Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs

Abstract

Caralluma is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely, Caralluma penicillata (C. penicillata) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of C. penicillata against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with/without indomethacin were performed. The results showed that a 400 mg/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10 mg/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.

Russelioside B: a Pregnane Glycoside with Pharmacological Potential

“…attenuata (Garg et al 2016), C. quadrangula (Ibrahim et al 2016) and C. penicillata (Deflers) N.E.Br. (Albaser et al 2014).…”

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“…Antiadipogenesis [100] Antiproliferative [67] Cytotoxic [68] Immunostimulating [70] Boucerosia diffusa Antiangiogenic [79] Boucerosia indica Antimicrobial [63] Caralluma nilagiriana Antibacterial [72] Boucerosia truncato-coronata Antioxidant [78] Antiangiogenic [79] Caralluma pauciflora Cytotoxic,antimicrobial, and antioxidant [101] Caralluma penicillata Anti-inflammatory and gastritis protection [74] Antiplasmodial, antitrypanosomal, and antileishmanial [73] Caralluma sinaica Anticancer and antifolate activities [76] Antidiabetic [77] Caralluma longidens Antimicrobial [95] Caralluma quadrangula Antimicrobial [75] Antidiabetic [118] Caralluma negevensis Anticancer [13] Caralluma acutangula Anticancer [28] property against indomethacin in guinea pigs. The extract was also tested for acute anti-inflammatory activity, and single dose of extract was equally active as that of indomethacin but shorter in time duration.…”

“…At the same time, combination of extract and indomethacin minimized the gastritis property of indomethacin depending on ulcer index. [74]…”

Investigation Effect of Aloe Vera in Fresh Gel Form on Rabbit’s Model Wound

“…Several plants were tested pharmacologically activity (anti-inflammatory, anti-microbial, antidiabetes …etc) in Yemen [1][2][3][4]. "This study presents the genus Aloe that belongs to the family Xanthorrhoeaceae that was already mentioned more than 4000 years ago in a collection of Sumerian clay tablets dated 2100 BC" [1].…”

“…"This study presents the genus Aloe that belongs to the family Xanthorrhoeaceae that was already mentioned more than 4000 years ago in a collection of Sumerian clay tablets dated 2100 BC" [1]. "Aloe was also mentioned as a laxative in the Egyptian Papyrus Ebers from 1552 BC" [2]. "Aloe vera contains 75 potentially active constituents: vitamins, enzymes, minerals, sugars, anthraquinones, hormones, lignin, saponins, salicylic acids and amino acids" [3][4][5].…”