Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus

Abstract

There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA1c in patients with type 2 diabetes mellitus.

Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease

“…Also, a similar association between NLR and metabolic disorders was recently reported by Buyukkaya et al [36], showing a positive association between serum glucose and NLR elevation, although HbA 1c values were not assessed in these patients. However, in contrast to our present data, Sefil et al [37] found a positive association between NLR and glycosylated haemoglobin levels, albeit in a small population of diabetics with poor glycaemic control. Moreover, a previous study had reported no relationship between neutrophil activation in diabetics and HbA 1c [23].…”

Neutrophil–Lymphocyte ratio is associated with arterial stiffness in diabetic retinopathy in type 2 diabetes

“…Increased retinal neutrophil count damages retinal vascular endothelial cells and blood-retinal barrier through a Fas-Fas ligand-dependent pathway (Harris, Skalak, and Hatchell, 1994;Joussen et al, 2003;McLeod, Lefer, Merges, and Lutty, 1995). Recent reports confirmed that NLR is increased in T2DM and DR (Sefil et al, 2014;Shiny et al, 2014;Woo et al, 2011). In addition, elevated NLR was independently related with the severity of DR (Woo et al, 2011).…”

“…Moreover, NLR predicts presence, severity and extent of coronary artery disease, myocardial infarction in high risk patients for coronary artery disease, and peripheral arterial disease prognostication (Arbel et al, 2012;Bhat et al, 2013;Duffy et al, 2006;Horne et al, 2005;Nunez et al, 2008). More recently, some reports revealed that NLR is associated with glycated hemoglobin, different grades of glucose intolerance and insulin resistance, and the severity of DR (Sefil et al, 2014;Shiny et al, 2014;Woo, Ahn, Ahn, Park, and Lee, 2011).…”

“…Furthermore, increased NLR is associated with elevated hemoglobin A1c (HbA1c) levels in T2DM (Sefil et al, 2014). However, little research has been conducted to investigate the relationship between NLR and baPWV in DR.…”

Premarital Hemoglobinopathy Screening Study: Is Kadirli Prevalent Thalassemia Area Of Turkey?

“…Türkiye'de beta-talasemi taşıyıcılığının Çukurova, Hatay, İçel ve Antalya'yı içeren yüksek riskli bölgelerde popülasyon ortalamasının üzerine çıkmaktadır [1,3,4,16]. Bizim çalışmamızda evlilik öncesi taraması yapılan bireylerde beta-talasemi taşıyıcılığı %4.91 ile Türk Hemoglobinopati Konseyi tarafından yapılan çalışmadaki 16 şehrin ortalamasından yüksek tespit edilmiştir [18].…”