Investigation of Sixty Extrapulmonary Tuberculosis Cases

Abstract

A An na ah ht ta ar r K Ke el li im me el le er r: : Mikobakteryum tüberkulozis; mikobakterium enfeksiyonları A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to examine cases diagnosed with extrapulmonary tuberculosis (EPTB) in the Infectious Diseases and Clinical Microbiology Department of our hospital. M Ma a--t te er ri ia al l a an nd d M Me et th ho od ds s: : EPTB cases followed up between January 2004-March 2009 were analyzed retrospectively. Medical histories, symptoms, physical, and laboratory findings, treatment and outcome of the cases were analyzed in detail and recorded. Diagnosis of extrapulmonary tuberculosis was made with bacteriologic and/or histopathologic and/or radiologic findings along with clinical findings, and responce to treatment. R Re es su ul lt ts s: : Sixty patients were included in the study. Of the cases, 35 (58%) were females and mean age was 49.5 ± 17.8 years (range 18-76). Bone-joint tuberculosis and tuberculous meningitis constituted approximately two-thirds of the cases. Other EPTB cases involved lymph node, pleura, peritoneum, urinary system and breast tuberculosis respectively in terms of frequency. Twenty-three percent of the cases multi-organ involvement. An underlying disease was present in 21 (35%) cases. General and clinical features of the cases were determined and indicated. On radiologic examination, sequel lesion was present in 25 (42%) cases and miliary involvement was present in 7 (12%) cases on chest X-ray. Acidoresistant bacilli were seen in 16 (26.7%) cases in direct microscopic examination of various samples with Ehrlicl-Ziehl-Neelsen method. Mycobacterium tuberculosis complex was recovered in 25 (42%) cases. Histopathologic evaluation of 16 out of 27 cases (59%) revealed as granulomatous inflammation. Mortality rate was 8.3% and sequela rate was 3.3%. C Co on nc cl lu us si io on n: : Tuberculosis is still an important health problem in developing countries such as Turkey. The review of EPTB cases revealed that mortality and sequela rates were low due to early diagnosis and treatment.

Evaluation Of Adult Extrapulmonary Tuberculosis Patients

“…Çalışmamızda, %42.8 oranında torakal ve %35.7 oranında torakolomber tutulumu tespit edildi. Farklı çalışmalarda da çalışmamıza benzer şekilde en sık torakal ve lomber vertebra tutulumları gözlenmiştir (6,7,18).…”