Investigation of neuropsychological characteristics of very mild and mild dementia with Lewy bodies

Petrová, Magdalena; Pavlova, Radka; Zhelev, Yavor; Mehrabian, Shima; Raycheva, Margarita; Traykov, Latchezar

doi:10.1080/13803395.2015.1117058

Cited by 17 publications

(14 citation statements)

References 32 publications

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“…Verbal dynamic performance in the PDD group was modulated by dopaminergic stimulation; this modulation did not extend to nonverbal design fluency or other cognitive functions assessed, suggesting that this may be a relatively specific effect on verbal output. Taken together, our findings are in line with previous evidence for impaired organization of language output in parkinsonism (Petrova et al, 2016) but suggest a more specific limitation of verbal generation. Besides corroborating previous work showing reduced verbal fluency in parkinsonism (Herrera, Cuetos, & Ribacoba, 2012), the profiles of verbal adynamia exhibited by both our patient groups were broadly in keeping with the findings documented in previous detailed case studies of patients with PSP and dynamic aphasia (Esmonde et al, 1996; Robinson et al, 2006; Robinson et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

“…Verbal fluency deficits are well described in PD and are likely in part to reflect motor slowing together with executive compromise. Such deficits may also signify the involvement of language generation mechanisms and may help differentiate parkinsonian disorders, potentially while clinical disease is still mild (Petrova et al, 2016; Rittman et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Magdalinou¹,

Golden

Nicholas

et al. 2018

Neurocase

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Verbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, progressive supranuclear palsy and corticobasal degeneration. All disease groups showed impaired verbal fluency and sentence generation versus healthy age-matched controls, after adjusting for general linguistic and executive factors. Dopaminergic stimulation in the Parkinson’s group selectively improved verbal generation versus other cognitive functions. Voxel-based morphometry identified left inferior frontal and posterior superior temporal cortical correlates of verbal generation performance. Verbal adynamia warrants further evaluation as an index of language network dysfunction and dopaminergic state in parkinsonian disorders.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Magdalinou¹,

Golden

Nicholas

et al. 2018

Neurocase

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“…More precisely, they scored lower than HCs in verbal production (i.e., formal semantic evocation) as well as in oral naming. These results are in line with some studies (e.g., [28, 63]) but contrast with studies showing a relative preservation of naming abilities in DLB (e.g., [64]). However, when language difficulties are present, the underlying mechanisms are not fully elucidated [16].…”

Section: Discussionsupporting

confidence: 89%

“…These findings are in line with the suggestion that impairment in non-memory domains (e.g., executive function, visuospatial abilities) is more likely to progress to DLB than single-domain amnestic mild cognitive impairment (MCI) [25, 27]. Researchers in a recent study assessed cognition in mild and very mild DLB [28]. The authors found that very mild DLB was associated with impairment of attentional/executive, visuospatial, visuoconstructive and naming abilities, as well as with difficulties in retrieval of episodic memory.…”

Section: Introductionsupporting

confidence: 80%

Cognitive profile in prodromal dementia with Lewy bodies

et al. 2017

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BackgroundCortical and subcortical cognitive impairments have been found in dementia with Lewy bodies (DLB). Roughly, they comprise visuoconstructive and executive dysfunction, whereas memory would remain relatively spared. However, the cognitive profile of patients with prodromal DLB remains poorly illustrated to date.MethodsWe included 37 patients with prodromal DLB (age 67.2 ± 8.6 years, 18 men, Mini Mental State Examination [MMSE] score 27.4 ± 2) and 29 healthy control subjects (HCs; age 68.8 ± 7.9 years, 15 men, MMSE score 29.0 ± 0.9). They were presented with an extensive neuropsychological test battery to assess memory; speed of processing; executive function; visuoperceptual, visuospatial and visuoconstructive abilities; language; and social cognition.ResultsCompared with HCs, patients had lower scores on a visual recognition memory test (Delayed Matching to Sample-48 items; p ≤ 0.021) and lower free recall (all p ≤ 0.035), but not total recall, performance on a verbal episodic memory test (Free and Cued Selective Reminding Test). Short-term memory (p = 0.042) and working memory (p = 0.002) scores were also lower in patients. Assessment of executive function showed no slowing but overall lower performance in patients than in HCs (all p ≤ 0.049), whereas assessment of instrumental function yielded mixed results. Indeed, patients had lower scores on language tests (p ≤ 0.022), apraxia for pantomime of tool use (p = 0.002) and imitation of meaningless gesture (p = 0.005), as well as weakened visuospatial abilities (p = 0.047). Visuoconstruction was also impaired in patients. However, visuoperceptual abilities did not differ between groups. Finally, theory of mind abilities were lower in patients than in HCs (p < 0.05), but their emotion recognition abilities were similar.ConclusionsThis study presents the cognitive profile in patients with prodromal DLB. In line with the literature on DLB with dementia, our results show lower performance on tests of executive function and visuoconstruction. However, we found, from a prodromal stage of DLB, memory (free recall and visual recognition) and social cognition deficits, as well as weakened visuospatial and praxic abilities.

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“…The pattern of verbal-learning deficits in RBD patients reported by Marchand(Marchand et al 2016) is similar to that reported in PD and mild DLB patients(Costa et al 2014, Petrova et al 2016). Adding a visuospatial task to the neuropsychological assessment increases the ability to predict the conversion to dementia in RBD patients, which is consistent with the prominent attention/executive functions and visuospatial declines noted early in DLB patients and in PD patients at risk of dementia(Goldman and Postuma 2014).…”

Section: Factors In Prediction Of Phenoconversion To Alpha-synucleinosupporting

confidence: 87%

Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies

Barone

Henchcliffe

2018

Clinical Neurophysiology

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Rapid eye movement (REM) sleep behavior disorder (RBD) involves REM sleep without atonia in conjunction with a recurrent nocturnal dream enactment behavior, with vocalizations such as shouting and screaming, and motor behaviors such as punching and kicking. Secondary RBD is well described in association with neurological disorders including Parkinson's disease (PD), multiple system atrophy (MSA), and other conditions involving brainstem structures such as tumors. However, RBD alone is now considered to be a potential harbinger of later development of neurodegenerative disorders, in particular PD, MSA, dementia with Lewy bodies (DLB), and pure autonomic failure. These conditions are linked by their underpinning pathology of alpha-synuclein protein aggregation. In RBD, it is therefore important to recognize the potential risk for later development of an alpha-synucleinopathy, and to investigate for other potential causes such as medications. Other signs and symptoms have been described in RBD, such as orthostatic hypotension, or depression. While it is important to recognize these features to improve patient management, they may ultimately provide clinical clues that will lead to risk stratification for phenoconversion. A critical need is to improve our ability to counsel patients, particularly with regard to prognosis. The ability to identify who, of those with RBD, is at high risk for later neurodegenerative disorders will be paramount, and would in addition advance our understanding of the prodromal stages of the alpha-synucleinopathies. Moreover, recognition of at-risk individuals for neurodegenerative disorders may ultimately provide a platform for the testing of possible neuroprotective agents for these neurodegenerative disorders.

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Investigation of neuropsychological characteristics of very mild and mild dementia with Lewy bodies

Abstract: In the present work we found that faster progression to the mild DLB stage in the first few years of the disease is mainly related to deterioration of memory, attention/executive functions, and visuospatial abilities, as well as an increased frequency of visual hallucinations.

Cited by 17 publications

References 32 publications

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Cognitive profile in prodromal dementia with Lewy bodies

Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies

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