Polymeric Nanoparticles in Dermocosmetic

Abstract

SUMMARY: Recent advances in the fields of biomaterials and nanotechnology have allowed the development of advanced nanoparticles for biomedical applications. Despite a vast number of nanostructures such as liposomes, solid-lipid nanocapsules, polymeric and hybrid lipid-polymer nanoparticles have been studied as carriers for drug delivery for different pathologies with remarkable promising results; the use of polymeric nanoparticles in dermocosmetic still has not been widely explored. The evolution of cosmetic into the care skin and dermatology represents novel technological challenges. Also, the increasing knowledge about normal skin physiology and advances in nanotechnology provide an attractive environment for the creation of innovative dermocosmetic formulations. In this work, we discuss the state of the art of polymeric nanoparticles formulated for dermocosmetics, its mechanisms of action, and diffusion into the skin.

High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography

“…Nanoparticles (NPs) made of a variety of elemental compositions are now integrated into several pharmacological and cosmetic products to deliver either active ingredients or therapeutic agents to the skin. − The skin is one of the most important routes for drug and active ingredients delivery. It is also a complex and efficient barrier to their penetration in the body. , It is made of three layers: the epidermis, the dermis, and the hypodermis. , The skin acts as a barrier, and this function is largely attributed to the outmost layer, the stratum corneum (SC), which is made of overlapping layers of nonviable keratocytes called corneocytes. − …”

“…Drugs follow different routes in their passage across the skin. They can go across the cell layers of the SC (intracellular route) or follow the lipid channels between the corneocytes (intercellular route). − They can also follow the so-called transappendageal route, i.e., through the hair follicles and the sweat glands. ,,,,− One of the main strategies to increase NP permeation through the skin is by reducing their size . Small NPs of 40 nm in diameter have been reported to cross the skin 1.5 times more rapidly than larger ones (130 nm diameter) .…”

Nanotechnological Applications in Dermocosmetics

“…Polymeric particles are employed in skincare and anti-aging products in dermocosmetics because they have the ability to shield drugs and other chemicals from the environment. Additionally, it can be used to treat skin diseases such eczema, psoriasis, acne, and cutaneous mycosis [30], [31].…”

Capítulo 11 - Aplicações da nanotecnologia em desordens e patologias cutâneas

“…A penetração cutânea dos NCs poliméricos até as camadas mais profundas da pele também parece ter uma relação direta com o tamanho e a composição das nanopartículas produzidas [25][26][27] . Investigações recentes comprovaram, por técnica de microscopia confocal e análise de distribuição cutânea das nanopartículas compostas por agente fluorescente, que aproximadamente 50% das nanopartículas poliméricas de PLA ou PLGA com diâmetro de 200 nm acumularam nos folículos pilosos, sugerindo que, quando as nanopartículas estão contato com a superfície da pele, elas sofrem desestabilização com liberação significativa de agente fluorescente incorporado 27 . Além disso, foi observado que a cinética de liberação do agente fluorescente depende da sua lipofilicidade e, por isso, pode ser facilmente modulada incorporando componentes com diferentes graus de lipofilia 28 .…”