Investigation of Polylactic Acid (PLA) Nanoparticles as Drug Delivery Systems for Local Dermatotherapy

Abstract

These results suggest that particles based on PLA polymers may be ideal carriers for hair follicle and sebaceous gland targeting.

Polymeric Nanoparticles in Dermocosmetic

“…The obtained results demonstrate in both cases that ~50% of the particles penetrated deep in the vellus hair follicles, suggesting that when the nanoparticles are in contact with the skin surface, they suffer destabilization and significant release of incorporated dye (Rancan et al, 2009). Those results later were confirmed using the same PLA nanoparticles loaded with the hydrophilic fluorochrome 4-Di-2-Asp, and with the lipophilic fluorochrome Bodipy 630/ 650.…”

Properties and medical applications of polylactic acid: A review

“…For degradable polymers, two different erosion mechanisms were proposed: homogeneous or bulk erosion and heterogeneous or surface erosion [79] (Figure 19). PLA and their copolymers in the form of nano-particles were used in the encapsulation process of many drugs, such as psychotic [80], restenosis [81], hormones [82], oridonin [83], dermatotherapy [84], and protein (BSA) [85]. Different methods were used to obtain these nano-particles, such as solvent evaporation, solvent displacement [86], salting out [80], and emulsion solvent diffusion [87].…”

“…The drug loading efficiency, encapsulation efficiency and ability of in vitro drug release of the nano-particles were investigated. Rancan et al [84] examined the use of PLA nanoparticles (PLA-NPs) loaded with fluorescent dyes as carriers for transepidermal drug delivery. PLA NPs were prepared using solvent evaporation technology.…”

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

“…The solutions were stirred with a small stir bar at 200 RPM at 32 • C. Samples were taken at different time points, lyophilized, redissolved in DMSO-d 6 and analyzed via NMR. Due to the high consumption of material, the experiment was only performed once.…”

“…The skin offers different pathways for various types of nanoparticles that address one or more of the transdermal pathways, the intracellular, intercellular, or the follicular pathway, and also target the sebaceous gland [3]. Particulate formulation has been shown to enhance both the uptake of drugs into skin in general [4,5] but also specifically into hair follicles in a size-dependent manner [6,7]. Some of the polymeric particles that are reported in the literature contain esters or are ester-based (e.g., PCL [8], PLA [6], PLGA [7]) and thus are principally biodegradable.…”