2013
DOI: 10.4172/2329-6798.1000e114
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Post-Translational Modification (PTM) Proteomics: Challenges and Perspectives

Abstract: The genetic revolution ushered in comprehensive understanding of genes; however, proteins are the major gene products. As the effectors of biological products, proteins warrant increased study and attention and thus, a proteomic evolution has begun. M odern C h e m istry & A p p li ca tion s

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Cited by 3 publications
(1 citation statement)
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“…Therefore, understanding the nature, quantity, and temporal progression of PTMs has arguably been one of the most substantial contributions of MS-based proteomics to modern biology 1 . However, the sub-stoichiometric nature and dynamic regulation of PTMs makes it challenging to capture and detect PTMs 11 . Thus, unique enrichment techniques and sample-processing workflows are often required for enriching PTMs before analysis by mass spectrometry 12 .…”
Section: Mainmentioning
confidence: 99%
“…Therefore, understanding the nature, quantity, and temporal progression of PTMs has arguably been one of the most substantial contributions of MS-based proteomics to modern biology 1 . However, the sub-stoichiometric nature and dynamic regulation of PTMs makes it challenging to capture and detect PTMs 11 . Thus, unique enrichment techniques and sample-processing workflows are often required for enriching PTMs before analysis by mass spectrometry 12 .…”
Section: Mainmentioning
confidence: 99%