2012
DOI: 10.14310/horm.2002.1371
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Endocrine, paracrine, and autocrine placental mediators in labor

Abstract: considering that preterm birth accounts for about 6-10% of all births in Western countries and of more than 65% of all perinatal deaths, elucidation of the particularly complicated mechanisms of labor is essential for determination of appropriate and effective therapeutic interventions. Labor in humans results from a complex interplay of fetal and maternal factors, which act upon the uterus to trigger pathways leading gradually to a coordinated cervical ripening and myometrial contractility. Although the exact… Show more

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Cited by 59 publications
(49 citation statements)
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“…While the increasing concentration of estrogen stimulates the rise in uterine oxytocin receptors towards the initiation of labor in women and other animal species (Blanks et al, 2003;Spencer et al, 2004), we could not find a correlation between estrogen concentration and the expression of placental OTR mRNA. The placenta is considered to be one of the OT-synthesizing organs responsible for stimulating endometrial PGF2α production, resulting in luteolysis at the beginning of labor (Iliodromiti et al, 2012). In dogs, we could not show a link among estrogen concentration, the increase in placental oxytocin receptors at term pregnancy and the initiating of labor.…”
Section: Discussioncontrasting
confidence: 71%
“…While the increasing concentration of estrogen stimulates the rise in uterine oxytocin receptors towards the initiation of labor in women and other animal species (Blanks et al, 2003;Spencer et al, 2004), we could not find a correlation between estrogen concentration and the expression of placental OTR mRNA. The placenta is considered to be one of the OT-synthesizing organs responsible for stimulating endometrial PGF2α production, resulting in luteolysis at the beginning of labor (Iliodromiti et al, 2012). In dogs, we could not show a link among estrogen concentration, the increase in placental oxytocin receptors at term pregnancy and the initiating of labor.…”
Section: Discussioncontrasting
confidence: 71%
“…Although we emphasize the association between progesterone and serum cytokines concentrations, interactions among steroid hormones, hypothalamic-pituitary hormones, neuropeptides, growth factors, and cytokines should be also considered to understand the complex immunological response during active labor [47] . Specifically, a relevant hormone is prolactin (PRL), which has been proposed as a key hormone during delivery.…”
Section: Discussionmentioning
confidence: 99%
“…This could explain the similar trend observed for these two markers. Under physiological conditions, the secretion of ÎČ -hCG is stimulated by estrogens, while it is inhibited by progesterone [58]. ÎČ -hCG promotes differentiation and invasion of the trophoblast and has immunomodulatory properties [21].…”
Section: Discussionmentioning
confidence: 99%