Investigation of surface-modified solid lipid nanocontainers formulated with a heterolipid-templated homolipid

Evaluation of Gentamicin-Entrapped Solid Lipid Microparticles Formulated with a Biodegradable Homolipid from <i>Capra hircus</i>

“…The rapid release of gentamicin from the SLMs was possibly due to a burst effect caused by the leaching out of the unentrapped drug adhering to the surface of the SLMs after the initial rapid hydration and swelling. Burst release resulting in biphasic release pattern may be utilized in dosage form design [15][16][17]. Perhaps, there was a lot of peripheral attachment of the drug as a result of expulsion or drug migration due to solvent drag during lyophilization.…”

“…By tactical engineering of lipid drug delivery systems (LBDDS) such as solidified reverse micellar solution-based solid lipid microparticles (SRMSbased SLMs), these problems could be surmounted. Researchers have used this novel technology to increase the overall efficacy while minimizing toxicity of gentamicin [4,5,[12][13][14][15][16][17]. Homolipids and heterolipids have gained renewed interests as excipients for LBDDS [15].…”

Phospholipon 90H (P90H)–based PEGylated microscopic lipospheres delivery system for gentamicin: an antibiotic evaluation

“…The drug solubility and miscibility in melted lipid, chemical and physical structure of lipid materials, and their polymorphic state determine the loading capacity of drug in the lipid particles [4][5][6][7] . The amount of drug encapsulated can vary from 1 % to 5 % for hydrophilic compounds and up to 80 % for lipophilic compounds [8,9] .…”

Formulation development and evaluation of the anti-malaria properties of sustained release artesunate-loaded solid lipid microparticles based on phytolipids

“…The minor increase in the enthalpy suggested that the lipid matrices generated imperfect matrices due to distortion of crystal arrangement of dika wax after melting and solidification (Sanna et al, 2004;Jaspart et al, 2005;Attama & Muller-Goymann, 2006;El-Kamel et al, 2007;Umeyor et al, 2012). The varied fatty acid contents of these lipids may have interacted in such a manner as to slightly disorder the crystal arrangement of the dika wax, which may have created spaces for drug localization (Attama & Muller-Goymann, 2007;Umeyor et al, 2012).…”