Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003

Atrasheuskaya, Alena; Blatun, E.M.; Kulak, Mikhail V.; Atrasheuskaya, A. V.; Karpov, Igor; Rubin, Steven A.; Ignatyev, G. M.

doi:10.1016/j.vaccine.2007.04.020

Cited by 23 publications

(26 citation statements)

References 33 publications

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“…Despite the fact that the Jeryl Lynn vaccine (genotype A) has been shown to be effective in outbreaks caused by MuV belonging to genotype G, moreintensive assessments of mumps outbreaks should potentially include IgG avidity testing as well as a comprehensive assessment of the functional antibody response in order to ascertain the ability of serum antibody to neutralize both the vaccine virus and the endemic challenge virus strain (2,10). The first genotype G strain identified in 1996 (Glou1/UK96, GenBank accession number AF142764), later named G1, was not detected in this study; however, numerous genotype G variants have been detected since 2000 (8,23), and the subgenotype genetic diversity can be up to 7%.…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

et al. 2010

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“…Meanwhile, all H2 viruses except Be1/UK88 strain share a histidine at position 9, which is also common in H1 and H2 viruses. These amino acid sequence properties suggest that subgenotype H2 may be an ancestral group of genotype H viruses and that the Be1/ UK88 strain may be phylogenetically closest to an ancestral virus of genotype H. Genotype H viruses mainly circulated in the western hemisphere (3,5,6,20). However, since both the ancestral virus (SA475/JPN97) and the highly differentiated progenies (the Mongolian MuVs) were isolated from East Asia, genotype H3 viruses may have been indigenous to this area for more than 10 years.…”

Section: Vol 49 2011 Mumps Genotype In Mongolia 1921mentioning

confidence: 97%

Characterization of Mumps Viruses Circulating in Mongolia: Identification of a Novel Cluster of Genotype H

et al. 2011

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Although mumps virus is still causing annual epidemics in Mongolia, very few epidemiological and virological data have been reported. We describe here the first phylogenetic analysis data on the mumps viruses circulated in Mongolia in 2009. We detected 21 mumps virus cDNAs and obtained a virus isolate from 32 throat swabs of mumps patients in Ulaanbaatar, the capital of Mongolia. The phylogenetic analyses based on the 316 nucleotides of the small hydrophobic gene show that these sequences form a single cluster, with the closest relatedness to the viruses belonging to genotype H. According to the recommendation of the World Health Organization, Mongolian mumps viruses could be classified into a novel genotype because the divergence between new sequences and genotype H reference viruses is >5% (6.3 to 8.2%). However, additional analyses based on the fusion gene, the hemagglutinin-neuraminidase gene, and the whole-genome indicate that the divergences between the Mongolian isolate and other genotype H strains never exceed the within-genotype divergences of other genotypes. These results suggest that Mongolia strains should be included in genotype H and that the current criteria for mumps virus genotyping should be revised. We propose here that the Mongolian viruses should be classified as a new subgenotype termed H3. Since previous epidemiological studies suggested that genotypes H may be associated with central nervous system diseases, we evaluated the neurovirulence of the Mongolian isolate in the neonatal rat system. However, the virus does not exhibit prominent neurovirulence in rats.

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“…The prevailing view [14,15] is that most mumps vaccine failures are attributable to primary vaccine failure. This view is challenged, and with good reasoning [16][17][18][19].…”

Section: Mumps Immunology: a Complex Issuementioning

confidence: 99%

“…Here, we arrive at a complex issue-the differences between different mumps vaccine strains (or, preferably, substrains) [19,28]. The main practical problem is that, although several tests are used, no serological test reliably predicts who is at risk and who is not [22]; association between positive ELISA or other serological test results and clinical protection is especially poor in mumps vaccination.…”

Section: Mumps Immunology: a Complex Issuementioning

confidence: 99%

Mumps Outbreaks in Canada and the United States: Time for New Thinking on Mumps Vaccines

Peltola

Kulkarni

Kapre

et al. 2007

Clinical Infectious Diseases

133

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Mumps epidemics in Canada and the United States prompted us to review evidence for the effectiveness of 5 different vaccine strains. Early trials with the Jeryl Lynn vaccine strain demonstrated an efficacy of approximately 95%, but in epidemic conditions, the effectiveness has been as low as 62%; this is still considerably better than the effectiveness of another safe strain, Rubini (which has an effectiveness of close to 0% in epidemic conditions). The Urabe vaccine strain has an effectiveness of 54%-87% but is prone to cause aseptic meningitis. Little epidemiological information is available for other vaccines. The Leningrad-Zagreb vaccine strain, which is widely used in developing countries and costs a fraction of what vaccines cost in the developed world, seems to have encouraging results; in 1 study, the effectiveness of this vaccine exceeded 95%. Aseptic meningitis has also been reported in association with this vaccine, but the benign nature of the associated meningitis was shown recently in Croatia. Also, the Leningrad-3 strain seems to be effective but causes less-benign meningitis. No mumps vaccine equals the best vaccines in quality, but the virtually complete safety of some strains may not offset their low effectiveness. Epidemiological data are pivotal in mumps, because serological testing is subject to many interpretation problems.

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Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003

Cited by 23 publications

References 33 publications

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

Characterization of Mumps Viruses Circulating in Mongolia: Identification of a Novel Cluster of Genotype H

Mumps Outbreaks in Canada and the United States: Time for New Thinking on Mumps Vaccines

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