Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-α treatment

Dikici, Ismail; Mehmetoğlu, İdris; Dikici, Nebahat; Bitirgen, Mehmet; Kurban, Sevil

doi:10.1016/j.clinbiochem.2005.10.006

Cited by 50 publications

(31 citation statements)

References 17 publications

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“…Also, El-Kannishy et al proved that patients with CHC had significantly higher oxidative stress, which can lead to chronic inflammation (45). Moreover, Dikici et al found that patients with CHC had increased oxidative stress and decreased levels of some important antioxidants such as GSH and β-carotene are in accordance with the findings of other investigators (46)(47)(48)(49)(50). Indeed, it has been shown that the amount of reactive oxygen species (ROS) found in healthy human livers was significantly lower than values found in the liver affected hepatitis C (51).…”

Section: Resultssupporting

confidence: 79%

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Al-Jiffri

2016

Electron J Gen Med

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Objective: As oxidative status may be an influential factor for increasing the progress of the disease and decreasing the effectiveness of the treatment, the aim of this study was to measure the oxidative stress and anti-oxidative markers among Saudi patients with chronic hepatitis C (CHC) versus nonalcoholic steatohepatitis (NASH). Methods: This study was carried out on a sample of 150 consecutive patients (75 with CHC and 75 with NASH), selected from gastroenterology outpatient clinic, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Also, this study included 75 healthy volunteers, mostly, relatives of the patients who came with them to the clinic. Measurements of oxidative stress and anti-oxidative stress markers were measured for all participants. Results:The mean values of oxidative stress markers included conjugated dienes (CD), malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) were significantly elevated in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly elevated in patients with NASH than patients with CHC. However, the mean values of anti-oxidative stress markers include glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione (GSH), arylesterase (AE) and paraoxonase (PON) were significantly reduced in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly reduced in patients with NASH than patients with CHC. Conclusion: In this study, patients with NASH have higher levels of oxidative and lower anti-oxidant markers than patients with CHCs.

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Section: Resultssupporting

confidence: 79%

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Al-Jiffri

2016

Electron J Gen Med

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“…It can be argued that increased lipid peroxidation is caused by the inflammation related to viral infection, and the decreased antioxidant levels may be an early marker of the oxidative stress. Lipid peroxides formed can be chemotactic for the neutrophils causing increased inflammation, which further drives oxidant-mediated injury in the liver (20). The results presented confirm the involvement of the oxidative stress as a part of the pathophysiology of CHC.…”

Section: Discussionsupporting

confidence: 71%

Oxidative Stress Biomarkers in Urine of Patients with Hepatitis B and C

Kökoğlu¹,

Uçmak²,

Kurutaş³

et al. 2012

Balkan Med J

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Objective: The aim of our study is to determine the role of oxidative stress biomarkers in hepatic damage in hepatitis B virus (HBV) and hepatitis C virus (HCV)-infected patients.Materials and Methods: Forty-eight patients with chronic hepatitis B, 15 patients with chronic hepatitis C and 30 healthy individuals as a control group were included in this study. Serum alanine-aminotransferase (ALT) and aspartate aminotransferase (AST) levels, urine oxidative stress biomarkers such as malondialdehyde (MDA) levels, superoxide dismutase (SOD-1) and catalase (CAT) activities were measured.Results: Urine MDA levels increased in patients with HBV and HCV compared to the control group. It was higher in HCV patients than HBV patients (p<0.001). Besides, while CAT and SOD-1 activities were decreased in the urine of patients with HCV, they increased in the urine of patients with HBV compared to controls (p<0.05). Furthermore, urine CAT ve SOD-1 activities in patients with HBV were statistically significantly higher than those of the HCV patients (p<0.001).Conclusion: Increase in urine MDA levels in hepatitis forms may be valuable in monitoring in viral hepatitis cases. Also, we thought that insufficiency of antioxidant barrier in patients with HCV may cause oxidative damage, so antioxidant treatment may useful and should be added to the combined therapy for these patients.

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“…Previous studies demonstrated that oxidative stress played an important role in the process of HBV infection (Bolukbas et al 2005;Dikici et al 2005;Lin et al 2011). MDA and TNF-α, which were markers for oxidative stress, Glutathione-S-transferases (GSTs) can protect cells against damages from toxic substances (Hayes and McLellan 1999;Tew and Ronai 1999).…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that 780,000 people die from HBV infection every year. Although the inner mechanism for HBV infection is still not fully understood, many studies have demonstrated that oxidative stress plays an important role in the development and progression of HBV infection (Bolukbas et al 2005;Dikici et al 2005;Lin et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Methylation of the Glutathione-S-Transferase P1 Gene Promoter Is Associated with Oxidative Stress in Patients with Chronic Hepatitis B

Fan

et al. 2016

Tohoku J. Exp. Med.

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Glutathione-S-transferase P1 (GSTP1) and glutathione-S-transferase M3 (GSTM3) catalyze the glutathione-related clearance of xenobiotics. The methylation of these gene promoters was associated with oxidative stress that induced liver damage. This study aims to explore the relationship among GSTP1 and GSTM3 methylation, DNA methyltransferases (DNMTs) expression, and oxidative stress in patients with chronic hepatitis B (CHB). We retrospectively enrolled 153 patients with CHB and 40 healthy controls (HCs). The GSTP1 and GSTM3 methylation status, DNMTs mRNA levels in peripheral mononuclear cells (PBMCs) and TNF-α and malondialdehyde (MDA) levels in plasma were detected. GSTP1 methylation was significantly higher in patients with CHB than HCs (P = 0.047). Patients with HBeAg-positive CHB showed significantly higher GSTP1 methylation than those with HBeAg-negative CHB (P = 0.017) and HCs (P = 0.007). No significant difference was observed between GSTP1 methylation in HBeAg-negative CHB and HCs (P = 0.191). DNMT1 and DNMT3a mRNA levels were significantly higher in participants with GSTP1 methylation than those without. In patients with CHB, the degree of GSTP1 promoter methylation was significantly correlated with DNMT1 mRNA, DNMT3a mRNA, TNF-α, MDA, HBeAg, ALT, AST and TBIL. In contrast, no significant difference was found between GSTM3 methylation in patients with CHB and HCs (P = 0.079). Meanwhile, no significant difference could be observed between GSTM3 promoter methylation in patients with HBeAg-positive CHB and HBeAg-negative CHB (P = 0.146). Therefore, this study demonstrated that GSTP1 hypermethylation was associated with DNMT1, DNMT3a overexpression and oxidative stress in patients with HBeAg-positive CHB.

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Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-α treatment

Cited by 50 publications

References 17 publications

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Oxidative Stress Biomarkers in Urine of Patients with Hepatitis B and C

Methylation of the Glutathione-S-Transferase P1 Gene Promoter Is Associated with Oxidative Stress in Patients with Chronic Hepatitis B

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