Investigation of serum and adipose tissue levels of asprosin in patients with severe obesity undergoing sleeve gastrectomy

Abstract

Objective This study aimed to reveal the relationship between obesity and asprosin (fibrillin‐1) in patients undergoing bariatric surgery and to investigate the role of asprosin in obesity etiopathogenesis. Methods The study included 37 patients who underwent laparoscopic sleeve gastrectomy for severe obesity and 37 patients who underwent laparoscopic cholecystectomy for cholelithiasis in the study and control groups, respectively. Blood samples were collected from the patients in the preoperative period to measure biochemical parameters. Blood samples were collected at 6 months postoperatively from the patients in the study group to compare their pre‐ and postoperative serum asprosin levels. Results A significant intergroup difference in terms of mean asprosin levels in adipose tissue was noted (p = 0.001). A comparison of preoperative and postoperative 6‐month serum asprosin levels in the study group showed significant differences (p = 0.021). The area under the curve of asprosin tissue levels was 78.1%, and the cutoff value was 217.34 ng/g of protein, with a sensitivity and specificity of 73.0%. Tissue levels of asprosin were found to increase the risk of obesity by a factor of 1.018 (odds ratio; 95% CI: 1.008‐1.027). Conclusions Serum asprosin levels decreased significantly at 6 months after bariatric surgery. Adipose tissue of patients with obesity showed high asprosin levels and immunoreactivity. In conclusion, asprosin levels in adipose tissue were considered a potential independent risk factor in obesity etiopathogenesis.

Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals

“…Asprosin level was considered a potential independent risk factor in obesity etiopathogenesis 37 . Considering ROC analysis results, the present study demonstrated that serum asprosin level compared to serum BDNF had an important predictive and diagnostic value in obesity.…”

“…Considering ROC analysis results, the present study demonstrated that serum asprosin level compared to serum BDNF had an important predictive and diagnostic value in obesity. Cantay et al (2022) found that serum levels of asprosin had an area under the curve (AUC) value of 53.0% and a cutoff value of 6.97 ng/mL, with 51.4% sensitivity and 48.6% specificity 37 . Another study performed the patients with obesity showed that serum levels of asprosin had an AUC value of 77.0% and a cutoff value of 144 ng/mL, with 71% sensitivity and 71% specificity 66 .…”

“…Asprosin has been found to be elevated in conditions such as obesity, type 2 diabetes, and insulin resistance, suggesting that it may play a role in the development of these metabolic disorders 37 , 38 . Exercise has been shown to have a beneficial impact on asprosin levels 39 .…”

Asprosin in health and disease, a new glucose sensor with central and peripheral metabolic effects

“…There is evidence suggesting an association between asprosin secreted levels and weight loss extent caused by bariatric surgery such as sleeve gastrectomy or cholecystectomy. Two studies reported significant decrease of serum asprosin levels after six months of weight loss surgical intervention ( 41 , 42 ). Concentrations of fasting asprosin were significantly higher in obese individuals than in normal BMI subjects with no significant sex differences ( 41 ).…”

“…Concentrations of fasting asprosin were significantly higher in obese individuals than in normal BMI subjects with no significant sex differences ( 41 ). Notably, obese group was found to express high asprosin levels and immunoreactivity in adipose tissue ( 42 ).…”