Evaluation of Gentamicin-Entrapped Solid Lipid Microparticles Formulated with a Biodegradable Homolipid from &lt;i&gt;Capra hircus&lt;/i&gt;

Kenechukwu, FC; Umeyor, Chukwuebuka; Momoh, Mumuni A.; Ogbonna, JDN; Sa, Chime; Nnamani, PO; Attama, AA

doi:10.4314/tjpr.v13i8.2

Cited by 14 publications

(19 citation statements)

References 15 publications

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“…This expectedly shows that the higher the gentamicin incorporated, the greater the antibacterial activity. The result of the IZD measurement as presented in table (5) is in agreement with earlier findings that the quantity of drug loaded into the lipid matrix is directly proportional to the IZD produced [24,31]. Statistically, the pharmacological effects exhibited on the microbes by different batches of the formulation vary significantly (p<0.05).…”

Section: Resultssupporting

confidence: 78%

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Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

Adedokun

Jackson

Uchegbu

et al. 2017

Int J Pharm Pharm Sci

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Objective: Despite the broad pharmacological activity of gentamicin against a number of bacteria, it's very inadequate oral bioavailability due to poor intestinal membrane permeability has limited its formulation into oral dosage delivery system. This work was thus aimed at formulation and evaluation of gentamicin-loaded microemulsions based on preparation of lipid matrix for sustained release delivery. Methods:Oral gentamicin suspensions were prepared by emulsification method using Tween 80 as a mobile surfactant in the lipid matrix dispersion. The resultant oral suspensions were evaluated for mean particle size and morphology using a photomicrograph, encapsulation efficiency/entrapment, EE (%), dispersibility, pH and absolute drug content. Release study as a function of inhibition zone diameter (IZD) and in vitro release study was also carried out. The in vitro release study was performed in both simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.2) respectively. The release data were analyzed mathematically according to zero order, first order and Higuchi equations. Results:The prepared suspensions were cream-white in colour, easily dispersed and well homogenized. Batch D, which had least amount of excipients incorporated into the lipid matrix showed clumped irregular-shaped and less free-flowing particles. The particle size was significantly influenced by lipid matrix combination ratio in the presence of a surfactant (p<0.05). The mean particle size diameters of the samples were 15.44 mm, 10.64 mm, 4.12 mm, and 2.70 mm for batches A, B, C and D respectively. The values of EE obtained varied between 47% and 59% with Batch B exhibiting the highest value. The Higuchi model gave the best release kinetics result followed by zero order kinetics. Conclusion:Oral gentamicin prepared exhibited antibacterial properties against Klebsiella spp., Escherchia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. The results suggest that a lipid matrix system could be useful as a sustained release oral delivery system of a poorly absorbable drug such as gentamicin.

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Section: Resultssupporting

confidence: 78%

“…It can, therefore, be inferred that the particle morphology and flow characteristics of the formed microparticles are influenced by the relative proportion of the lipid matrix content similar to earlier reported cases [17,24]. [12,31]. This is an affirmation of the stability of the formulations.…”

Section: Resultssupporting

confidence: 65%

Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

Adedokun

Jackson

Uchegbu

et al. 2017

Int J Pharm Pharm Sci

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“…This amorphous feature was observed at lower enthalpy and less crystallinity of the matrixes, which could lead to retention of the entrapped drug over time. The reduced crystallinity may indicate imperfect lattices leading to a special pocket that can accommodate a large number of drug molecules [23]. Hence, an increase in the quantity of PEG-4000 was observed to increase the crystallinity of the formulations, the order being as follows: A5 > A4 > A3 > A2 > A1.…”

Section: Thermal Analysismentioning

confidence: 97%

“…Moreover, particle size may be affected by one or more factors, including, among others, the degree of homogenization, homogenization speed, composition ratio, rate of particle size growth, and crystal habit of the particle [24]. During Ostward ripening, the particles tend to move towards one another, which leads to the formation of aggregates due to the kinetic advantage gain by larger crystals as a result of an increase in the concentration [23,24]. In this study, the particle size was found to increase with increasing PEG/mucin ratio.…”

Section: Morphology and Particle Size Of Insulin-loaded Mpsmentioning

confidence: 99%

Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment

et al. 2020

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In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.

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“…Gentamicin is an antibiotics belonging to the aminoglycoside group and is used in the control of severe infections caused by Gram-positive and Gramnegative microorganisms [1]. It has rapid bactericidal activity and comparatively low levels of resistance in most community and hospital associated gram-negative pathogens and these properties made it a very useful empirical drug when rapid control of a serious infection is required [2].…”

Section: Introductionmentioning

confidence: 99%

Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

Chime

Onyishi

Eze

2019

JPT

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Objective: To formulate extended release gentamicin-entrapped lipospheres using natural lipids from Irvingia wombolu (IWF) and Moringa oleifera seed (MO) popularly known as Ben oil. Methods: Different lipid combinations including IWF and Phospholipon 90H (P90H) and IWF and MO were employed in the formulation of lipospheres. The formulations were analysed for particle size, encapsulation efficiency (EE), pH stability and antimicrobial studies amongst other tests. Also the in vitro release properties were studied in Phosphate buffer pH 7.2. Results: High EE of up to 90 % were obtained for the various LM combinations. The pH was stable over 30 days and the formulations showed about 93 % release of gentamicin at 12 h. Lipospheres formulated with MO matrices showed synergism in the microbial inhibition than other formulations. Conclusion: Natural lipids from Irvingia wombolu and Moringa oleifera seed could be used in formulating oral extended release gentamicin lipospheres.

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Evaluation of Gentamicin-Entrapped Solid Lipid Microparticles Formulated with a Biodegradable Homolipid from <i>Capra hircus</i>

Cited by 14 publications

References 15 publications

Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment

Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

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