Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

Chime, Salome Amarachi; Onyishi, Ikechukwu V.; Eze, Ifeoma O.

doi:10.18314/jpt.v5i1.1594

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It provides quick bactericidal activity with reduced chances for the development of drug resistance. 48,49 Gentamicin is one of the main antibiotics used for designing sustainable release systems using nanoparticles, 50 from urinary catheter surface, 51 etc., for the effective eradication of bacterial infections. Here in this study, a novel feasible two-step chemical approach was used to modify the inert NRL film surface to an efficient antibacterial surface.…”

Section: Introductionmentioning

confidence: 99%

Natural rubber latex films with effective growth inhibition against S. aureus via surface conjugated gentamicin

Arakkal

Sirajunnisa

Sailaja

2023

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

Hospital-associated infections and related complications are of extreme concern in the healthcare sector since biofilms generated over material surfaces not only create turbulence in the healthcare practices followed but also ruin the device performance, and increased medication, leading to significant chances of drug resistance. Natural rubber latex (NRL) being the first choice for the manufacture of several conventional biomedical devices, it is essential to ensure the surfaces of the same are inherently inactive against most microorganisms. This study presents NRL film surface conjugated with a well-known antibiotic, gentamicin through an amide linkage to generate antibacterial activity to the surface with a significant growth inhibition rate, especially against Staphylococcus aureus. The NRL films were surface-oxidized under controlled acidic conditions to generate carboxyl groups exploring the unsaturation of the base monomer unit. The carboxyl group reacts with the amine groups of gentamicin facilitating its surface conjugation. The surface anchoring was authenticated by FTIR-ATR complimented further by contact angle measurement as a function of hydrophilicity and elemental analysis by EDX spectroscopy. The antibacterial efficacy of modified NRL films was evaluated using antibacterial drop test and the results indicated a substantial growth inhibition rate (>60%) against Pseudomonas aeruginosa and Staphylococcus aureus. The study could be further optimized and proposed as a viable route for the conjugation of active molecules over inert polymer molecules.

show abstract

Section: Introductionmentioning

confidence: 99%

Natural rubber latex films with effective growth inhibition against S. aureus via surface conjugated gentamicin

Arakkal

Sirajunnisa

Sailaja

2023

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

show abstract

The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery

Chime

Akpa

Attama

2019

CNM

View full text Add to dashboard Cite

Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have been used to control the release of drugs and have utility for drug targeting and hence, have been used for the delivery of various anticancer drugs and for colon targeting. Drugs encapsulated in lipids have enhanced stability due to the protection they enjoy in the lipid core of these nanoformulations. However, lipid excipients could be influenced by factors which could affect the physicochemical properties of lipid-based drug delivery systems (LBDDS). These factors include the liquid crystalline phase transition, lipid crystallization and polymorphism amongst others. However, some of the physicochemical properties of lipids made them useful as nanocarriers in the formulation of various nanoformulations. Lipids form vesicles of bilayer which have been used to deliver drugs and are often referred to as liposomes and nanoliposomes. This work aims at reviewing the different classes of lipid excipients used in formulating LBDDS and nanoformulations. Also, some factors that influence the properties of lipids, different polymorphic forms in lipid excipients that made them effective nanocarriers in nano-drug delivery would be discussed. Special considerations in selecting lipid excipients used in formulating various forms of nanoformulations would be discussed.

show abstract

Application of Molecularly Structured Ben Oil in Gentamicin Entrapped Lipospheres

Cited by 2 publications

References 13 publications

Natural rubber latex films with effective growth inhibition against S. aureus via surface conjugated gentamicin

Natural rubber latex films with effective growth inhibition against S. aureus via surface conjugated gentamicin

The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery

Contact Info

Product

Resources

About