“…Mass spectrometry (MS) is one of the most powerful tools for identifying proteins [2,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] and PPIs [1,3,4,10,14,35,36], simply because it can be easily combined with IP, SDS-PAGE, chromatography, native PAGE, BN-PAGE CN-PAGE, and allows one to identify many potential interacting partners of a protein by analyzing the proteins or protein complexes (isolated and/or purified by one of the previously described methods) by Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS) or by liquid chromatographytandem mass spectrometry (LC-MS/MS), in an approach referred to as proteomics [3][4][5]14,29,30,[36][37][38][39][40][41][42]. As such, most PPIs are indirectly identified through digestion of the protein complexes purified through one of the previously described methods (i.e.…”