Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(ε-caprolactone) Electrospun Nanofibrous Matrices

Bikiaris, Nikolaos D.; Koumentakou, Ioanna; Michailidou, Georgia; Kostoglou, Margaritis; Vlachou, Marilena; Barmpalexis, Panagiotis; Karavas, Evangelos; Papageorgiou, George Z.

doi:10.3390/pharmaceutics14081693

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…The incorporation of the extract in the fibers was corroborated since the transmittance band of the carbonyl characteristic of PCL (C=O) at 1719 cm -1 had a slight shift to higher values of 1723 cm -1 for PCL_5.3 and 1726 cm -1 for the sample with 10.6 wt. % (PCL_10.6), which can be attributed to the formation of intermolecular hydrogen bonds between PCL and the P. major extract [35,65].…”

Section: Fourier Transformation Infrared -Ftirmentioning

confidence: 99%

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Mancipe¹,

Queiroz²,

Santos³

et al. 2023

Preprint

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Plantago major L. is a worldwide available plant that has been used traditionally for several medical application due to its properties such as wound healing, anti-inflammatory, antimicrobial etc. This work aimed to develop and evaluate nanostructured PCL electrospun dressing with P. major extract encapsulated in nanofibers for application in wound healing. The extract from leaves was obtained by extraction in a mixture of water:ethanol= 1:1 of the freeze-dried extract presented a minimum inhibitory concentration (MIC) for Staphylococcus Aureus susceptible and resistant to methicillin of 5.3 mg/mL, a high antioxidant capacity, but a low content of total flavonoids. Electrospun mats without defects were successfully produced using two P. major extract concentrations based on MIC value. The extract incorporation in PCL nanofibers was confirmed by FTIR and contact angle measurements. The PCL/P. major extract was evaluated by DSC and TGA demonstrating that incorporation of the extract decreases the thermal stability of the mats as well as the degree of crystallinity of PCL-based fibers. The P. major extract incorporation on electrospun mats produced a significant swelling degree (more than 400%) and increased the capacity of adsorbing wound exudates and moisture, important characteristics for skin healing. The extract-controlled release evaluated by in vitro study in PBS (pH, 7.4) shows that P. major extract delivery from the mats occurs in the first 24 h, demonstrating their potential capacity to be used in wound healing.

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Section: Fourier Transformation Infrared -Ftirmentioning

confidence: 99%

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Mancipe¹,

Queiroz²,

Santos³

et al. 2023

Preprint

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show abstract

“…Furthermore, the surface erosion of the PCL matrix causes the fibers’ surface to become rough. According to this finding, the breakdown process begins at the PCL fibers’ surface and moves inside the particles [ 50 , 51 ]. This may indicate re-crystallization of the guest polymer [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections

Paczkowska-Walendowska,

Ignacyk,

Miklaszewski

et al. 2024

Materials

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Pomegranate peel extract is known for its potent antibacterial, antiviral, antioxidant, anti-inflammatory, wound healing, and probiotic properties, leading to its use in treating oral infections. In the first stage of this work, for the first time, using the Design of Experiment (DoE) approach, pomegranate peel extract (70% methanol, temperature 70 °C, and three cycles per 90 min) was optimized and obtained, which showed optimal antioxidant and anti-inflammatory properties. The optimized extract showed antibacterial activity against oral pathogenic bacteria. The second part of this study focused on optimizing an electrospinning process for a combination of polycaprolactone (PCL) and polyvinylpyrrolidone (PVP) nanofibers loaded with the optimized pomegranate peel extract. The characterization of the nanofibers was confirmed by using SEM pictures, XRPD diffractograms, and IR-ATR spectra. The composition of the nanofibers can control the release; in the case of PVP–based nanofibers, immediate release was achieved within 30 min, while in the case of PCL/PVP, controlled release was completed within 24 h. Analysis of the effect of different scaffold compositions of the obtained electrofibers showed that those based on PCL/PVP had better wound healing potential. The proposed strategy to produce electrospun nanofibers with pomegranate peel extract is the first and innovative approach to better use the synergy of biological action of active compounds present in extracts in a patient-friendly pharmaceutical form, beneficial for treating oral infections.

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“…This initial burst release is unavoidable [ 91 ]. Consequently, the biphasic release rate of drug-loaded nanofibers is influenced by factors such as the polymer molecular weight [ 92 ], concentration [ 93 ], sheath thickness [ 94 ], additives, and more. For instance, introducing graphene oxide can enhance the mechanical properties of electrospun membranes and slow the release of model drugs by reducing the matrix swelling [ 95 ].…”

Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

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Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(ε-caprolactone) Electrospun Nanofibrous Matrices

Cited by 6 publications

References 60 publications

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

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