An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

Salman, Zeina D; Alhamdany, Anas Tarik; Yousif, Nora Zawar

doi:10.36468/pharmaceutical-sciences.691

Cited by 3 publications

(1 citation statement)

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“…We assume that the decrease in the percentage of API release in samples 1 and 3 (Fig. 2) is associated with incorrect inclusion of diosmin and hesperidin in the formed sodium alginate-calcium stearate complex [33]. According to the results of the study of literary sources, this can be observed with excessive addition of the APIs to the biphasic medium (sample 3 for 4.0 mass suppositories had 500 mg of API) or formation of excessively strong alginate-calcium complex with active substances [34].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive study for the development of rectal suppositories with diosmin and hesperidin

Борко

Kovalevska

Grudko

et al. 2022

SR: PS

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The aim. To conduct a comprehensive study of biphasic-type suppositories that contain diosmin and hesperidin. Materials and methods. Samples of biphasic-type suppositories with a mass of 4.0 were objects of the study. Pharmacological, technological and analytical research methods were used to directly or indirectly analyze the strength and completeness of the drug activity. Thus, in this work we combined the study of the specificity of the pharmacological action of the drug, experimental verification of the quantitative content of API, analysis of the structural properties of suppositories and study of the profile of the release of active pharmaceutical ingredients. Results. Therefore, based on the obtained data, the most effective dose was 75 mg / kg (in terms of a human dose of 300 mg per suppository). The drug in the selected dose showed a significant therapeutic effect, which significantly exceeded that of the test sample at a lower dose and the reference agent. According to the results of technological studies, it was determined that all samples of suppositories had satisfactory structural and mechanical properties. Studies of the histological structure of the mucous membrane of rats proved that there is a positive effect of treatment with suppositories with diosmin and hesperidin due to the improvement of the normal condition of the mucous membrane, the absence of edema and ulcerative defect. Research of the release profile of active pharmaceutical ingredients showed that the best percentage of release is characteristic of sample 2 (99.8 %) Conclusions. Therefore, suppositories with diosmin and hesperidin in therapeutically dose of 75 mg/kg of animal weight can be used for further research and will be of interest in the treatment of hemorrhoids of both acute and chronic forms

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Section: Discussionmentioning

confidence: 99%