdeh

Abdulkarim

2023

Polymers

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Six different composites of epoxy resin and Carbopol 974p polymer were prepared based on Carbopol 974p polymer concentrations of 0%, 5%, 10%, 15%, 20%, and 25%. The linear and mass attenuation coefficients, Half Value Layer (HVL), and mean free path (MFP) of these composites were determined using single-beam photon transmission in the energy range between 16.65 keV and 25.21 keV. This was carried out by determining the attenuation of ka1 X-ray fluorescent (XRF) photons from niobium, molybdenum, palladium, silver, and tin targets. The results were compared with theoretical values of three types of breast material (Breast 1, Breast 2, Breast 3) and Perspex, which was calculated using a XCOM computer program. The results show that there were no significant differences in the attenuation coefficient values after the consequent Carbopol additions. Moreover, it was found that the mass attenuation coefficients of all tested composites were close to those of Perspex and the values for Breast 3. The HVL and MFP results showed that the E25 sample is closer to the results of the Perspex material with differences of (0.53–1.15%) and (0.51–1.20%), respectively. In addition, the densities of the fabricated samples were in the range of 1.102–1.170 g/cm3, which is in the range of human breast density. A computed tomography (CT) scanner was used to investigate the CT number values for the fabricated samples. The CT numbers of all samples were in the range of human breast tissue (24.53–40.28 HU). Based on these findings, the fabricated epoxy–Carbopol polymer is a good candidate for use as a breast phantom material.

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Investigation of sustained release mucoadhesive in-situ gel system of Secnidazole for the persistent treatment of vaginal infections

Cited by 14 publications

References 18 publications

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

Determination of the Attenuation Coefficients of Epoxy Resin with Carbopol Polymer as a Breast Phantom Material at Low Photon Energy Range

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