Investigation of intraplacental villous arteries by doppler flow imaging in growth-restricted fetuses

Mu, Jun; Kanzaki, Toru; Tomimatsu, Takuji; Fukuda, Hirotuga; Fujii, Eriko; Takeuchi, Hisaya; Murata, Yuji

doi:10.1067/mob.2002.119807

Cited by 18 publications

(18 citation statements)

References 19 publications

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“…The data presented herein correlate with the results of histopathological and 2D Doppler studies [16, 17]. A major advantage of 3D Power Doppler technique, in comparison to the above-mentioned techniques, is the possibility of quantitative evaluation of placental vascular indices for the entire placental volume during the pregnancy.…”

Section: Discussionsupporting

confidence: 72%

Comparative analysis of placental vasculature and placental volume in normal and IUGR pregnancies with the use of three-dimensional Power Doppler

Pomorski

Zimmer

Florjański

et al. 2011

Arch Gynecol Obstet

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ObjectivesTo evaluate the differences in placental vascular indices and placental volume between normal and IUGR pregnancies.MethodsA prospective study was conducted on a group of 100 normal and 20 IUGR pregnancies between 22 and 42 weeks of gestation. For the purpose of evaluation of placental volume and placental vascular indices, we applied 3D Power Doppler and VOCAL technique. Only patients with entirely visualized placenta were included in the study.ResultsA comparative analysis of vascularization index (VI), vascularization flow index (VFI), flow index (FI), and placental volume (PV) revealed statistically significant differences between normal and IUGR pregnancies.In normal pregnancies, the volume of the placenta was on average 92.42 cm3 larger than in pregnancies complicated by IUGR. Receiver operating characteristic (ROC) curves were used to evaluate the clinical usefulness of placental vascular indices and placental volume for discriminating IUGR and normal pregnancies. It was concluded that the VI, VFI, PV, FI parameters are the best discriminants, with the cut-off values of 5.30, 2.30, 199, and 36.0, respectively.ConclusionsThe quantitative assessment of placental vasculature and placental volume by means of 3D Power Doppler and VOCAL technique is an adjunctive modality for differentiation between normal and IUGR pregnancies. Our findings further suggest that the vascularization index (VI) and vascularization flow index (VFI) are the best parameters with the most favorable discriminating potential for proper identification of IUGR pregnancies.

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Section: Discussionsupporting

confidence: 72%

Comparative analysis of placental vasculature and placental volume in normal and IUGR pregnancies with the use of three-dimensional Power Doppler

Pomorski

Zimmer

Florjański

et al. 2011

Arch Gynecol Obstet

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“…During the third trimester the vascular villous tree is fully developed and the third-order villous vessels can be rendered with a growing thickness and density of their branches [51] (Figure 26E and F). This pattern of vascular development is very similar to that described in the classical histological studies and even by electronic microscopy [53].…”

Section: Placental Circulationsupporting

confidence: 68%

“…Moreover, the decrease in the intraplacental blood flow may precede the umbilical resistance increase [56]. The blood flow through the intraplacental vascular tree could be affected in some cases with normal umbilical Doppler [53]. In fact, the intra-placental vascular resistance obtained by multigate spectral Doppler is more sensitive and its alteration precedes the umbilical Doppler changes to detect the fetal growth restriction [56].…”

Section: Placental Circulationmentioning

confidence: 97%

“…In fact, the intra-placental vascular resistance obtained by multigate spectral Doppler is more sensitive and its alteration precedes the umbilical Doppler changes to detect the fetal growth restriction [56]. It has also been proven that the number of villous arteries is significantly diminished in growth retarded gestations ( Figure 28) [53].…”

Section: Placental Circulationmentioning

confidence: 98%

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3D power Doppler in the study of fetal and maternal angiogenesis and vasculogenesis

Kurjak

Mercé

Andonotopo

2006

The Ultrasound Review of Obstetrics & Gynecology

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Using combined B-mode and power Doppler imaging, we were able to evaluate fetal growth and the development of fetal circulation. Fully digitalized 3D ultrasound devices with complete storage of data were used. Different rendering modes were utilized in color-coded data processing and presentation. A minimum-intensity mode was used to create a translucent image, while surface-rendered vascular images were shown in a maximum-intensity mode. The former was superior in assessment of spatial interrelationship of the vascular structures, and the latter was useful in the assessment of the morphology and outer surface of a confined vascular structure.

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“…The ability to monitor velocity in the intraplacental arteries is valuable because this site is closer to known sites of vascular pathology in human IUGR placentas (22) and because waveforms in intraplacental fetal arteries may be abnormal before waveforms in the umbilical artery are affected in human fetuses with IUGR (52). The number of detectable fetal intraplacental arteries in human fetuses with intrauterine growth retardation is also reduced (40). Thus, in mouse models of IUGR, we speculate that abnormalities may be more apparent in the intraplacental than umbilical arterial waveforms.…”

Section: Discussionmentioning

confidence: 96%

Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation

Adamson²

2006

American Journal of Physiology-Heart and Circulatory Physiology

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110

104

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In human pregnancy, abnormal placental hemodynamics likely contribute to the etiology of early-onset preeclampsia and fetal intrauterine growth restriction. The mouse is increasingly being deployed to study normal and abnormal mammalian placental development, yet the placental hemodynamics in normal pregnancy in mice is currently unknown. We used ultrasound biomicroscopy to noninvasively image and record Doppler blood velocity waveforms from the maternal and embryonic placental circulations in mice throughout gestation. In the uterine artery, peak systolic velocity (PSV) increased significantly from 23 ± 2 (SE) to 59 ± 3 cm/s, and end-diastolic velocity (EDV) increased from 7 ± 1 to 28 ± 2 cm/s in nonpregnant versus full-term females so that the uterine arterial resistance index (RI) decreased from 0.70 ± 0.02 to 0.53 ± 0.02. Velocities in the maternal arterial canal in the placenta were low and nearly steady and increased from 0.9 ± 0.03 cm/s at embryonic day 10.5 (E10.5) to 2.4 ± 0.07 cm/s at E18.5. PSV in the umbilical artery increased steadily from 0.8 ± 0.1 cm/s at E8.5 to 15 ± 0.6 cm/s at E18.5, whereas PSV in the vitelline artery increased from 0.6 ± 0.1 cm/s at E8.5 to 4 ± 0.2 cm/s at E13.5 and then remained stable to term. In the umbilical artery, the EDV detection rate was 0% at ≤E14.5 and 94% at E18.5, and the RI decreased from 1 to 0.82 ± 0.01 during this interval. We conclude that ultrasound biomicroscopy can be used to monitor placental hemodynamics during pregnancy in mice. These results provide novel information concerning the development of the vitelline and placental circulations in mice and reveal strong similarities in placental hemodynamics between mice and humans.

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Investigation of intraplacental villous arteries by doppler flow imaging in growth-restricted fetuses

Cited by 18 publications

References 19 publications

Comparative analysis of placental vasculature and placental volume in normal and IUGR pregnancies with the use of three-dimensional Power Doppler

Comparative analysis of placental vasculature and placental volume in normal and IUGR pregnancies with the use of three-dimensional Power Doppler

3D power Doppler in the study of fetal and maternal angiogenesis and vasculogenesis

Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation

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