Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries

Malamitsi‐Puchner, Ariadne; Vrachnis, Nikolaos; Samoli, Evangelia; Baka, Stavroula; Alexandrakis, George; Puchner, Karl Philipp; Iliodromiti, Zoe; Hassiakos, Dimitrios

doi:10.1155/mi/2006/94381

Cited by 15 publications

(13 citation statements)

References 41 publications

(35 reference statements)

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“…33,34 Well known common causes leading to preterm birth include stress, systemic or maternal genital tract infections, placental ischemia or vascular lesions, and uterine overdistension. 35,36 It is reasonable to hypothesize that under these circumstances the placental "clock" is triggered sooner than normal to initiate the cascade of events leading to labor.…”

Section: Preterm Labormentioning

confidence: 99%

Endocrine, paracrine, and autocrine placental mediators in labor

Iliodromiti¹,

Antonakopoulos²,

Sifakis³

et al. 2012

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considering that preterm birth accounts for about 6-10% of all births in Western countries and of more than 65% of all perinatal deaths, elucidation of the particularly complicated mechanisms of labor is essential for determination of appropriate and effective therapeutic interventions. Labor in humans results from a complex interplay of fetal and maternal factors, which act upon the uterus to trigger pathways leading gradually to a coordinated cervical ripening and myometrial contractility. Although the exact mechanism of labor still remains uncertain, several components have been identified and described in detail. Based on the major role played by the human placenta in pregnancy and the cascade of labor processes activated via placental mediators exerting endocrine, paracrine, and autocrine actions, this review article has aimed at presenting the role of these mediators in term and preterm labor and the molecular pathways of their actions. some of the aforementioned mediators are involved in myometrial activation and preparation and others in myometrial stimulation leading to delivery. In the early stages of pregnancy, myometrial molecules, like progesterone, nitric oxide, and relaxin, contribute to the retention of pregnancy. At late stages of gestation, fetal hypothalamus maturation signals act on the placenta causing the production of hormones, including crH, in an endocrine manner; the signals then enhance paracrinically the production of more hormones, such as estrogens and neuropeptides, that contribute to cervical ripening and uterine contractility. These molecules act directly on the myometrium through specific receptors, while cytokines and multiple growth factors are also produced, additionally contributing to labor. In situations HORMONES 2012, 11(4):397-409 Review

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Section: Preterm Labormentioning

confidence: 99%

Endocrine, paracrine, and autocrine placental mediators in labor

Iliodromiti¹,

Antonakopoulos²,

Sifakis³

et al. 2012

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“…[3][4][5][6][7][8] Recent studies have shown that elevated biomarkers of intraamniotic infection and/or inflammation in the mid-trimester period in otherwise uncomplicated and asymptomatic pregnancies are associated with an increased risk of subsequent preterm delivery in singleton gestations, [9][10][11][12] although not all investigators were able to demonstrate this association. 13,14 However, there is a paucity of information regarding the relationship between biomarkers of inflammation in mid-trimester amniotic fluid (AF) and the risk of subsequent preterm delivery in twins. Considering the high risk of preterm birth in multi-fetal gestations, the identification of inflammatory biomarkers that could predict spontaneous preterm birth in this cohort is an urgent issue.…”

Section: Introductionmentioning

confidence: 99%

Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study

et al. 2015

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“…Inflammation is a major factor in preterm and term delivered infants (Malamitsi-Puchner, Vrachnis et al 2006) with regard to perinatal brain damage, including CP (Dammann and Leviton 1997;Volpe 2009). Intrauterine inflammation may lead to fetal inflammatory response syndrome (FIRS), clinical chorioamnionitis or clinically silent histological chorioamnionitis (Vrachnis, Vitoratos et al 2010).…”

Section: Intrauterine Infection / Inflammationmentioning

confidence: 99%